Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits
Yıl: 2021 Cilt: 30 Sayı: 4 Sayfa Aralığı: 269 - 278 Metin Dili: İngilizce DOI: 10.5 152/t urkjn ephro l.202 1.21637 İndeks Tarihi: 06-01-2022
Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits
Öz: Objective: To conduct a histopathologic examination of the effects of a combination of parenteral nutrition (PN) and starvation on rabbits’ kidney tissue using light microscopy and transmission electron microscopy. Methods: Four groups consisting of equal numbers of adult female and male New Zealand rabbits were formed (n = 14 each). Rabbits in the PN + oral feeding group were provided with half of their daily caloric needs from rabbit feed and the other half through PN. Rabbits in the PN + starvation group received a full dose of PN daily and received no feed. Rabbits in the half-starvation group were provided with rabbit feed covering only half their daily caloric needs. Rabbits in the control group were provided with all their caloric needs from rabbit feed. After 10 days, all the rabbits were weighed, anesthetized, and euthanized, and their kidney tissue samples were collected. Histopathologic examination was performed by a surgical pathologist blinded to the experimental groups. Results: The kidney tissue samples of rabbits in the PN + starvation group showed mild tubular dilatation, mild tubular degeneration, moderate renal inflammation, mild interstitial fibrosis, and increased apoptosis. The destructive effects were considerably milder in the PN + oral feeding group. Conclusion: PN combined with starvation can cause devastating damage to the kidneys. The damage can be minimized by combining PN with enteral nutrition.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Dudrick SJ. Early developments and clinical applications of total parenteral nutrition. JPEN J Parenter Enteral Nutr. 2003;27(4):291–299. [CrossRef]
- 2. TeitelbaumDH, Coran AG. Nutritional Support. Grosfeld JL, O’Neill JA, Fonkalsrud EW, Coran AG eds. Textbook of Pediatric Surgery. Philadelphia: Mosby; 2006; Vol. 1, Chap.12; p: 194–220.
- 3. Ward N. Nutrition support to patients undergoing gastrointestinal surgery. Nutr J. 2003;2:18. [CrossRef]
- 4. Demircan M, Gürünlüoğlu K, Karaman A, Mızrak B. Damaging effects of total parenteral nutrition Formula on vascular endothelium. J Pediatr Gastroenterol Nutr. 2015;61(4):464–468. [CrossRef]
- 5. Buchman AL, Neely M, Grossie Jr VB, et al. Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats. Nutrition. 2001;17(7-8):600–606. [CrossRef]
- 6. Gürünlüoğlu K, Gül M, Koçbıyık A, et al. Investigation of the cardiotoxic effects of parenteral nutrition in rabbits. J Pediatr Surg. 2020;55(3):465–474. [CrossRef]
- 7. Wildhaber BE, Lynn KN, Yang H, Teitelbaum DH. Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: regulation by the Bcl-2 protein family. Pediatr Surg Int. 2002;18(7):570–575. [CrossRef]
- 8. Wang H, Khaoustov VI, Krishnan B, et al. Total parenteral nutrition induces liver steatosis and apoptosis in neonatal piglets. J Nutr. 2006;136(10):2547–2552. [CrossRef]
- 9. Demircan M, Ergün O, Coker C, et al. Aluminium in total parenteral nutrition solutions produces portal inflammation in rats. J Pediatr Gastroenterol Nutr. 1998;26(3):274–278. [CrossRef]
- 10. Zhao J, Wang L, Cao AL, et al. HuangQi decoction ameliorates renal fibrosis via TGF-ꞵ/smad signaling pathway in vivo and invitro. Cell Physiol Biochem. 2016;38(5):1761–1774. [CrossRef]
- 11. Kar F, Hacioğlu C, Senturk H, Donmez DB, Kanbak G. The role of oxidative stress, renal inflammation, and apoptosis in post ischemic reperfusion injury of kidney tissue: the protective effect of dose-dependent boric acid administration. Biol Trace Elem Res. 2020;195(1):150–158. [CrossRef]
- 12. Archana M, Bastian, Yogesh TL, Kumaraswamy KL. Various methods available for detection of apoptotic cells—a review. Indian J Cancer. 2013;50(3):274–283. [CrossRef]
- 13. Yang B, Johnson TS, Thomas GL, et al. Apoptosis and caspase-3 in experimental anti-glomerular basement membrane nephritis. J Am Soc Nephrol. 2001;12(3):485–495. [CrossRef]
- 14. Holden WD, Krieger H, Levey S, Abbott WE. The effects of nutrition on nitrogen metabolism in the surgical patient. Ann Surg. 1957;146(4):563-77; discussion 577. [CrossRef]
- 15. Zhu X, Zhang X, Yu L, et al. Hepatic overexpression of GRP94 in a rabbit model of parenteral nutrition-associated liver disease. Gastroenterol Res Pract. 2015;2015:269831. [CrossRef]
- 16. Fernandes PC, Dolinger EJ, Abdallah VO, et al. Late onset sepsis and intestinal bacterial colonization in very low birth infants receiving long-term parenteral nutrition. Rev Soc Bras Med Trop. 2011;44(4):447–450. [CrossRef]
- 17. Dudley J, Rogers R, Sealy L. Renal consequences of parenteral nutrition. Pediatr Nephrol. 2014;29(3):375–385. [CrossRef]
- 18. Moukarzel AA, Ament ME, Buchman A, Dahlstrom KA, Vargas J. Renal function of children receiving long-term parenteral nutrition. J Pediatr. 1991;119(6):864–868. [CrossRef]
- 19. Buchman AL, Moukarzel A, Ament ME, et al. Serious renal impairment is associated with long-term parenteral nutrition. JPEN J Parenter Enter Nutr. 1993;17(5):438–444. [CrossRef]
- 20. Lauverjat M, Hadj Aissa A, Vanhems P, et al. Chronic dehydration may impair renal function in patients with chronic intestinal failure on long-term parenteral nutrition. Clin Nutr. 2006;25(1):75–81. [CrossRef]
- 21. Tabel Y, Oncul M, Akin IM, Karabulut AB, Gungor S. Effects of total parenteral nutrition on renal function in preterm neonate. Pediatr Nephrol. 1976;25:2010.
- 22. Pironi L, Lauro A, Soverini V, et al. Renal function in patients on long-term home parenteral nutrition and in intestinal transplant recipients. Nutrition. 2014;30(9):1011–1014. [CrossRef]
- 23. Messova A, Dziubak R, Köglmeier J. Renal function in children on long-term home parenteral nutrition. Front Pediatr. 2019;7:137. [CrossRef]
- 24. Btaiche IF, Khalidi N. Metabolic complications of parenteral nutrition in adults, part 1. Am J Health Syst Pharm. 2004;61(18):1938–1949. doi:[CrossRef])
- 25. Perrone S, Salvi G, Bellieni CV, Buonocore G. Oxidative stress and nutrition in the preterm newborn. J Pediatr Gastroenterol Nutr. 2007;45(suppl 3):S178–S182. [CrossRef]
- 26. Derde S, Vanhorebeek I, Ververs EJ, et al. Increasing intravenous glucose load in the presence of normoglycemia: effect on outcome and metabolism in critically ill rabbits. Crit Care Med. 2010;38(2):602–611. [CrossRef]
- 27. Wang J, Yue X, Meng C, et al. Acute hyperglycemia may induce renal tubular injury through mitophagy inhibition. Front Endocrinol (Lausanne). 2020;11:536213. [CrossRef]
- 28. Weekers F, Giulietti AP, Michalaki M, et al. Metabolic, endocrine and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology. 2003;144(12):5329–5338. [CrossRef]
- 29. Jiang JS, Chou HC, Yeh TF, Chen CM. Neonatal hyperoxia induces kidney fibrosis in rats. Pediatr Neonatol. 2015;56(4):235–241. [CrossRef]
- 30. Schepens MAA, Roelofs HMJ, Peters WH, Wanten GJA. No evidence for oxidative stress in patients on home parenteral nutrition. Clin Nutr. 2006;25(6):939–948. [CrossRef]
| APA | GÜRÜNLÜOĞLU S, Gül M, Gozukara Bag H (2021). Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. , 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| Chicago | GÜRÜNLÜOĞLU SEMRA,Gül Mehmet,Gozukara Bag Harika Gozde Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. (2021): 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| MLA | GÜRÜNLÜOĞLU SEMRA,Gül Mehmet,Gozukara Bag Harika Gozde Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. , 2021, ss.269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| AMA | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. . 2021; 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| Vancouver | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. . 2021; 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| IEEE | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H "Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits." , ss.269 - 278, 2021. 10.5 152/t urkjn ephro l.202 1.21637 |
| ISNAD | GÜRÜNLÜOĞLU, SEMRA vd. "Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits". (2021), 269-278. https://doi.org/10.5 152/t urkjn ephro l.202 1.21637 |
| APA | GÜRÜNLÜOĞLU S, Gül M, Gozukara Bag H (2021). Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. Turkish journal of nephrology (Online), 30(4), 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| Chicago | GÜRÜNLÜOĞLU SEMRA,Gül Mehmet,Gozukara Bag Harika Gozde Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. Turkish journal of nephrology (Online) 30, no.4 (2021): 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| MLA | GÜRÜNLÜOĞLU SEMRA,Gül Mehmet,Gozukara Bag Harika Gozde Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. Turkish journal of nephrology (Online), vol.30, no.4, 2021, ss.269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| AMA | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. Turkish journal of nephrology (Online). 2021; 30(4): 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| Vancouver | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits. Turkish journal of nephrology (Online). 2021; 30(4): 269 - 278. 10.5 152/t urkjn ephro l.202 1.21637 |
| IEEE | GÜRÜNLÜOĞLU S,Gül M,Gozukara Bag H "Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits." Turkish journal of nephrology (Online), 30, ss.269 - 278, 2021. 10.5 152/t urkjn ephro l.202 1.21637 |
| ISNAD | GÜRÜNLÜOĞLU, SEMRA vd. "Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits". Turkish journal of nephrology (Online) 30/4 (2021), 269-278. https://doi.org/10.5 152/t urkjn ephro l.202 1.21637 |
