Yıl: 2021 Cilt: 28 Sayı: 3 Sayfa Aralığı: 579 - 585 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.03.196 İndeks Tarihi: 01-12-2021

The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia

Öz:
Aim: The aim of this study was to compare CRP, TNF-α, CMV, Chlamydia pneumonia IgG and IgM levels between preeclamptic anduneventful pregnant womens, to explain the effects of infectious trigger on the placental pathology of preeclampsia.Materials and Methods: All cases of preeclamptic pregnants detected at or referred to Inonu Univrsty Faculty of Medicine Gynaecologyand Obstetric Department between July 2006 and July 2007 were prospectively collected. The study group was a group of 40 womenwho are preeclamptic. The study also included 40 control subjects who were matched for age, gestational age and body mass index.Results: In the preeclamptic group the level of CRP was significantly higher [28 (1.9– 196); vs. 6.2 (1.2–23) (mg/L) (p<0.001)]. Meanplasma TNF-α levels were 0.054 (0.005–1.80) mmol/L’in the study group and 0.305 (0–0.308) mmol/L in normal controls. Therewere no significant differences between the two groups, when the plasma levels of CMV and Chlamydia pneumonia IgG and IgMwere compared (p>0.999 and p=0.385). Plasma H.pylori IgA levels were higher in the study group with the value of [ 14 (35%) vs. 5(12.5%) (p=0.035)].Conclusion: In the present study, serum CRP, TNF-α and H.pylori IgA levels were significantly higher than normal pregnant women.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Özeren S, Çorakçı A, Mercan R, et al. Preeklampsi Patogenezi ve Profilaksisi. MN DOKTOR 1996;4:365- 9.
  • 2. Taner MZ. Gebeliğin hipertansif hastalıkları. Gebelik ve Sistemik Hastalıklar. Yamaç K, Gürsoy R, Çakır N editors 2002;482-511.
  • 3. Stamilio DM, Sehdev HM, Morgan MA, et al. Can antenatal clinical and biochemical markers predict the development of severe preeclampsia?. Am J Obstetrics Gynecol 2000;182:589-94.
  • 4. Myatt L, Miodovnik M. Prediction of preeclampsia Semin Perinatol 1999;23:4557.
  • 5. Taylor RN, Roberts JM, Cunningham GF, et al. Editors. Chesley's hypertensive disorders in pregnancy. Elsevier. 1999.
  • 6. Stamilio DM, Sehdev HM, Morgan MA, et al. Can antenatal clinical and biochemical markers predict the development of severe preeclampsia?. American journal of obstetrics and gynecology 2000;182:589- 94.
  • 7. De Wolf F, Brosens I, Renaer M. Fetal growth retardation and the maternal arterial supply of the human placenta in the absence of sustained hypertension. BJOG: An International Journal of Obstetrics & Gynaecology, 1980;87:678-85.
  • 8. Hertig AT. Vascular pathology in hypertensive albuminuric toxemias of pregnancy. Clinics 4 1945;602.
  • 9. Meekins JW, Pijnenborg R, Hanssens M, et al. Immunohistochemical detection of lipoprotein (a) in the wall of placental bed spiral arteries in normal and severe preeclamptic pregnancies. Placenta, 1994;15:511-24.
  • 10. Ngeh J, Gupta S. Inflammation, infection and antimicrobial therapy in coronary heart disease– where do we currently stand?. Fundamental Clin Pharmacol 2001;15:85-93.
  • 11. Latsios G, Saetta A, Michalopoulos NV, et al. Detection of cytomegalovirus, Helicobacter pylori and Chlamydia pneumoniae DNA in carotid atherosclerotic plaques by the polymerase chain reaction. Acta Cardiol 2004;59:652-7.
  • 12. Adiloglu AK, Ocal A, Can R, et al. Detection of Helicobacter pylori and Chlamydia pneumoniae DNA in human coronary arteries and evaluation of the results with serologic evidence of inflammation. Saudi Med J 2005;26:1068-74.
  • 13. Adiloglu AK, Can R, Nazli C, et al. Ectasia and severe atherosclerosis: relationships with Chlamydia pneumoniae, Helicobacter pylori, and inflammatory markers. Tex Heart Inst J 2005;32:21.
  • 14. Laifer SA, Ehrlich GD, Huff DS, et al. Congenital cytomegalovirus infection in offspring of liver transplant recipients. Clin Infect Dis 1995;20:52-5.
  • 15. Saetta A, Agapitos E, Davaris PS. Determination of CMV placentitis. Virchows Arch 1998;432:159-62.
  • 16. Pampus V, Maria G. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 1999;180:1146- 50.
  • 17. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002;77:67-75.
  • 18. Lefevre G, Berkane N, Uzan S, et al. Prééclampsie et radicaux libres oxygénés. Ann Biol Clin (Paris) 1997;55:443-50.
  • 19. von Dadelszen P, Magee LA, Krajden M, et al. Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia. BJOG 2003;110:725-30.
  • 20. Heine RP, Ness RB, Roberts JM. Seroprevalence of antibodies to Chlamydia pneumoniae in women with preeclampsia. Obstet Gynecol 2003;101:221-6.
  • 21. Raynor BD, Bonney EA, Jang KT, et al. Preeclampsia and Chlamydia pneumoniae: is there a link?. Hypertens Pregnancy 2004;23:129-34.
  • 22. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506.
  • 23. Goulis DG, Chappell L, Gibbs RG, et al. Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre-eclampsia. BJOG 2005;112:299- 305.
  • 24. Tanaka A, Hirota K, Takahashi K, et al. Suppression of cell mediated immunity to cytomegalovirus and tuberculin in pregnancy employing the leukocyte migration inhibition test. Microbiol Immunol 1983;27:937-43.
  • 25. Ponzetto A, Cardaropoli S, Piccoli E, et al. Preeclampsia is associated with Helicobacter pylori seropositivity in Italy. Journal of Hypertension, 2006;24(12), 2445-2449.
  • 26. Vince GS, Starkey PM, Austgulen R, et al. Interleukin-6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995;102:20-5.
  • 27. Pasceri V, Cammarota G, Patti G, et al. Association of virulent Helicobacter pylori strains with ischemic heart disease. Circulation 1998;97:1675-9.
  • 28. Reslan OM, Khalil RA. Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem 2010;8:204- 26.
  • 29. Abbus A, Lichtman A. General properties of the immune response, cells and Tissues of the Immune system. Cellular and Molecular Immunolog. Elsevier Health Sciences: Philadephia, Pennsylvania 2005:189-215.
  • 30. Đuričić S, Stojanov M, Obradović I, et al. Fibronectin and c-reactive protein in pregnancy induced hypertension. Jugoslovenska Medicinska Biohemija 2003;22:325-8.
  • 31. Savvidou MD, Lees CC, Parra M, et al. Levels of C-reactive protein in pregnant women who subsequently develop pre-eclampsia. BJOG 2002;109:297-301.
  • 32. Tjoa ML, Van Vugt JMG, Go ATJJ, et al. Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction. J Reprod Immunol 2003;59:29-37.
  • 33. Üstün Y, Engin-Üstün Y, Kamacı M. Association of fibrinogen and C-reactive protein with severity of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2005;121:154-8.
  • 34. Vickers M, Ford I, Morrison R, et al. Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension. Thromb Haemost 2003;90:1192-7.
  • 35. Sacks GP, Studena K, Sargent IL, et al. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 1998;179:80-6.
  • 36. Carlos PJ, Rudge MVC, Peraçoli MTS. Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia. Am J Reprod Immunol 2007;177-85.
  • 37. Mustaphi R, Gopalan S, Dhaliwal L, et al. Hyperuricaemia and perinatal outcome in pregnancy induced hypertension. J Indian Med Assoc 1994;92:331-2.
  • 38. Yıldız Ç, Karakuş S, Akkar ÖB, et al. The significance of neutrophil-lymphocyte ratio and mean corpuscular volume in diagnosis of preeclampsia. Gynecol Obstet Reproductive Med 2016;22:75-9.
  • 39. Kumru P, Aka N, Köse G, et al. The value of mean platelet volume in predicting the severity of preeclampsia and of Hellp syndrome. Gynecol Obstet Reproductive Med 2007;13:9-13
APA ÖZKAPLAN Ş, TOPDAĞI Y, ÜSTÜN Y (2021). The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. , 579 - 585. 10.5455/annalsmedres.2020.03.196
Chicago ÖZKAPLAN Şükran Esra,TOPDAĞI YUNUS EMRE,ÜSTÜN YUSUF The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. (2021): 579 - 585. 10.5455/annalsmedres.2020.03.196
MLA ÖZKAPLAN Şükran Esra,TOPDAĞI YUNUS EMRE,ÜSTÜN YUSUF The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. , 2021, ss.579 - 585. 10.5455/annalsmedres.2020.03.196
AMA ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. . 2021; 579 - 585. 10.5455/annalsmedres.2020.03.196
Vancouver ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. . 2021; 579 - 585. 10.5455/annalsmedres.2020.03.196
IEEE ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y "The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia." , ss.579 - 585, 2021. 10.5455/annalsmedres.2020.03.196
ISNAD ÖZKAPLAN, Şükran Esra vd. "The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia". (2021), 579-585. https://doi.org/10.5455/annalsmedres.2020.03.196
APA ÖZKAPLAN Ş, TOPDAĞI Y, ÜSTÜN Y (2021). The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. Annals of Medical Research, 28(3), 579 - 585. 10.5455/annalsmedres.2020.03.196
Chicago ÖZKAPLAN Şükran Esra,TOPDAĞI YUNUS EMRE,ÜSTÜN YUSUF The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. Annals of Medical Research 28, no.3 (2021): 579 - 585. 10.5455/annalsmedres.2020.03.196
MLA ÖZKAPLAN Şükran Esra,TOPDAĞI YUNUS EMRE,ÜSTÜN YUSUF The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. Annals of Medical Research, vol.28, no.3, 2021, ss.579 - 585. 10.5455/annalsmedres.2020.03.196
AMA ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. Annals of Medical Research. 2021; 28(3): 579 - 585. 10.5455/annalsmedres.2020.03.196
Vancouver ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia. Annals of Medical Research. 2021; 28(3): 579 - 585. 10.5455/annalsmedres.2020.03.196
IEEE ÖZKAPLAN Ş,TOPDAĞI Y,ÜSTÜN Y "The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia." Annals of Medical Research, 28, ss.579 - 585, 2021. 10.5455/annalsmedres.2020.03.196
ISNAD ÖZKAPLAN, Şükran Esra vd. "The relation of infectious and inflammatory markers withplacental atherosclerosis in preeclampsia". Annals of Medical Research 28/3 (2021), 579-585. https://doi.org/10.5455/annalsmedres.2020.03.196