Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients

YİS, Özgür Mehmet; BUĞDAYCI, Güler; Erdogan, Utku Gorkem; Ateş, Merve; Alisik, Murat; SERT, Mehmet Alp

doi:10.14744/ijmb.2021.03164

Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients

Murat ALIŞIK, (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

Utku Görkem ERDOĞAN, (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

Merve ATEŞ, (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

Mehmet Alp SERT, (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

Özgür Mehmet YİS, (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

Güler BUĞDAYCI (Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Biyokimya Anabilim Dalı, Bolu, Türkiye)

International Journal of Medical Biochemistry

9 1

Yıl: 2021 Cilt: 4 Sayı: 3 Sayfa Aralığı: 143 - 149 Metin Dili: İngilizce DOI: 10.14744/ijmb.2021.03164 İndeks Tarihi: 03-02-2022

Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients

Öz:

Objectives: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR),complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), plate let-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hos pital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare theseparameters between subgroups according to disease severity. In addition, these parameters were evaluated for predic tive value related to the severity of COVID‐19. Methods: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time poly merase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Out patient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moder ate group, and patients admitted to the intensive care unit were categorized in the severe group. Results: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in thestudy. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil,lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group thanthe COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR lev els than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analy sis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845,0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19patients. Conclusion: The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the timeof admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease moni toring.

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APA	Alisik M, Erdogan U, Ateş M, SERT M, YİS Ö, BUĞDAYCI G (2021). Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. , 143 - 149. 10.14744/ijmb.2021.03164
Chicago	Alisik Murat,Erdogan Utku Gorkem,Ateş Merve,SERT Mehmet Alp,YİS Özgür Mehmet,BUĞDAYCI Güler Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. (2021): 143 - 149. 10.14744/ijmb.2021.03164
MLA	Alisik Murat,Erdogan Utku Gorkem,Ateş Merve,SERT Mehmet Alp,YİS Özgür Mehmet,BUĞDAYCI Güler Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. , 2021, ss.143 - 149. 10.14744/ijmb.2021.03164
AMA	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. . 2021; 143 - 149. 10.14744/ijmb.2021.03164
Vancouver	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. . 2021; 143 - 149. 10.14744/ijmb.2021.03164
IEEE	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G "Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients." , ss.143 - 149, 2021. 10.14744/ijmb.2021.03164
ISNAD	Alisik, Murat vd. "Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients". (2021), 143-149. https://doi.org/10.14744/ijmb.2021.03164

APA	Alisik M, Erdogan U, Ateş M, SERT M, YİS Ö, BUĞDAYCI G (2021). Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. International Journal of Medical Biochemistry, 4(3), 143 - 149. 10.14744/ijmb.2021.03164
Chicago	Alisik Murat,Erdogan Utku Gorkem,Ateş Merve,SERT Mehmet Alp,YİS Özgür Mehmet,BUĞDAYCI Güler Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. International Journal of Medical Biochemistry 4, no.3 (2021): 143 - 149. 10.14744/ijmb.2021.03164
MLA	Alisik Murat,Erdogan Utku Gorkem,Ateş Merve,SERT Mehmet Alp,YİS Özgür Mehmet,BUĞDAYCI Güler Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. International Journal of Medical Biochemistry, vol.4, no.3, 2021, ss.143 - 149. 10.14744/ijmb.2021.03164
AMA	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. International Journal of Medical Biochemistry. 2021; 4(3): 143 - 149. 10.14744/ijmb.2021.03164
Vancouver	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients. International Journal of Medical Biochemistry. 2021; 4(3): 143 - 149. 10.14744/ijmb.2021.03164
IEEE	Alisik M,Erdogan U,Ateş M,SERT M,YİS Ö,BUĞDAYCI G "Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients." International Journal of Medical Biochemistry, 4, ss.143 - 149, 2021. 10.14744/ijmb.2021.03164
ISNAD	Alisik, Murat vd. "Predictive value of immature granulocyte count and other inflammatory parameters for disease severity inCOVID‐19 patients". International Journal of Medical Biochemistry 4/3 (2021), 143-149. https://doi.org/10.14744/ijmb.2021.03164