MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis
Yıl: 2020 Cilt: 45 Sayı: 5 Sayfa Aralığı: 587 - 592 Metin Dili: İngilizce DOI: 10.1515/tjb-2019-0296 İndeks Tarihi: 18-11-2021
MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis
Öz: Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:<0.0001,OR:4.54, CI:2.09–9.88) and MICA*0004 (p:0.01, OR:2.84,CI:1.2–6.7) alleles were higher in patient group.Conclusions: The present study will inform the MICAand HLA genotypes about the protective (DRB1*01,MICA*0002/20/55) or susceptible (DRB1*14, DRB1*15,MICA*0004) alleles of the disease and helps the literatureon Turkish patients with ulcerative colitis.
Anahtar Kelime: Ülseratif kolitli Türk hastalarda MICA, HLA-DRB1, HLA-DQB1 genotipleri
Öz: Amaç: Ülseratif kolit, kronik enflamatuvar bir bağırsak hastalığıdır. HLA alelleri, enflamatuvar bağırsak hasta lıklarının patogenezinde önemli bir rol oynar. HLA DRB1*09, DRB1*1502, DRB1*0103 ve DRB1*13 alellerinin ülseratif kolit ile ilişkili olduğu bildirilirken HLA DRB1*04 ve DRB1*08 alellerinin koruyucu olduğu bil dirilmiştir. Bakteriyel antijenler kolon lümeninde MICA ekspresyonunu indükler ve MICA geni ülseratif kolit gelişimi için önemlidir. MICA*06 ve MICA*007 alelleri Ülseratif kolit ile ilişkilendirilmiştir. Ülseratif kolitli hastalarda HLA-DRB1, DQB1, MICA genotiplerini belir lemeyi amaçladık. Gereç ve yöntemler: Hasta (n: 85) ve kontrol grubunun (n: 100) HLA-DRB1, HLA-DQB1, MICA genotiplemesi PCR-SSO Lumineks (One Lambda genotipleme kiti) yöntemiyle gerçekleştirildi. Bulgular: DRB1*01 (p: 0.022, OR: 0.23, CI: 0.06–0.8) ve MICA*0002/20/55 (p: 0.03, OR: 0.53, CI: 0.29-0.93) allelleri kontrol grubunda anlamlı olarak daha yüksek iken, DRB1*14 (p: 0.04, OR: 2.25, CI: 1–5.08), DRB1*15 (p: <0.0001,OR: 4.54, CI: 2.09–9.88) ve MICA*0004 (p: 0.01, OR: 2.84 , CI: 1.2–6.7) alelleri hasta grubunda daha yüksekti. Sonuç: Bu çalışma, Ülseratif kolitli Türk hastalarda MICA ve HLA genotiplerini hastalığın koruyucu (DRB1*01, MICA*0002/20/55) veya duyarlı (DRB1*14, DRB1*15, MICA*0004) alelleri hakkında bilgilendirecek ve literatüre yardımcı olacaktır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Kekik Çınar C, Demir K, Akyuz F, PINARBAŞI B, TEMURHAN S, SAVRAN OGUZ F (2020). MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. , 587 - 592. 10.1515/tjb-2019-0296 |
Chicago | Kekik Çınar Cigdem,Demir Kadir,Akyuz Filiz,PINARBAŞI Binnur,TEMURHAN Sonay,SAVRAN OGUZ FATMA MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. (2020): 587 - 592. 10.1515/tjb-2019-0296 |
MLA | Kekik Çınar Cigdem,Demir Kadir,Akyuz Filiz,PINARBAŞI Binnur,TEMURHAN Sonay,SAVRAN OGUZ FATMA MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. , 2020, ss.587 - 592. 10.1515/tjb-2019-0296 |
AMA | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. . 2020; 587 - 592. 10.1515/tjb-2019-0296 |
Vancouver | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. . 2020; 587 - 592. 10.1515/tjb-2019-0296 |
IEEE | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F "MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis." , ss.587 - 592, 2020. 10.1515/tjb-2019-0296 |
ISNAD | Kekik Çınar, Cigdem vd. "MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis". (2020), 587-592. https://doi.org/10.1515/tjb-2019-0296 |
APA | Kekik Çınar C, Demir K, Akyuz F, PINARBAŞI B, TEMURHAN S, SAVRAN OGUZ F (2020). MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi, 45(5), 587 - 592. 10.1515/tjb-2019-0296 |
Chicago | Kekik Çınar Cigdem,Demir Kadir,Akyuz Filiz,PINARBAŞI Binnur,TEMURHAN Sonay,SAVRAN OGUZ FATMA MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi 45, no.5 (2020): 587 - 592. 10.1515/tjb-2019-0296 |
MLA | Kekik Çınar Cigdem,Demir Kadir,Akyuz Filiz,PINARBAŞI Binnur,TEMURHAN Sonay,SAVRAN OGUZ FATMA MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi, vol.45, no.5, 2020, ss.587 - 592. 10.1515/tjb-2019-0296 |
AMA | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi. 2020; 45(5): 587 - 592. 10.1515/tjb-2019-0296 |
Vancouver | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi. 2020; 45(5): 587 - 592. 10.1515/tjb-2019-0296 |
IEEE | Kekik Çınar C,Demir K,Akyuz F,PINARBAŞI B,TEMURHAN S,SAVRAN OGUZ F "MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis." Türk Biyokimya Dergisi, 45, ss.587 - 592, 2020. 10.1515/tjb-2019-0296 |
ISNAD | Kekik Çınar, Cigdem vd. "MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis". Türk Biyokimya Dergisi 45/5 (2020), 587-592. https://doi.org/10.1515/tjb-2019-0296 |