Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Background/aim: Coronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. As a result of high mortality rate among the severe COVID-19 patients, the early detection of the disease stage and early effective interventions are very important in reducing mortality. Hence, it is important to differentiate severe and nonsevere cases from each other. To date, there are no proven diagnostic or prognostic parameters that can be used in this manner. Due to the expensive and not easily accessible tests that are performed for COVID-19, researchers are investigating some parameters that can be easily used. In some recent studies, hematological parameters have been evaluated to see if they can be used as predictive parameters. Materials and methods: In the current study, almost all hematological parameters were used, including the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, mean platelet volume to lymphocyte ratio, mean platelet volume to platelet ratio, plateletcrit, and D-dimer/fibrinogen ratio, neutrophil/lymphocyte/platelet scoring system, and systemic immune-inflammation index. A total of 750 patients, who were admitted to Ankara City Hospital due to COVID-19, were evaluated in this study. The patients were classified into 2 groups according to their diagnosis (confirmed or probable) and into 2 groups according to the stage of the disease (nonsevere or severe). Results: The values of the combinations of inflammatory markers and other hematological parameters in all of the patients with severe COVID-19 were calculated, and the predicted values of these parameters were compared. According to results of the study, nearly all of the hematological parameters could be used as potential diagnostic biomarkers for subsequent analysis, because the area under the curve (AUC) was higher than 0.50, especially for the DFR and NLR, which had the highest AUC among the parameters. Conclusion: Our findings indicate that, the parameters those enhanced from complete blood count, which is a simple laboratory test, can help to identify and classify COVID-19 patients into non-severe to severe groups.Key words: COVID-19, SARS-CoV-2, hematological tests, predictive values of tests

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APA	Şan İ, GEMCİOĞLU E, Davutoğlu M, Çatalbaş R, KARABUĞA B, Kaptan E, erden a, kucuksahin o, ateş i, KARAAHMETOGLU S, Hasanoglu I, İNAN O, Ünal B, ERDEMİR E, Kahraman F, GÜNER R (2021). Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. , 2810 - 2821. 10.3906/sag-2008-6
Chicago	Şan İshak,GEMCİOĞLU EMİN,Davutoğlu Mehmet,Çatalbaş Ramis,KARABUĞA Berkan,Kaptan Enes,erden abdulsamet,kucuksahin orhan,ateş ihsan,KARAAHMETOGLU SELMA,Hasanoglu Imran,İNAN OSMAN,Ünal Büşra nur,ERDEMİR Ecem,Kahraman Fatih Ahmet,GÜNER RAHMET Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. (2021): 2810 - 2821. 10.3906/sag-2008-6
MLA	Şan İshak,GEMCİOĞLU EMİN,Davutoğlu Mehmet,Çatalbaş Ramis,KARABUĞA Berkan,Kaptan Enes,erden abdulsamet,kucuksahin orhan,ateş ihsan,KARAAHMETOGLU SELMA,Hasanoglu Imran,İNAN OSMAN,Ünal Büşra nur,ERDEMİR Ecem,Kahraman Fatih Ahmet,GÜNER RAHMET Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. , 2021, ss.2810 - 2821. 10.3906/sag-2008-6
AMA	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. . 2021; 2810 - 2821. 10.3906/sag-2008-6
Vancouver	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. . 2021; 2810 - 2821. 10.3906/sag-2008-6
IEEE	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R "Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?." , ss.2810 - 2821, 2021. 10.3906/sag-2008-6
ISNAD	Şan, İshak vd. "Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?". (2021), 2810-2821. https://doi.org/10.3906/sag-2008-6

APA	Şan İ, GEMCİOĞLU E, Davutoğlu M, Çatalbaş R, KARABUĞA B, Kaptan E, erden a, kucuksahin o, ateş i, KARAAHMETOGLU S, Hasanoglu I, İNAN O, Ünal B, ERDEMİR E, Kahraman F, GÜNER R (2021). Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. Turkish Journal of Medical Sciences, 51(6), 2810 - 2821. 10.3906/sag-2008-6
Chicago	Şan İshak,GEMCİOĞLU EMİN,Davutoğlu Mehmet,Çatalbaş Ramis,KARABUĞA Berkan,Kaptan Enes,erden abdulsamet,kucuksahin orhan,ateş ihsan,KARAAHMETOGLU SELMA,Hasanoglu Imran,İNAN OSMAN,Ünal Büşra nur,ERDEMİR Ecem,Kahraman Fatih Ahmet,GÜNER RAHMET Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. Turkish Journal of Medical Sciences 51, no.6 (2021): 2810 - 2821. 10.3906/sag-2008-6
MLA	Şan İshak,GEMCİOĞLU EMİN,Davutoğlu Mehmet,Çatalbaş Ramis,KARABUĞA Berkan,Kaptan Enes,erden abdulsamet,kucuksahin orhan,ateş ihsan,KARAAHMETOGLU SELMA,Hasanoglu Imran,İNAN OSMAN,Ünal Büşra nur,ERDEMİR Ecem,Kahraman Fatih Ahmet,GÜNER RAHMET Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. Turkish Journal of Medical Sciences, vol.51, no.6, 2021, ss.2810 - 2821. 10.3906/sag-2008-6
AMA	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. Turkish Journal of Medical Sciences. 2021; 51(6): 2810 - 2821. 10.3906/sag-2008-6
Vancouver	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?. Turkish Journal of Medical Sciences. 2021; 51(6): 2810 - 2821. 10.3906/sag-2008-6
IEEE	Şan İ,GEMCİOĞLU E,Davutoğlu M,Çatalbaş R,KARABUĞA B,Kaptan E,erden a,kucuksahin o,ateş i,KARAAHMETOGLU S,Hasanoglu I,İNAN O,Ünal B,ERDEMİR E,Kahraman F,GÜNER R "Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?." Turkish Journal of Medical Sciences, 51, ss.2810 - 2821, 2021. 10.3906/sag-2008-6
ISNAD	Şan, İshak vd. "Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?". Turkish Journal of Medical Sciences 51/6 (2021), 2810-2821. https://doi.org/10.3906/sag-2008-6