Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19
Yıl: 2021 Cilt: 26 Sayı: 3 Sayfa Aralığı: 378 - 383 Metin Dili: İngilizce DOI: 10.5578/flora.20219705 İndeks Tarihi: 31-12-2021
Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19
Öz: Introduction: In this study, we aimed to compare the place of throat mouthwash in the diagnosis of COVID-19 and the detection values of SARS-Cov-2 in naso-oropharyngeal swab (NOS) and mouthwash samples. Materials and Methods: NOS and mouthwash water samples were taken from the patients simultaneously. Mouthwash sampling was obtained by himself. For the NOS sample; after the swab sample was taken from the patient’s oropharynx with a dacron tip swab, with the same swab. RNA isolation from combined oral/nasal swab samples was performed with the EZ1 (Qiagen, Germany) device. Statistical analyses were performed using the SPSS software version 21.0. Results: The diagnostic efficacy of throat mouthwash and combined NOS samples taken from 106 volunteers were compared (56 males, mean age 42.9 years). The diagnostic sensitivity of the mouthwash was 60.71%, specificity 98.65%, positive predictive value 94.44% and negative predictive value 86.9% compared to the results of the NOS. According to these results, although mouthwash is a specific test, its sensitivity to NOS is not satisfactory. The value of kappa was substantial agreement as 0.668, and it was found statistically significant (<0.001). Conclusion: Throat mouthwash is a promising noninvasive technique for diagnosis, monitoring and infection control in patients with COVID-19 infection and reduces the risk of transmission for the healthcare provider.
Anahtar Kelime: COVID-19 Tanısında Gargara ve Nazo Orofarengeal Sürüntü Örneklerinin Karşılaştırılması
Öz: Giriş: Bu çalışmada boğaz gargarasının COVID-19 tanısındaki yerini, Nazo-orofaringeal sürüntü (NOS) ve gargara suyu örneklerinde SARS-Cov-2’yi saptama değerlerini karşılaştırılmayı amaçladık. Materyal ve Metod: Hastalardan eş zamanlı olarak nazo-orofaringeal sürüntü (NOS) ve gargara suyu (hastanın kendisi tarafından) örnekleri alındı. NOS örneği için; hastanın orofarenksinden dakron uçlu swab ile sürüntü örneği alındıktan sonra, aynı sürüntü çubuğu ile burundan da örnek alındı. Sürüntü örneklerinden RNA izolasyonu EZ1 (Qiagen, Almanya) cihazı ile yapıldı. İstatistiksel analizler SPSS yazılımının 21.0 versiyonu kullanılarak yapıldı. Bulgular: 106 gönüllüden alınan boğaz gargarası ve kombine NOS örneklerinin tanısal etkinliği karşılaştırıldı (56 erkek, ortalama yaş 42.9 yıl). Ağız gargarasının tanısal duyarlılığı NOS sonuçlarına göre %60.71, özgüllük %98.65, pozitif prediktif değer %94.44 ve negatif prediktif değer %86.9 idi. Bu sonuçlara göre gargara spesifik bir test olmasına rağmen NOS’a duyarlılığı tatmin edici değildir. Kappa değeri 0.668 olarak önemli bir uyum ve istatistiksel olarak anlamlı bulunmuştur (<0.001). Sonuç: Boğaz ve ağız gargarası, COVID-19 infeksiyonu olan hastalarda teşhis, izleme ve infeksiyon kontrolü için ümit verici, invazif olmayan bir tekniktir ve sağlık hizmeti sağlayıcısı için bulaşma riskini azaltır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KARABAY O, toptan h, KÖSE E, Guclu E, Koroglu M (2021). Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. , 378 - 383. 10.5578/flora.20219705 |
| Chicago | KARABAY OĞUZ,toptan hande,KÖSE Elif,Guclu Ertugrul,Koroglu Mehmet Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. (2021): 378 - 383. 10.5578/flora.20219705 |
| MLA | KARABAY OĞUZ,toptan hande,KÖSE Elif,Guclu Ertugrul,Koroglu Mehmet Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. , 2021, ss.378 - 383. 10.5578/flora.20219705 |
| AMA | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. . 2021; 378 - 383. 10.5578/flora.20219705 |
| Vancouver | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. . 2021; 378 - 383. 10.5578/flora.20219705 |
| IEEE | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M "Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19." , ss.378 - 383, 2021. 10.5578/flora.20219705 |
| ISNAD | KARABAY, OĞUZ vd. "Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19". (2021), 378-383. https://doi.org/10.5578/flora.20219705 |
| APA | KARABAY O, toptan h, KÖSE E, Guclu E, Koroglu M (2021). Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26(3), 378 - 383. 10.5578/flora.20219705 |
| Chicago | KARABAY OĞUZ,toptan hande,KÖSE Elif,Guclu Ertugrul,Koroglu Mehmet Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26, no.3 (2021): 378 - 383. 10.5578/flora.20219705 |
| MLA | KARABAY OĞUZ,toptan hande,KÖSE Elif,Guclu Ertugrul,Koroglu Mehmet Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.26, no.3, 2021, ss.378 - 383. 10.5578/flora.20219705 |
| AMA | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(3): 378 - 383. 10.5578/flora.20219705 |
| Vancouver | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(3): 378 - 383. 10.5578/flora.20219705 |
| IEEE | KARABAY O,toptan h,KÖSE E,Guclu E,Koroglu M "Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26, ss.378 - 383, 2021. 10.5578/flora.20219705 |
| ISNAD | KARABAY, OĞUZ vd. "Comparison of Mouthwash and Naso-Oropharyngeal Swab Samples in the Diagnosis of COVID-19". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26/3 (2021), 378-383. https://doi.org/10.5578/flora.20219705 |
