Yıl: 2021 Cilt: 30 Sayı: 4 Sayfa Aralığı: 326 - 332 Metin Dili: İngilizce DOI: 10.5 152/t urkjn ephro l.202 1.211 43 İndeks Tarihi: 06-01-2022

Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?

Öz:
Coronavirus disease 2019 (COVID-19) has been accepted as a global pandemic, and poses a greater risk to the elderly and those with comorbidities. Comorbid diseases (particularly end-stage kidney disease with hemodialysis) and impaired immunity place patients in the high-risk group for COVID-19. In recent studies, it was also mentioned that exaggerated inflammation and a cytokine storm were the underlying causes related to the high mortality in COVID-19 patients. Currently, treatment modalities to balance the immune system of such vulnerable patient groups are essential, to protect them from the disease. Several vitamins (like vitamins C, D, and E), trace elements like zinc, and probiotics have been proposed as immune boosters to protect and combat infectious conditions. It is well known that these vitamins and elements are insufficient in hemodialysis patients. In this review, we aimed to evaluate the immune-boosting mechanisms of vitamins C, D, E, zinc, and probiotics, the studies related to their beneficial effects against infections, and their possible benefits for hemodialysis patients during the COVID-19 pandemic.
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  • 1. Ikizler TA. COVID-19 and dialysis units: What do we know now and what should we do? Am J Kidney Dis. 2020;S0272-6386(20):30608- 30609. [CrossRef]
  • 2. Sharif MR, Chitsazian Z, Moosavian M, et al. Einollahi B. Immune disorders in hemodialysis patients. Iran J Kidney Dis. 2015;9(2):84-96.
  • 3. Mehta P, McAuley DF, Brown M, HLH Across Speciality Collaboration, UK, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033-1034. [CrossRef]
  • 4. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: Vitamins A and D take centre stage. Nat Rev Immunol. 2008;8(9):685-698. [CrossRef]
  • 5. Barazzoni R, Bischoff SC, Breda J, endorsed by the ESPEN Council, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin Nutr. 2020;S0261-5614(20):30140-30140.
  • 6. Ang A, Pullar JM, Currie MJ, Vissers MCM. Vitamin C and immune cell function in inflammation and cancer. Biochem Soc Trans. 2018;46(5):1147-1159. [CrossRef]
  • 7. van Gorkom GNY, Klein Wolterink RGJ, Van Elssen CHMJ, et al. Influence of vitamin C on lymphocytes: an overview. Antioxidants (Basel). 2018;7(3):41. [CrossRef]
  • 8. Gao YL, Lu B, Zhai JH, et al. The parenteral vitamin C improves sepsis and sepsis-induced multiple organ dysfunction syndrome via preventing cellular immunosuppression. Mediators Inflamm. 2017;2017:4024672. [CrossRef]
  • 9. Anderson R. The immunostimulatory, anti-inflammatory and antiallergic properties of ascorbate. Adv Nutr Res. 1984;6:19-45. [CrossRef]
  • 10. Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211. [CrossRef]
  • 11. Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database Syst Rev. 2013;8:CD005532. [CrossRef]
  • 12. Hemilä H. Vitamin C and SARS coronavirus. J Antimicrob Chemother. 2003;52(6):1049-1050. [CrossRef]
  • 13. Hemilä H. Vitamin C supplementation and respiratory infections: A systematic review. Mil Med. 2004;169(11):920-925. [CrossRef]
  • 14. Carr AC. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care. 2020;24(1):133. [CrossRef]
  • 15. Handelman GJ. Vitamin C deficiency in dialysis patients--are we perceiving the tip of an iceberg? Nephrol Dial Transplant. 2007;22(2):328-331. [CrossRef]
  • 16. Fumeron C, Nguyen-Khoa T, Saltiel C, et al. Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients. Nephrol Dial Transplant. 2005;20(9):1874- 1879. [CrossRef]
  • 17. Coombes JS, Fassett RG. Antioxidant therapy in hemodialysis patients: a systematic review. Kidney Int. 2012;81(3):233-246. [CrossRef]
  • 18. Brant EB, Angus DC. Is high-dose vitamin C beneficial for patients with sepsis? JAMA. 2019;322(13):1257-1258. [CrossRef]
  • 19. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266- 281. [CrossRef]
  • 20. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338(12):777-783. [CrossRef]
  • 21. Deluca HF, Cantorna MT. Vitamin D: Its role and uses in immunology. FASEB J. 2001;15(14):2579-2585. [CrossRef]
  • 22. Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM. Specific high-affinity receptors for 1, 25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.J Clin Endocrinol Metab. 1983;57(6):1308-1310. [CrossRef]
  • 23. Lysandropoulos AP, Jaquiéry E, Jilek S, et al. Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects. J Neuroimmunol. 2011;233(1-2):240-244. [CrossRef]
  • 24. Cantorna MT, Yu S, Bruce D. The paradoxical effects of vitamin D on type 1-mediated immunity. Mol Aspects Med. 2008;29(6):369- 375. [CrossRef]
  • 25. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770-1773. [CrossRef]
  • 26. Beisswenger C, Bals R. Antimicrobial peptides in lung inflammation. Chem Immunol Allergy. 2005;86:55-71. [CrossRef]
  • 27. Aloia JF, Li-Ng M. Re: Epidemic influenza and vitamin D. Epidemiol Infect. 2007;135(7):1095-1096. [CrossRef]
  • 28. Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: A systematic review of randomized controlled trials. Endocr Pract. 2009;15(5):438-449. [CrossRef]
  • 29. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015;7(6):4240-4270. [CrossRef]
  • 30. Mirzavandi F, Talenezhad N, Razmpoosh E, Nadjarzadeh A, Mozaffari- Khosravi H. The effect of intramuscular megadose of vitamin D injections on E-selectin, CRP and biochemical parameters in vitamin D-deficient patients with type-2 diabetes mellitus A randomized controlled trial. Complement Ther Med. 2020;49:102346. [CrossRef]
  • 31. Li L, Lin M, Krassilnikova M, et al. Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: Data from a randomized controlled pilot trial. PLOS ONE. 2014;9(10):e109998. [CrossRef]
  • 32. Su G, Liu Z, Qin X, et al. Vitamin D deficiency and treatment versus risk of infection in end-stage renal disease patients under dialysis: a systematic review and meta-analysis. Nephrol Dial Transplant. 2019;34(1):146-156. [CrossRef]
  • 33. Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007;27:347-362. [CrossRef]
  • 34. Lee GY, Han SN. The role of vitamin E in immunity. Nutrients. 2018;10(11):[CrossRef]. [CrossRef]
  • 35. Hayek MG, Taylor SF, Bender BS, et al. Vitamin E supplementation decreases lung virus titers in mice infected with influenza. J Infect Dis. 1997;176(1):273-276. [CrossRef]
  • 36. Han SN, Wu D, Ha WK, et al. Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology. 2000;100(4):487-493. [CrossRef]
  • 37. Hemilä H. Vitamin E administration may decrease the incidence of pneumonia in elderly males. Clin Interv Aging. 2016;11:1379-1385. [CrossRef]
  • 38. Kiaii M, Aritomi M, Nagase M, Farah M, Jung B. Clinical evaluation of performance, biocompatibility, and safety of vitamin E-bonded polysulfone membrane hemodialyzer compared to non-vitamin E-bonded hemodialyzer. J Artif Organs. 2019;22(4):307-315. [CrossRef]
  • 39. Livingstone C. Zinc: Physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015;30(3):371-382. [CrossRef]
  • 40. Wessels I, Maywald M, Rink L. Zinc as a gatekeeper of immune function. Nutrients. 2017;9(12):1286. [CrossRef]
  • 41. Yakoob MY, Theodoratou E, Jabeen A, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011;11(suppl 3):S23. [CrossRef]
  • 42. Lassi ZS, Moin A, Bhutta ZA. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2016;12(12):CD005978. [CrossRef]
  • 43. Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double- blind and placebo-controlled trials. Clin Respir J. 2018;12(3):857-864. [CrossRef]
  • 44. Skarupskiene I, Kuzminskis V, Abdrachmanovas O, Ryselis S, Smalinskiene A.[Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections]. Medicina (Kaunas). 2005;41(suppl 1):65-68.
  • 45. Yang CY, Wu ML, Chou YY, et al. Essential trace element status and clinical outcomes in long-term dialysis patients: A two-year prospective observational cohort study.Clin Nutr. 2012;31(5):630-636. [CrossRef]
  • 46. Maassen CBM, van Holten-Neelen C, Balk F, et al. Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains. Vaccine. 2000;18(23):2613- 2623. [CrossRef]
  • 47. Madsen K. Probiotics and the immune response. J Clin Gastroenterol. 2006;40(3):232-234. [CrossRef]
  • 48. Bae JY, Kim JI, Park S, et al. Effects of Lactobacillus plantarum and Leuconostoc mesenteroides probiotics on Human Seasonal and Avian Influenza Viruses. J Microbiol Biotechnol. 2018;28(6):893- 901. [CrossRef]
  • 49. Kawahara T, Takahashi T, Oishi K, et al. Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model. Microbiol Immunol. 2015;59(1):1-12. [CrossRef]
  • 50. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-e179. [CrossRef]
  • 51. Waki N, Yajima N, Suganuma H, et al. Oral administration of Lactobacillus brevis KB290 to mice alleviates clinical symptoms following influenza virus infection. Lett Appl Microbiol. 2014;58(1):87- 93. [CrossRef]
  • 52. Vaziri ND, Wong J, Pahl M, et al. Chronic kidney disease alters intestinal microbial flora. Kidney Int. 2013;83(2):308-315. [CrossRef]
  • 53. Vitetta L, Gobe G. Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics. Mol Nutr Food Res. 2013;57(5):824-832. [CrossRef]
APA Gungor O, ULU M, Hasbal N, Onan E, TURGUT D, ARICI M (2021). Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. , 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
Chicago Gungor Ozkan,ULU MEMNUNE SENA,Hasbal Nuri Baris,Onan Engin,TURGUT DİDEM,ARICI Mustafa Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. (2021): 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
MLA Gungor Ozkan,ULU MEMNUNE SENA,Hasbal Nuri Baris,Onan Engin,TURGUT DİDEM,ARICI Mustafa Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. , 2021, ss.326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
AMA Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. . 2021; 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
Vancouver Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. . 2021; 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
IEEE Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M "Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?." , ss.326 - 332, 2021. 10.5 152/t urkjn ephro l.202 1.211 43
ISNAD Gungor, Ozkan vd. "Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?". (2021), 326-332. https://doi.org/10.5 152/t urkjn ephro l.202 1.211 43
APA Gungor O, ULU M, Hasbal N, Onan E, TURGUT D, ARICI M (2021). Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. Turkish journal of nephrology (Online), 30(4), 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
Chicago Gungor Ozkan,ULU MEMNUNE SENA,Hasbal Nuri Baris,Onan Engin,TURGUT DİDEM,ARICI Mustafa Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. Turkish journal of nephrology (Online) 30, no.4 (2021): 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
MLA Gungor Ozkan,ULU MEMNUNE SENA,Hasbal Nuri Baris,Onan Engin,TURGUT DİDEM,ARICI Mustafa Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. Turkish journal of nephrology (Online), vol.30, no.4, 2021, ss.326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
AMA Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. Turkish journal of nephrology (Online). 2021; 30(4): 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
Vancouver Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?. Turkish journal of nephrology (Online). 2021; 30(4): 326 - 332. 10.5 152/t urkjn ephro l.202 1.211 43
IEEE Gungor O,ULU M,Hasbal N,Onan E,TURGUT D,ARICI M "Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?." Turkish journal of nephrology (Online), 30, ss.326 - 332, 2021. 10.5 152/t urkjn ephro l.202 1.211 43
ISNAD Gungor, Ozkan vd. "Do Hemodialysis Patients Need Immune Boosting with Vitamin, Mineral, and Probiotic Supplementation during COVID-19 Pandemic?". Turkish journal of nephrology (Online) 30/4 (2021), 326-332. https://doi.org/10.5 152/t urkjn ephro l.202 1.211 43