Aims: Stroke is the third leading cause of disability and the second leading cause of deathworldwide. Due to the effects of different factors on stroke mortality, the present study aimsto determine the in-hospital mortality rate of stroke and its related factors at Ali-Ibn-Abi TalibHospital of Rafsanjan. Methods: In this cross-sectional descriptive study, the records of all dead patients with thediagnosis of stroke at Ali-Ibn-Abi Talib Hospital of Rafsanjan were studied for the period of2012-2017. The inclusion criteria were the definite diagnosis of stroke not longer than 72 hoursfrom the onset of symptoms and being older than 18 years at the time of stroke. The exclusioncriteria included other fatal cerebral lesions, having incomplete information for the records,death at the time of admission, and having an indefinite cause of death. Results: From among 2,199 stroke patients (the mean age was 68.46±15.67, 46% male, 54%female) who were hospitalized, 9.04% (199 patients) died during the hospitalization period.The in-hospital mortality rate was 7.54% (n=142) and 17.98% (n=57) in ischemic stroke andcerebral hemorrhage, respectively. The major risk factor percentages in died patients were68.3% hypertension, 35.7% diabetes mellitus, 18.6% cholesterolemia. The most common fatalcomplications in died patients included neurological complications (48.7%, n=97), infections(23.1%, n=46), cardiac complications (18.1%, n=36), and thromboembolism (5.5%). Conclusions: Our findings are consistent with other studies about risk factors and complicationsof a stroke. We should focus on the prevention of complications in stroke patients by controllingimportant risk factors.