Emine Gülçeri GÜLEÇ PEKER
(Giresun Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü, Giresun, Türkiye)
Doç. Dr. Barbaros BALABANLI
(Gazi Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)
Çiğdem ÖZER
(Gazi Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Ankara, Türkiye)
Şule COŞKUN CEVHER
(Gazi Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Ankara, Türkiye)
Yıl: 2021Cilt: 6Sayı: 3ISSN: 2548-0006Sayfa Aralığı: 357 - 363İngilizce

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Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes
Benfluorex is a pharmacological agent with antidiabetic and antihyperlipidemic properties. In this study, the brain's oxidative and non-enzymatic antioxidant status in diabetic and benfluorex administrated diabetic rats have been investigated. For the experimental procedures, three groups of 18 Wistar albino rats were used as the control, diabetes (induced by streptozotocin), and benfluorex treated diabetic rats (benfluorex administration intragastric 50 mg/kg daily for 21 days). Brain NOx, TBARS, GSH, AA levels, and MPO activity were determined spectrophotometrically. Benfluorex administration was caused that decreased lipid peroxidation and MPO activity while increased non-enzymatic antioxidant and NOx levels. These results showed that benfluorex treatment positively affects lipid peroxidation and non-enzymatic antioxidant status of the brain during diabetes.
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