Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?

POLAT, Gürbüz; sezgin, melek; ŞAHİN, Günşah; GÜLER, Hayal

Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?

Günşah ŞAHİN, (Mersin Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Mersin, Türkiye)

Hayal GÜLER, (Mersin Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Mersin, Türkiye)

Melek SEZGİN, (Mersin Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Mersin, Türkiye)

Gürbüz POLAT (Mersin Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Mersin, Türkiye)

Romatizma Dergisi

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Yıl: 2005 Cilt: 20 Sayı: 1 Sayfa Aralığı: 27 - 31 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?

Öz:

Bu çalışmada, postmenopozai kadınlarda, serum leptin düzeyinin, kemik mineral yoğunluğunun (KMY) bir belirleyicisi olup olmadığını araştırmayı amaçladık. Kırk osteoporotik kadın hasta (Lomber veya kalça bölgesinde, t skoru <-2.5) ve yaş ve vücut kitle indeksi uyumlu 40 sağlıklı kadın (t skoru >-1) çalışmaya alındı. Tüm kadınlar post-menopozal dönemdey¬di. Serum leptin konsantrasyonu bir gece aç kaldıktan sonra, radioimmunoassay ile ölçüldü. KMY değerleri, lomber bölge, kalça bölgesi (femoral neck) ve tüm vücutta, dual enerji X -ray abzorbsiyometri ile ölçüldü (DEXA NORLAND XR-46). Serum leptin düzeyi açsından gruplar arasında anlamlı fark yoktu (p>0.05). Çalışmamızda, postmenopazal osteoporotik ve non-osteoporotik kadınlarda, serum leptin düzeyi açısından istatiksel olarak anlamlı fark görülmemiştir. Bununla birlikte, leptin kemiği lokal olarak, doku düzeyinde etkiliyebilir. Bu nedenle, kemik mikro çevresinde yapılan, leptin ile ilgili çalışmalar, ümit vericidir.

Anahtar Kelime: Kemik yoğunluğu Leptin Densitometri, x-ışını Osteoporoz, postmenopozal

Konular: Romatoloji

Postmenopozal osteoporotik kadınlarda, leptin kemik mineral yoğunluğunun belirleyicisi mi?

Öz:

In this study, we aimed to investigate the serum leptin level whether it is a determinant of bone mineral density (BMD) in osteoporotic postmenopausal women. Forty (40) osteoporotic female patients (screened according to WHO criteria, t-score < 2.5SD, at lumbar region or femoral neck region) and forty (40) age and body mass index matched healthy female subjectsfserved as control group;t score >-1.0) were studied. All the women were at post-menopausal period. Serum con¬centrations of leptin after an overnight fast were measured by radioimmunoassay BMD values were measured by dual energy X-ray absorptiometry (DEXA, NORLAND XR-46 ) at the lumbar spine, femoral neck and total body. There was no significant difference between groups regarding serum leptin levels (P=0.599). Our study showed that there was no statistically significant difference concerning serum leptin levels in osteoporotic and non-osteoporotic postmenopausal women. However, at a local tissue level, leptin may effect bone. For this reason, leptin related studies at the bone micro-environment are promising

Anahtar Kelime: Osteoporosis, Postmenopausal Bone Density Leptin Densitometry, X-Ray

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ŞAHİN G, GÜLER H, sezgin m, POLAT G (2005). Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. , 27 - 31.
Chicago	ŞAHİN Günşah,GÜLER Hayal,sezgin melek,POLAT Gürbüz Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. (2005): 27 - 31.
MLA	ŞAHİN Günşah,GÜLER Hayal,sezgin melek,POLAT Gürbüz Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. , 2005, ss.27 - 31.
AMA	ŞAHİN G,GÜLER H,sezgin m,POLAT G Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. . 2005; 27 - 31.
Vancouver	ŞAHİN G,GÜLER H,sezgin m,POLAT G Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. . 2005; 27 - 31.
IEEE	ŞAHİN G,GÜLER H,sezgin m,POLAT G "Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?." , ss.27 - 31, 2005.
ISNAD	ŞAHİN, Günşah vd. "Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?". (2005), 27-31.

APA	ŞAHİN G, GÜLER H, sezgin m, POLAT G (2005). Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. Romatizma Dergisi , 20(1), 27 - 31.
Chicago	ŞAHİN Günşah,GÜLER Hayal,sezgin melek,POLAT Gürbüz Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. Romatizma Dergisi 20, no.1 (2005): 27 - 31.
MLA	ŞAHİN Günşah,GÜLER Hayal,sezgin melek,POLAT Gürbüz Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. Romatizma Dergisi , vol.20, no.1, 2005, ss.27 - 31.
AMA	ŞAHİN G,GÜLER H,sezgin m,POLAT G Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. Romatizma Dergisi . 2005; 20(1): 27 - 31.
Vancouver	ŞAHİN G,GÜLER H,sezgin m,POLAT G Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?. Romatizma Dergisi . 2005; 20(1): 27 - 31.
IEEE	ŞAHİN G,GÜLER H,sezgin m,POLAT G "Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?." Romatizma Dergisi , 20, ss.27 - 31, 2005.
ISNAD	ŞAHİN, Günşah vd. "Is leptin a determinant of bone mineral density in post-menopausal women with osteoporosis?". Romatizma Dergisi 20/1 (2005), 27-31.