Amaç: Hepatosteatosis (HS) is defined as accumulation of fat in liver reaching to an amount of at least 5% of liverweight. Not just mean platelet volume (MPV), but also MPV to lymphocyte ratio (MPVLR) has been introduced asa marker in inflammatory and metabolic conditions. We aimed to compare MPVLR values of patients with hepa tosteatosis with those of healthy controls. We also investigated the correlation between CRP and MPVLRMethods: The data of the patients with HS who were admitted to internal medicine outpatient clinics of our insti tution between 2018 December and 2019 December were enrolled into the study. The MPVLR were calculatedusing MPV/lymphocyte formula. Results: The median MPVLRs of the HS and control groups were 4.3% (2.1) and 3.6% (1.7), respectively (p<0.001).The median CRP levels of the HS and control groups were 3.6 (4.9) mg/L and 0.4 (0.2) mg/L, respectively (p<0.001).The MPVLR was positively and strongly correlated with CRP (r=0.64, p<0.001). However, MPVLR and the biochemi cal parameters; LDL-cholesterol, ALT and triglyceride were not correlated at all.. Conclusion: We suggest that elevated MPVLR should alert physicians for possible hepatosteatosis in a populationwithout comorbidities. Positive and strong correlation between CRP and MPVLR should also prompt use of MPVLRas a reliable inflammatory predictor.