Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model
Yıl: 2021 Cilt: 27 Sayı: 4 Sayfa Aralığı: 445 - 454 Metin Dili: İngilizce DOI: 10.9775/kvfd.2021.25516 İndeks Tarihi: 22-11-2021
Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model
Öz: This paper aimed to research the possible eff ects of gossypin in a mechano-bio-regulatory mouse model for bone fracture healing. A total of28 male Mus musculus BALB/c mice were randomly selected. Four groups were created. Each group consisted of 7 mice. The Control groupwas called Group 1. Group 2 was a femur fractured group of mice without any medication. Group 3 was the dose group of 5 mg/kg gossypinto mouse with femur fractures. Group 4 was the dose group of 10 mg/kg gossypin to mouse with femur fractures. An open fracture modelwas created in the right femur of the animals in Groups 2, 3, and 4. The radiological views for all groups were taken on postoperative 1st day,6th week, and 12th week. All samples were obtained, collected, and prepared for biomechanical features, histopathological examinations,biochemical tests, and PCR tests. In terms of radiological and histological results, gossypin showed a significant diff erence depending on thedose in Group 4 to Group 3. Gossypin had sufficient antioxidant and anti-infl ammatory eff ects in mice with femur fracture in bone healing inGroups 3 and 4. Biomechanical tests showed enough hardness levels and high thresholds in braking forces.
Anahtar Kelime: Gossypin’in Fare Mekano-Biyoregülatör Modeli Deneysel Femur Kırıklarında Kırık İyileşmesi Üzerine Etkileri
Öz: Bu çalışma, gossypin’in kemik kırık iyileşmesi için fare mekano-bioregülatör modelinde olası iyileştirici etkilerini araştırmayı amaçladı. Toplam 28 erkek Mus musculus BALB/c faresi rastgele seçildi. Dört grup oluşturuldu. Her grup 7 fare içermekteydi. Kontrol grubu Grup 1 olarak adlandırıldı. Grup 2 herhangi bir ilaç uygulaması yapılmayan femur kırıklı fare grubuydu. Grup 3, 5 mg/kg gossypin uygulanan femur kırıklı fare doz grubuydu. Grup 4, 10 mg/kg gossypin uygulanan femur kırıklı fare doz grubuydu. Grup 2, 3 ve 4’teki hayvanların sağ femurlarında açık kırık modeli oluşturuldu. Postoperatif birinci gün, altıncı ve onikinci hafta sonunda tüm gruplar için radyolojik tetkikler yapıldı. Tüm örnekler alındı, toplandı ve biyomekanik testler, histopatolojik incelemeler, biyokimyasal testler, PCR testleri için hazırlandı. Radyolojik ve histolojik sonuçlar açısından gossypin, doza bağlı olarak önemli bir farklılık göstermiştir. Gossypin, kemik iyileşmesinde femur kırığı olan farelerde yeterli antioksidan ve antiinfl amatuar etkilere sahipti. Biyomekanik testler, yeterli kemik sertlik dereceleri ve kırılma kuvvetlerinde yüksek eşik değerleri gösterdi.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | YILDIZ K, TURALIOĞLU M, Tahiroğlu V, Boy F, Yiğit S (2021). Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. , 445 - 454. 10.9775/kvfd.2021.25516 |
| Chicago | YILDIZ Kadri,TURALIOĞLU Mehmet Fatih,Tahiroğlu Veysel,Boy Fatih,Yiğit Serdar Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. (2021): 445 - 454. 10.9775/kvfd.2021.25516 |
| MLA | YILDIZ Kadri,TURALIOĞLU Mehmet Fatih,Tahiroğlu Veysel,Boy Fatih,Yiğit Serdar Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. , 2021, ss.445 - 454. 10.9775/kvfd.2021.25516 |
| AMA | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. . 2021; 445 - 454. 10.9775/kvfd.2021.25516 |
| Vancouver | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. . 2021; 445 - 454. 10.9775/kvfd.2021.25516 |
| IEEE | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S "Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model." , ss.445 - 454, 2021. 10.9775/kvfd.2021.25516 |
| ISNAD | YILDIZ, Kadri vd. "Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model". (2021), 445-454. https://doi.org/10.9775/kvfd.2021.25516 |
| APA | YILDIZ K, TURALIOĞLU M, Tahiroğlu V, Boy F, Yiğit S (2021). Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27(4), 445 - 454. 10.9775/kvfd.2021.25516 |
| Chicago | YILDIZ Kadri,TURALIOĞLU Mehmet Fatih,Tahiroğlu Veysel,Boy Fatih,Yiğit Serdar Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27, no.4 (2021): 445 - 454. 10.9775/kvfd.2021.25516 |
| MLA | YILDIZ Kadri,TURALIOĞLU Mehmet Fatih,Tahiroğlu Veysel,Boy Fatih,Yiğit Serdar Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.27, no.4, 2021, ss.445 - 454. 10.9775/kvfd.2021.25516 |
| AMA | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(4): 445 - 454. 10.9775/kvfd.2021.25516 |
| Vancouver | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2021; 27(4): 445 - 454. 10.9775/kvfd.2021.25516 |
| IEEE | YILDIZ K,TURALIOĞLU M,Tahiroğlu V,Boy F,Yiğit S "Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 27, ss.445 - 454, 2021. 10.9775/kvfd.2021.25516 |
| ISNAD | YILDIZ, Kadri vd. "Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 27/4 (2021), 445-454. https://doi.org/10.9775/kvfd.2021.25516 |
