Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women

Turan, Gökçe; kul, gülnur

doi:10.17826/cumj.903637

Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women

Gülnur KUL, (Kırıkhan Devlet Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Hatay, Türkiye)

Gökçe TURAN (Gazi Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

Cukurova Medical Journal

5 0

Yıl: 2021 Cilt: 46 Sayı: 3 Sayfa Aralığı: 975 - 981 Metin Dili: İngilizce DOI: 10.17826/cumj.903637 İndeks Tarihi: 29-07-2022

Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women

Öz:

Purpose: Toxoplasma gondii, rubella and cytomegalovirus (TORCH) infections are the leading causes of perinatal morbidity and mortality, especially in developing countries. This study aimed to compare the seroprevalence of Toxoplasma and Rubella in Turkish pregnant women and Syrian refugee pregnant women, whose number is increasing in our region. Materials and Methods: Syrian and Turkish pregnant women between the ages of 18 and 49 who were admitted to a secondary care hospital for their first prenatal visit between March 2018 and November 2019 were included in this retrospective study. Age, gravida, parity, nationality and anti-T. gondii IgM, anti-T. gondii IgG, anti-Rubella IgM, and anti-Rubella IgG test results of the patients included in the study were retrospectively recorded from the hospital archive and compared. Results: Out of 3,606 pregnant women included in the study, 2,768 (76.7%) were Turkish and 838 (23.3%) were Syrian. Anti-T. gondii IgM positivity rate (6.1%) of Syrian pregnant women was significantly higher than the rate (2.1%) of Turkish pregnant women. Although AntiRubella IgG positivity was not statistically significantly different it was higher in Turkish pregnant women (85.2% and 88.7% respectively). Conclusion: Knowing the incidence and prevalence of toxoplasma and rubella infection in pregnant women plays a critical role in determining the burden of the disease, planning screening programs, and active use of primary healthcare services. Screening programs in antenatal care for toxoplasma and rubella should especially be planned in regions that provide healthcare by considering the increasing number of Syrian refugees.

Anahtar Kelime: rubella Syrian refugees pregnancy seroprevalence toxoplasma gondii

Suriyeli ve Türk gebelerin Toksoplazma ve Rubella seropozitifliğinin karşılaştırılması

Öz:

Amaç: Toxoplasma gondii, rubella ve sitomegalovirüs (TORCH) enfeksiyonları, özellikle gelişmekte olan ülkelerde perinatal morbidite ve mortalitenin önde gelen nedenleridir. Bu çalışmada bölgemizde artan Suriyeli mülteci gebeler ile Türk gebelerdeki Toxoplasma ve Rubella seroprevelansının karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamıza Mart 2018-Kasım 2019 tarihleri arasında hastanemize ilk prenatal vizitte başvuran 18-49 yaş arası Suriyeli ve Türk gebeler dahil edildi. Dahil edilen hastaların yaş, gravida, parite, uyruğu ve ilk trimesterdaki anti- T. gondii IgM, anti- T. gondii IgG, antiRubella IgM, anti-Rubella IgG sonuçları hastane arşivinden retrospektif olarak kaydedildi ve karşılaştırıldı. Bulgular: Çalışmaya katılan 3606 gebenin 2768’i (%76,7) Türk, 838’si (%23,3) ise Suriyeli idi. Suriyeli gebelerin anti T. gondii IgM pozitifliği (%6,1), Türk gebelere göre (%2,1) anlamlı olarak daha yüksek bulundu. Anti Rubella IgM pozitifliği her iki grupta benzerdi. Anti rubella IgG ise istatistiksel olarak anlamlı olmamakla birlikte Türk gebelerde daha yüksekti (sırasıyla %85,2 ve %88,7). Sonuç: Gebe kadınlarda toksoplazma ve rubella enfeksiyonu sıklığı ve yaygınlığı hakkında bilgi sahibi olmak, hastalık yükünün belirlenmesinde, tarama programlarının planlanmasında ve birinci basamak sağlık hizmetlerinin aktif kullanımında kritik bir rol oynamaktadır. Toksoplazma ve rubella gibi doğum öncesi bakımda tarama programları, Suriyeli mülteci sayısının artması dikkate alınarak sağlık hizmeti veren bölgelere özel olarak planlanmalıdır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Bahat PY, Turan G, Özgör BY, Çakmak KB. Comparison of hepatitis B, hepatitis C, and HIV seropositivity of Syrian and Turkish pregnant women. Turk J Obstet Gynecol. 2019;16:95.
2. Doğan K, Kafkaslı A, Karaman Ü, Atambay M, Karaoğlu L, Çolak C. Gebelerde Toksoplazma enfeksiyonunun seropozitiflik ve serokonversiyon oranları. Mikrobiyol Bul. 2012;46:290-4.
3. Topçu AW SG, Doğanay M. Toxoplasma gondii. İnfeksiyon Hastalıkları ve Mikrobiyolojisi. 1883– 97.İstanbul: Nobel Tıp Kitabevleri: Vol 2015.
4. Montoya JG KJ, Remington JS. Toxoplasma gondii. Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 6th ed. 3170–98: Philadelphia: Elsevier Churchill Livingstone Vol 2005.
5. Meek B, van Gool T, Gilis H, Peek R. Dissecting the IgM antibody response during the acute and latent phase of toxoplasmosis. Diagn Microbiol Infect Dis. 2001;41:131-7.
6. Varlı C, Türköz İ, Aydemir S, Emre S, Şimşek F, Yıldırmak M. Toksoplazmoz. Okmeydanı Tıp Dergisi. 2016;32:24-8.
7. Akpinar O, Akpinar H. Gebe kadinlarda rubella ve sitomegalovirus seroprevelansinin elisa yöntemi ile araştirilmasi. Balıkesir Sağlık Bilimleri Dergisi. 2017;6:11-5.
8. Aynioglu A, Aynioglu O, Altunok ES. Seroprevalence of Toxoplasma gondii, rubella and Cytomegalovirus among pregnant females in north-western Turkey. Acta Clin Belg. 2015;70:321-4.
9. Çetinkaya RA, Yenilmez E. The seroprevalence of Rubella in pregnant women in Turkey: a meta-analysis research of 90988 Rubella IgM, 84398 Rubella IgG, and 522 avidity results. Turk J Obstet Gynecol. 2019;16:63.
10. Çiçek AÇ, Duygu F, İnakçı İH, Boyar N, Boyar İH. Şanlıurfa ilinde doğurganlık çağındaki kadınlarda ELISA ile Toxoplasma gondii antikorlarının araştırılması: Üç yıllık değerlendirme. Journal of Clinical and Experimental Investigations. 2012;3:1-5.
11. Hamdan HZ, Abdelbagi IE, Nasser NM, Adam I. Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan. Virol J. 2011;8:217.
12. Bakacak M, Serin S, Aral M, Ercan Ö, Köstü B, Kireçci A, Bostancı MS, Bakacak Z. Kahramanmaraş yöresindeki yerleşik türk gebelerle suriyeli mülteci gebeler arasında toxoplasma seroprevalans farklılıkları. Turkiye Parazitol Derg. 2015;39:94-7.
13. Çoşkun B, Gülümser Ç, Çoşkun B, Artuk C, Karaşahin KE. Impact of Syrian refugees on congenital TORCH infections screening in Turkey. J Obstet Gynaecol Res. 2020; doi: 10.1111/jog.14273.
14. https://gocvakfi.org/tr/2019/11/20/2020-yilicumhurbaskanligi-yillik-programi-aciklandi/. Last accessed date: 20.05.2020
15. Cherri Z, Gil Cuesta J, Rodriguez-Llanes JM, GuhaSapir D. Early marriage and barriers to contraception among Syrian refugee women in Lebanon: a qualitative study. Int J Environ Res Public Health. 2017;14:836.
16. Puccio G, Cajozzo C, Canduscio LA, Cino L, Romano A, Schimmenti MG et al. Epidemiology of Toxoplasma and CMV serology and of GBS colonization in pregnancy and neonatal outcome in a Sicilian population. Ital J Pediatr. 2014;40:23.
17. Wong A, Tan K, Tee C, Yeo G. Seroprevalence of cytomegalovirus, toxoplasma and parvovirus in pregnancy. Singapore Med J. 2000;41:151-5.
18. de Melo Inagaki AD, de Oliveira LAR, de Oliveira MFB, Santos RCS, Araújo RM, Alves JAB et al. Seroprevalence of antibodies for toxoplasmosis, rubella, cytomegalovirus, syphilis and HIV among pregnant women in Sergipe. Rev Soc Bras Med Trop. 2009;42.
19. Pradhan S. Epidemiological and serological profiles of TORCH infection in pregnancy. Journal of Pathology of Nepal. 2015;5:705-8.
20. Sen M, Shukla B, Tuhina B. Prevalence of serum antibodies to TORCH infection in and around Varanasi, Northern India. J Clin Diagn Res JCDR. 2012;6:1483.
21. Bakacak M, Bostancı MS, Köstü B, Ercan Ö, Serin S, Avcı F. Gebelerde Toxoplasma gondii, rubella ve sitomegalovirüs seroprevalansı. Dicle Tıp Dergisi. 2014;41:326-31.
22. Harma M, Gungen N, Demir N. Toxoplasmosis in pregnant women in Sanliurfa, Southeastern Anatolia City, Turkey. J Egypt Soc Parasitol. 2004;34:519-25.
23. Gioula G, Exindari M, Melidou A, Minti F, Sidiropoulou E, Dionisopoulou S et al. Seroprevalence of measles in Northern Greece. Acta Microbiologica Hellenica. 2017;62:145-50.
24. Mongua-Rodriguez N, Díaz-Ortega JL, García-García L, Piña-Pozas M, Ferreira-Guerrero E, DelgadoSánchez G et al R. A systematic review of rubella vaccination strategies implemented in the Americas: impact on the incidence and seroprevalence rates of rubella and congenital rubella syndrome. Vaccine. 2013;31:2145-51.
25. Thayyil J, Kuniyil V, Moorkoth AP, Rao B, Selvam P. Prevalence of rubella-specific IgG antibodies in unimmunized young female population. J Family Med Prim Care. 2016;5:658.

APA	kul g, Turan G (2021). Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. , 975 - 981. 10.17826/cumj.903637
Chicago	kul gülnur,Turan Gökçe Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. (2021): 975 - 981. 10.17826/cumj.903637
MLA	kul gülnur,Turan Gökçe Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. , 2021, ss.975 - 981. 10.17826/cumj.903637
AMA	kul g,Turan G Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. . 2021; 975 - 981. 10.17826/cumj.903637
Vancouver	kul g,Turan G Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. . 2021; 975 - 981. 10.17826/cumj.903637
IEEE	kul g,Turan G "Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women." , ss.975 - 981, 2021. 10.17826/cumj.903637
ISNAD	kul, gülnur - Turan, Gökçe. "Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women". (2021), 975-981. https://doi.org/10.17826/cumj.903637

APA	kul g, Turan G (2021). Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. Cukurova Medical Journal, 46(3), 975 - 981. 10.17826/cumj.903637
Chicago	kul gülnur,Turan Gökçe Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. Cukurova Medical Journal 46, no.3 (2021): 975 - 981. 10.17826/cumj.903637
MLA	kul gülnur,Turan Gökçe Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. Cukurova Medical Journal, vol.46, no.3, 2021, ss.975 - 981. 10.17826/cumj.903637
AMA	kul g,Turan G Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. Cukurova Medical Journal. 2021; 46(3): 975 - 981. 10.17826/cumj.903637
Vancouver	kul g,Turan G Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women. Cukurova Medical Journal. 2021; 46(3): 975 - 981. 10.17826/cumj.903637
IEEE	kul g,Turan G "Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women." Cukurova Medical Journal, 46, ss.975 - 981, 2021. 10.17826/cumj.903637
ISNAD	kul, gülnur - Turan, Gökçe. "Comparison of Toxoplasma and Rubella seropositivity rates of Syrian and Turkish pregnant women". Cukurova Medical Journal 46/3 (2021), 975-981. https://doi.org/10.17826/cumj.903637