Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections

Yıl: 2020 Cilt: 31 Sayı: 12 Sayfa Aralığı: 894 - 901 Metin Dili: İngilizce DOI: 10.5152/tjg.2020.19286 İndeks Tarihi: 20-10-2021

Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections

Öz:
Background/Aims: Despite surgical advances in liver transplantation and effective prophylactic strategies, posttransplant infections are the most important cause of morbidity and mortality. Diagnosis and management of infections because of developing immunosuppression is difficult and adversely affects mortality. This study aimed to review bacterial and fungal infections in patients after liver transplantation and to reveal the resistance rates.Materials and Methods: A total of 107 patients who underwent liver transplantation between January 2017 and February 2018 were evaluated retrospectively with regard to demographic characteristics, causes of transplantation, conditions that may lead to infection, postoperative infections, pathogens, and resistance patterns.Results: Of the 107 patients who underwent liver transplantation, 48 (44.8%) had an infection. Bacterial infections were detected in 41% of the patients, and fungal infections were found in 13%. When we compared living and cadaveric transplants in terms of infection development, these rates were found to be 53% and 33%, respectively (p=0.034). No statistically significant results could be obtained when evaluating conditions such as sex, presence of underlying primary disease, Model for End-Stage Liver Disease MELD score, diabetes status, total parenteral nutrition, and risk factors for infection.Conclusion: After liver transplantation, infections are often seen in the first month of the postoperative period. Knowing the most common pathogens and resistance states in this process reduces infection-related deaths by providing appropriate treatment regimens at the right time.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Arslan H. Karaciğer transplantasyonu sonrası infeksiyonlarda risk ve epidemiyoloji, In: Köse Ş, Yalçın AN, Erbay RH eds. Transplant İn feksiyonları. Section 16 p.203-10.
  • 2. Bayar F, Bayındır Y, Işık B, Özgör D, Kayabaş Ü, Kuzucu Ç, Yılmaz S. Evaluation of Nosocomial Infections after ABO-Compatible and Incompatible Liver Transplantations. Mediterr J Infect Microb Anti microb 2018; 7 :14
  • 3. Torbenson M, Wang J, Nichols L, Jain A, Fung J, Nalesnik MA. Caus es of death in autopsied liver transplantation patients. Mod Pathol 1998; 11: 37.
  • 4. Türk Toraks Derneği Erişkinlerde Hastanede Gelişen Pnömoni Tanı ve Tedavi Uzlaşı Raporu (2018). Available on: https://www.toraks. org.tr/uploadFiles/book/file/223201815353-TTJHGPUzlasiRapo ru21MART2018.pdf
  • 5. Centers for Disease Control and Prevention. Guideline for Preven tion of Catheter-Associated Urinary Tract Infections (2009) https:// www.cdc.gov/infectioncontrol/guidelines/cauti/
  • 6. Centers for Disease Control and Prevention. Guidelines for the Prevention of Intravascular Catheter-Related Infections (2011) https://www.cdc.gov/infectioncontrol/guidelines/bsi/recommenda tions.html
  • 7. Avkan-Oğuz V, Baykam N, Sökmen S, et al. Recommendations for intra-abdominal infections consensus report. Ulus Cerrahi Derg 2016; 32: 306-21.
  • 8. National Nosocomial Infections Surveillance System. Nation al Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32: 470-85.
  • 9. Zeytunlu M, Uğuz A, Ünalp Ö, et al. Results of 1001 liver transplan tations in 23 years: Ege University experience. Turk J Gastroenterol 2018; 29: 664-8.
  • 10. Yamashiki N, Sugawara Y, Tamura S, et al. Outcomes after living donor liver transplantation for acute liver failure in Japan: results of a nationwide survey. Liver Transpl 2012; 18: 1069-77.
  • 11. Tacke F, Kroy DC, Barreiros AP, Neumann UP. Liver transplanta tion in Germany. Liver Transpl 2016; 22: 1136-42.
  • 12. Neuberger J. Liver transplantation in the United Kingdom. Liver Transpl 2016; 22: 1129-35.
  • 13. Roberts MS, Angus DC, Bryce CL, Valenta Z, Weissfeld L. Survival after liver transplantation in the United States: a disease-specif ic analysis of the UNOS database. Liver Transpl 2004; 10: 886-97.
  • 14. Kim SI. Bacterial infection after liver transplantation. World J Gastroenterol 2014; 20: 6211-20.
  • 15. Kim YJ, Kim SI, Wie SH, et al. Infectious complications in liv ing-donor liver transplant recipients: a 9-year single-center experi ence. Transpl Infect Dis 2008; 10: 316-24.
  • 16. Li C, Wen TF, Mi K, Wang C, Yan LN, Li B. Analysis of infections in the first 3 month after living donor liver transplantation. World J Gastroenterol 2012; 18: 1975-80.
  • 17. Ki HK, Son JS, Oh WS, et al. Infectious Complications after Liver Transplantation according to Donor: Comparison between Orthot opic and Living Donor Transplantation. Infect Chemother 2004; 36: 139-47.
  • 18. Avkan-Oguz V, Ozkardesler S, Unek T, et al. Risk Factors for Early Bacterial Infections in Liver Transplantation Transplant Proc 2013; 45: 993-7.
  • 19. Fishman JA. Infection in solid-organ transplant recipients. Am J Transplant 2017; 17: 856-79.
  • 20. Martin P, DiMartini A, Feng S, Brown R Jr, Fallon M. Evalua tion for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology 2014; 59: 1144- 65.
  • 21. Saner FH, Olde Damink SWM, Pavlakovic G, et al. Pulmonary and blood stream infections in adult living donor and cadaveric liver transplant patients. Transplantation 2008; 85: 1564-8.
  • 22. Singh N, Wagener MM, Obman A, Cacciarelli TV, de Vera ME, Gayowski T. Bacteremias in liver transplant recipients: shift toward gram-negative bacteria as predominant pathogens. Liver Transpl 2004; 10: 844-9.
  • 23. Sganga G, Spanu T, Bianco G, et al. Bacterial bloodstream in fections in liver transplantation: etiologic agents and antimicrobial susceptibility profiles. Transplant Proc 2012; 44: 1973-6.
  • 24. Erdem HA, Sipahi OR, Kepeli N, et al. Point Prevalence of Hospi tal-Acquired Infections in Ege University Hospital. Mediterr J Infect Microb Antimicrob 2015; 4: 12
  • 25. Liu X, Ling Z, Li L, Ruan B. Invasive fungal infections in liver trans plantation. Int J Infect Dis 2011; 15: e298-304.
  • 26. Netsvyetayeva I, Swoboda-Kopeć E, Paczek L, et al. Trichosporon asahii as a prospective pathogen in solid organ transplant recipi ents. Mycoses 2009; 52: 263-5.
  • 27. Abdala E, Lopes RI, Chaves CN, Heins-Vaccari EM, Shikanai-Ya suda MA. Trichosporon asahii fatal infection in a non-neutropenic patient after orthotopic liver transplantation. Transpl Infect Dis 2005; 7: 162-5.
  • 28. Biasoli MS, Carlson D, Chiganer GJ, et al. Systemic infection caused by Trichosporon asahii in a patient with liver transplant. Med Mycol 2008; 46: 719-23.
APA Yamazhan T, bulut avsar c, Zeytunlu M, Tasbakan m, Sertöz R, ZEYTINOGLU A, Aydemir S, unalp o, Ergun O, uguz a, EROL f, gunsar f, TURAN I, Ulukaya S, Deniz M, Yılmaz F, Nart D, Guler E, turhan k, karasu z (2020). Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. , 894 - 901. 10.5152/tjg.2020.19286
Chicago Yamazhan Tansu,bulut avsar cansu,Zeytunlu Murat,Tasbakan meltem,Sertöz Rüçhan,ZEYTINOGLU AYSIN,Aydemir Sabire Şöhret,unalp omer,Ergun Orkan,uguz alper,EROL funda,gunsar fulya,TURAN ILKER,Ulukaya Sezgin,Deniz Mustafa Nuri,Yılmaz Funda,Nart Deniz,Guler Ezgi,turhan kutsal,karasu zeki Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. (2020): 894 - 901. 10.5152/tjg.2020.19286
MLA Yamazhan Tansu,bulut avsar cansu,Zeytunlu Murat,Tasbakan meltem,Sertöz Rüçhan,ZEYTINOGLU AYSIN,Aydemir Sabire Şöhret,unalp omer,Ergun Orkan,uguz alper,EROL funda,gunsar fulya,TURAN ILKER,Ulukaya Sezgin,Deniz Mustafa Nuri,Yılmaz Funda,Nart Deniz,Guler Ezgi,turhan kutsal,karasu zeki Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. , 2020, ss.894 - 901. 10.5152/tjg.2020.19286
AMA Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. . 2020; 894 - 901. 10.5152/tjg.2020.19286
Vancouver Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. . 2020; 894 - 901. 10.5152/tjg.2020.19286
IEEE Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z "Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections." , ss.894 - 901, 2020. 10.5152/tjg.2020.19286
ISNAD Yamazhan, Tansu vd. "Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections". (2020), 894-901. https://doi.org/10.5152/tjg.2020.19286
APA Yamazhan T, bulut avsar c, Zeytunlu M, Tasbakan m, Sertöz R, ZEYTINOGLU A, Aydemir S, unalp o, Ergun O, uguz a, EROL f, gunsar f, TURAN I, Ulukaya S, Deniz M, Yılmaz F, Nart D, Guler E, turhan k, karasu z (2020). Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. Turkish Journal of Gastroenterology, 31(12), 894 - 901. 10.5152/tjg.2020.19286
Chicago Yamazhan Tansu,bulut avsar cansu,Zeytunlu Murat,Tasbakan meltem,Sertöz Rüçhan,ZEYTINOGLU AYSIN,Aydemir Sabire Şöhret,unalp omer,Ergun Orkan,uguz alper,EROL funda,gunsar fulya,TURAN ILKER,Ulukaya Sezgin,Deniz Mustafa Nuri,Yılmaz Funda,Nart Deniz,Guler Ezgi,turhan kutsal,karasu zeki Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. Turkish Journal of Gastroenterology 31, no.12 (2020): 894 - 901. 10.5152/tjg.2020.19286
MLA Yamazhan Tansu,bulut avsar cansu,Zeytunlu Murat,Tasbakan meltem,Sertöz Rüçhan,ZEYTINOGLU AYSIN,Aydemir Sabire Şöhret,unalp omer,Ergun Orkan,uguz alper,EROL funda,gunsar fulya,TURAN ILKER,Ulukaya Sezgin,Deniz Mustafa Nuri,Yılmaz Funda,Nart Deniz,Guler Ezgi,turhan kutsal,karasu zeki Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. Turkish Journal of Gastroenterology, vol.31, no.12, 2020, ss.894 - 901. 10.5152/tjg.2020.19286
AMA Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. Turkish Journal of Gastroenterology. 2020; 31(12): 894 - 901. 10.5152/tjg.2020.19286
Vancouver Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections. Turkish Journal of Gastroenterology. 2020; 31(12): 894 - 901. 10.5152/tjg.2020.19286
IEEE Yamazhan T,bulut avsar c,Zeytunlu M,Tasbakan m,Sertöz R,ZEYTINOGLU A,Aydemir S,unalp o,Ergun O,uguz a,EROL f,gunsar f,TURAN I,Ulukaya S,Deniz M,Yılmaz F,Nart D,Guler E,turhan k,karasu z "Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections." Turkish Journal of Gastroenterology, 31, ss.894 - 901, 2020. 10.5152/tjg.2020.19286
ISNAD Yamazhan, Tansu vd. "Infections developing in patients undergoing livertransplantation: Recipients of living donors may be moreprone to bacterial/fungal infections". Turkish Journal of Gastroenterology 31/12 (2020), 894-901. https://doi.org/10.5152/tjg.2020.19286