Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?

Emine Gülçeri GÜLEÇ PEKER (Giresun Üniversitesi, Sağlık Bilimleri Fakültesi, Giresun, Türkiye)
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
5 0
Yıl: 2021 Cilt: 14 Sayı: 1 Sayfa Aralığı: 117 - 131 Metin Dili: İngilizce DOI: 10.18185/erzifbed.845095 İndeks Tarihi: 02-03-2022

Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?

Öz:
Oxidative stress and persistent inflammation play crucial role in the progression of diabetic wound complications. N-Acetylcysteine (NAC) is an amino acid derivative that promotes wound healing because of its ability of antioxidant properties. The aim of this study was to evaluate the effect of systemic NAC administration on oxidative stress, inflammatory markers, and collagen production in diabetic wound healing. Induction of diabetes was done by intraperitoneally administration of streptozotocin in Wistar rats. A dorsal circular wound was created in diabetic rats. After that subjects were treated with NAC (60 mg/kg) intraperitoneally to evaluate the wound healing potential of NAC. In the wound tissues of diabetic rats, lipid peroxidation and inflammatory markers were significantly increased (p<0.05). Superoxide dismutase and catalase activities, glutathione and NOx levels, and collagen production were significantly reduced in diabetic group (p<0.05). NAC administration increased antioxidant status and NOx levels, reduced lipid peroxidation and inflammatory marker levels in treated diabetic group compared to diabetic group (p<0.05). Additionally, in the diabetic NAC treatment group, collagen production was significantly increased and wound area was significantly smaller than diabetic group (p<0.05). Low dose NAC administration was found to be effective in diabetic wound healing by reducing oxidative stress and inflammation and increasing collagen production.
Anahtar Kelime:

Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

Öz:
Oksidatif stres ve kalıcı inflamasyon, diyabetik yara komplikasyonlarının gelişmesinde önemli rol oynar. NAsetilsistein (NAC), antioksidan özelliklerinden dolayı yara iyileşmesini hızlandıran bir amino asit türevidir. Bu çalışmanın amacı, sistemik NAC uygulamasının diyabetik yara iyileşmesinde oksidatif stres, inflamatuar belirteçler ve kollajen üretimi üzerindeki etkisini değerlendirmektir. Wistar sıçanlarda diyabet indüksiyonu, streptozotosinin intraperitoneal olarak uygulanmasıyla yapılmıştır. Diyabetik sıçanlarda dorsal dairesel bir yara oluşturulmuştur. NAC'nin yara iyileştirme potansiyelini değerlendirmek için denekler intraperitoneal olarak NAC (60 mg / kg) ile tedavi edilmiştir. Diyabetik sıçanların yara dokularında lipid peroksidasyonu ve inflamatuar belirteçler önemli ölçüde artmıştır (p<0.05). Diyabetik grupta süperoksit dismutaz ve katalaz aktiviteleri, glutatyon ve NOx seviyeleri ve kollajen üretimi anlamlı olarak azalmıştır (p<0.05). NAC uygulaması, diyabetik gruba kıyasla, tedavi edilen diyabetik grupta antioksidan durumu ve NOx düzeylerini arttırmış, lipid peroksidasyonunu ve inflamatuar belirteç düzeylerini düşürmüştür (p<0.05). Ayrıca diyabetik NAC tedavi grubunda kollajen üretimi anlamlı olarak artmış ve yara alanı diyabetik gruba göre anlamlı olarak küçülmüştür (p<0.05). Düşük doz NAC uygulamasının, oksidatif stresi ve inflamasyonu azaltarak ve kollajen üretimini artırarak diyabetik yara iyileşmesinde etkili olduğu bulunmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÜLEÇ PEKER E (2021). Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. , 117 - 131. 10.18185/erzifbed.845095
Chicago GÜLEÇ PEKER Emine Gülçeri Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. (2021): 117 - 131. 10.18185/erzifbed.845095
MLA GÜLEÇ PEKER Emine Gülçeri Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. , 2021, ss.117 - 131. 10.18185/erzifbed.845095
AMA GÜLEÇ PEKER E Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. . 2021; 117 - 131. 10.18185/erzifbed.845095
Vancouver GÜLEÇ PEKER E Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. . 2021; 117 - 131. 10.18185/erzifbed.845095
IEEE GÜLEÇ PEKER E "Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?." , ss.117 - 131, 2021. 10.18185/erzifbed.845095
ISNAD GÜLEÇ PEKER, Emine Gülçeri. "Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?". (2021), 117-131. https://doi.org/10.18185/erzifbed.845095
APA GÜLEÇ PEKER E (2021). Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 14(1), 117 - 131. 10.18185/erzifbed.845095
Chicago GÜLEÇ PEKER Emine Gülçeri Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 14, no.1 (2021): 117 - 131. 10.18185/erzifbed.845095
MLA GÜLEÇ PEKER Emine Gülçeri Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol.14, no.1, 2021, ss.117 - 131. 10.18185/erzifbed.845095
AMA GÜLEÇ PEKER E Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 14(1): 117 - 131. 10.18185/erzifbed.845095
Vancouver GÜLEÇ PEKER E Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2021; 14(1): 117 - 131. 10.18185/erzifbed.845095
IEEE GÜLEÇ PEKER E "Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?." Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 14, ss.117 - 131, 2021. 10.18185/erzifbed.845095
ISNAD GÜLEÇ PEKER, Emine Gülçeri. "Does Low Dose N-Acetylcysteine Administration Enhance Diabetic Wound Healing?". Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 14/1 (2021), 117-131. https://doi.org/10.18185/erzifbed.845095
Sayfa Oluşturulma Tarihi
17-04-2024 22:51

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