Yıl: 2021 Cilt: 49 Sayı: 1 Sayfa Aralığı: 25 - 29 Metin Dili: İngilizce DOI: 10.5152/TJAR.2020.484 İndeks Tarihi: 11-10-2021

Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients

Öz:
Objective: In anemic patients undergoing surgery, there is an increase in the requirement of blood transfusion, longer hospital stay and higher intensive care unit adimission. In this study we aimed to evaluate the efficacy of iv iron treatment before elective obstetric or gynecological operations retrospectively.Methods: After obtaining approval of ethics committee, records of 5688 patients underwent either obstetric or gynecological surgery between January 1st of 2016 to December 31st of 2018 were documented retrospectively and 241 anemic cases were identified. Eighty-one anemic patients who did not receive any iv iron treatment preoperatively were excluded and 160 cases treated with either iv iron (either sucrose or ferric carboxy maltose) were included. The laboratory results including haemoglobin (Hb), MCV,MCH and serum iron binding capacities, ferritin, iron and transferrin levels were documented before (preoperative) and after iv iron treatment (postoperative 10th day) were collected from files. Difference between preoperative and postoperative Hb, MCV, MCH, TIBC, serum ferritin, iron and transferrin levels of these cases were determined.Results: In 97 obstetric cases, the differences of Hb, MCV, MCH, serum iron, ferritin, iron binding capacity values before surgery and postoperative 10th day were respectively found as 1.3 g dL-1 (p=0.000); 1.9 fL (p=0.000); 0.3 pg (p=0.01); 44.4 μg dL-1 (p=0.008); 85.9 μg L-1 (p=0.009); 211.7 μg dL-1 (p=0.001). In 63 gynecologic cases, same measurements were evaluated and similar differences in Hb, MCV, MCH, serum ferritin and transferrin saturation values were 1.25 g dL-1 (p=0.000); 2.2 fL (p=0.000); 0.8 pg (p=0.000); 215.6 μg L-1 (p=0.002); 41.5% (p=0.044). Two obstetric patients and 7 gynaecologic patients were transfused erytrocyte suspensions after surgery.Conclusion: Efficacy of preoperative iv iron therapy in gynaecologic-obstetric patients with IDA has been demonstrated and its importance has been revisited once again.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. The Global Prevalence of Anaemia in 2011. Available from: https://apps.who.int/iris/bitstream/handle/10665/177094/9789241564960_eng.pdf?sequence=1.
  • 2. Roy, NB, Pavord, S. The management of anaemia and haematinic deficiencies in pregnancy and post‐partum. Transfusion Med 2018; 28: 107-16. [Crossref]
  • 3. Tunkyi K, Moodley J Anemia and pregnancy outcomes: A longitidunal study. J Maternal Fetal Neonatal Med 2018; 31: 2594-8. [Crossref]
  • 4. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol 2015; 52: 339-47. [Crossref]
  • 5. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263-8. [Crossref]
  • 6. Spahn DR, Goodnough LT. Alternatives to blood transfusion. Lancet 2013; 381: 1855-65. [Crossref]
  • 7. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, Aldecoa C, Barauskas G, et al. Management of severe perioperative bleeding guidelines from the European Society of Anaesthesiology First update 2016. Eur J Anaesthesiol 2017; 34: 332-95. [Crossref]
  • 8. Muñoz M, Peña-Rosas JP, Robinson S, Milman N, Holzgreve W, Breymann C, et al. Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Transfus Med 2018; 28: 22-39. [Crossref]
  • 9. Richards T, Musallam KM, Nassif J, Ghazeeri G, Seoud M, Gurusamy KS, et al. Impact of Preoperative Anaemia and Blood Transfusion on Postoperative Outcomes in Gynaecological Surgery. PLoS One 2015; 10: e0130861. [Crossref]
  • 10. Breymann C, Milman N, Mezzacasa A, Bernard R, Dudenhausen J; FER-ASAP investigators. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med 2017; 45: 443-53. [Crossref]
  • 11. Govindappagari S, Burwick RM. Treatment of iron deficiency anemia in pregnancy with intravenous versus oral iron: systematic review and meta-analysis. Am J Perinatol 2019; 36: 366-76. [Crossref]
  • 12. Lewkowitz AK, Gupta A, Simon L, Sabol BA, Stoll C, Cooke E, et al. Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis. J Perinatol 2019; 39: 519-32. [Crossref]
  • 13. Ellermann I, Bueckmann A, Eveslage M, Buddendick H, Latal T, Niehoff D, et al. Treating Anemia in the Preanesthesia Assessment Clinic: Results of a Retrospective Evaluation. Anesth Analg 2018; 127: 1202-10. [Crossref]
  • 14. De Hert S, Staender S, Fritsch G, Hinkelbein J, Afshari A, Bettelli G, et al. Preoperative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology. Eur J Anaesthesiol 2018; 35: 407-65. [Crossref]
  • 15. Holm C, Thomsen LL, Norgaard A, Langhoff-Roos J. Single-dose intravenous iron infusion or oral iron for treatment of fatigue after postpartum haemorrhage: a randomized controlled trial. Vox Sang 2017; 112: 219-28. [Crossref]
  • 16. Van Wyck DB, Mangione A, Morrison J, Hadley PE, Jehle JA, Goodnough LT. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial. Transfusion 2009; 49: 2719-28. [Crossref]
APA GÜNAYDIN D, Isik G, Bagcaz S, İnan G, Bozkurt N, OZKURT Z, Onan M (2021). Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. , 25 - 29. 10.5152/TJAR.2020.484
Chicago GÜNAYDIN DUDU BERRİN,Isik Gizem,Bagcaz Selin,İnan Gozde,Bozkurt Nuray,OZKURT ZÜBEYDE NUR,Onan MEHMET ANIL Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. (2021): 25 - 29. 10.5152/TJAR.2020.484
MLA GÜNAYDIN DUDU BERRİN,Isik Gizem,Bagcaz Selin,İnan Gozde,Bozkurt Nuray,OZKURT ZÜBEYDE NUR,Onan MEHMET ANIL Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. , 2021, ss.25 - 29. 10.5152/TJAR.2020.484
AMA GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. . 2021; 25 - 29. 10.5152/TJAR.2020.484
Vancouver GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. . 2021; 25 - 29. 10.5152/TJAR.2020.484
IEEE GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M "Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients." , ss.25 - 29, 2021. 10.5152/TJAR.2020.484
ISNAD GÜNAYDIN, DUDU BERRİN vd. "Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients". (2021), 25-29. https://doi.org/10.5152/TJAR.2020.484
APA GÜNAYDIN D, Isik G, Bagcaz S, İnan G, Bozkurt N, OZKURT Z, Onan M (2021). Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. Turkish Journal of Anaesthesiology and Reanimation, 49(1), 25 - 29. 10.5152/TJAR.2020.484
Chicago GÜNAYDIN DUDU BERRİN,Isik Gizem,Bagcaz Selin,İnan Gozde,Bozkurt Nuray,OZKURT ZÜBEYDE NUR,Onan MEHMET ANIL Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. Turkish Journal of Anaesthesiology and Reanimation 49, no.1 (2021): 25 - 29. 10.5152/TJAR.2020.484
MLA GÜNAYDIN DUDU BERRİN,Isik Gizem,Bagcaz Selin,İnan Gozde,Bozkurt Nuray,OZKURT ZÜBEYDE NUR,Onan MEHMET ANIL Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. Turkish Journal of Anaesthesiology and Reanimation, vol.49, no.1, 2021, ss.25 - 29. 10.5152/TJAR.2020.484
AMA GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. Turkish Journal of Anaesthesiology and Reanimation. 2021; 49(1): 25 - 29. 10.5152/TJAR.2020.484
Vancouver GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients. Turkish Journal of Anaesthesiology and Reanimation. 2021; 49(1): 25 - 29. 10.5152/TJAR.2020.484
IEEE GÜNAYDIN D,Isik G,Bagcaz S,İnan G,Bozkurt N,OZKURT Z,Onan M "Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients." Turkish Journal of Anaesthesiology and Reanimation, 49, ss.25 - 29, 2021. 10.5152/TJAR.2020.484
ISNAD GÜNAYDIN, DUDU BERRİN vd. "Retrospective Evaluation of Effects of Preoperative Anaemia Treatment in Gynaecological and Obstetric Surgical Patients". Turkish Journal of Anaesthesiology and Reanimation 49/1 (2021), 25-29. https://doi.org/10.5152/TJAR.2020.484