Yıl: 2021 Cilt: 6 Sayı: 3 Sayfa Aralığı: 357 - 363 Metin Dili: İngilizce DOI: 10.35229/jaes.929547 İndeks Tarihi: 29-07-2022

Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes

Öz:
Benfluorex is a pharmacological agent with antidiabetic and antihyperlipidemic properties. In this study, the brain's oxidative and non-enzymatic antioxidant status in diabetic and benfluorex administrated diabetic rats have been investigated. For the experimental procedures, three groups of 18 Wistar albino rats were used as the control, diabetes (induced by streptozotocin), and benfluorex treated diabetic rats (benfluorex administration intragastric 50 mg/kg daily for 21 days). Brain NOx, TBARS, GSH, AA levels, and MPO activity were determined spectrophotometrically. Benfluorex administration was caused that decreased lipid peroxidation and MPO activity while increased non-enzymatic antioxidant and NOx levels. These results showed that benfluorex treatment positively affects lipid peroxidation and non-enzymatic antioxidant status of the brain during diabetes.
Anahtar Kelime: diabetes non-enzymatic antioxidants Benfluorex brain lipid peroxidation

Benfloreks: Dost mu, Düşman mı? Deneysel Diyabette, Benfloreksin Beyindeki Oksidatif Olaylara Etkileri

Öz:
Benfloreks, antidiyabetik ve antihiperlipidemik özelliklere sahip farmakolojik bir ajandır. Bu çalışmada, uygulanan diyabetik sıçanlarda benfloreks tedavisinin beynin oksidatif ve enzimatik olmayan antioksidan durumu üzerindeki etkileri araştırılmıştır. Deneysel prosedürler için, kontrol, diyabet (streptozotosin ile indüklenen) ve benfloreks ile tedavi edilmiş diyabetik sıçanlar (benfloreks 21 gün boyunca intragastrik 50 mg/kg dozda uygulanmıştır) olarak 18 Wistar albino sıçanından oluşan üç grup kullanıldı. Beyin NOx, TBARS, GSH, AA seviyeleri ve MPO aktivitesi spektrofotometrik olarak belirlendi. Benfloreks uygulaması, lipid peroksidasyonunu ve MPO aktivitesini azaltırken; enzimatik olmayan antioksidan seviyelerini ve NOx düzeylerini arttırmıştır. Bu sonuçlar, benfloreks tedavisinin, diyabet sırasında beynin lipid peroksidasyonunu ve enzimatik olmayan antioksidan durumu olumlu etkilediğini göstermiştir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÜLEÇ PEKER E, BALABANLI B, özer ç, COŞKUN CEVHER Ş (2021). Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. , 357 - 363. 10.35229/jaes.929547
Chicago GÜLEÇ PEKER Emine Gülçeri,BALABANLI BARBAROS,özer çiğdem,COŞKUN CEVHER ŞULE Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. (2021): 357 - 363. 10.35229/jaes.929547
MLA GÜLEÇ PEKER Emine Gülçeri,BALABANLI BARBAROS,özer çiğdem,COŞKUN CEVHER ŞULE Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. , 2021, ss.357 - 363. 10.35229/jaes.929547
AMA GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. . 2021; 357 - 363. 10.35229/jaes.929547
Vancouver GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. . 2021; 357 - 363. 10.35229/jaes.929547
IEEE GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş "Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes." , ss.357 - 363, 2021. 10.35229/jaes.929547
ISNAD GÜLEÇ PEKER, Emine Gülçeri vd. "Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes". (2021), 357-363. https://doi.org/10.35229/jaes.929547
APA GÜLEÇ PEKER E, BALABANLI B, özer ç, COŞKUN CEVHER Ş (2021). Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 6(3), 357 - 363. 10.35229/jaes.929547
Chicago GÜLEÇ PEKER Emine Gülçeri,BALABANLI BARBAROS,özer çiğdem,COŞKUN CEVHER ŞULE Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 6, no.3 (2021): 357 - 363. 10.35229/jaes.929547
MLA GÜLEÇ PEKER Emine Gülçeri,BALABANLI BARBAROS,özer çiğdem,COŞKUN CEVHER ŞULE Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, vol.6, no.3, 2021, ss.357 - 363. 10.35229/jaes.929547
AMA GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2021; 6(3): 357 - 363. 10.35229/jaes.929547
Vancouver GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes. JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES. 2021; 6(3): 357 - 363. 10.35229/jaes.929547
IEEE GÜLEÇ PEKER E,BALABANLI B,özer ç,COŞKUN CEVHER Ş "Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes." JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, 6, ss.357 - 363, 2021. 10.35229/jaes.929547
ISNAD GÜLEÇ PEKER, Emine Gülçeri vd. "Benfluorex, Friends or Foe? The Effects of Benfluorex on Oxidative Status in the Brain During Experimental Diabetes". JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES 6/3 (2021), 357-363. https://doi.org/10.35229/jaes.929547