Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress

EREL, Ozcan; Özbek, Betül; KOCA, CEMILE; BALIK, Ahmet Rıfat; Yilmaz, Gulsen; Ersoy, Reyhan

doi:10.14744/ijmb.2021.53825

Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress

Ahmet Rıfat BALIK, (Sağlık Bilimleri Üniversitesi, Gülhane Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Betül ÖZBEK İPTEÇ, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Gülşen YILMAZ, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Özcan EREL, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Cemile BİÇER, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Reyhan ERSOY (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Ankara, Türkiye)

International Journal of Medical Biochemistry

2 0

Yıl: 2021 Cilt: 4 Sayı: 3 Sayfa Aralığı: 185 - 191 Metin Dili: İngilizce DOI: 10.14744/ijmb.2021.53825 İndeks Tarihi: 03-02-2022

Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress

Öz:

Objectives: Oxidative stress has a central role in metabolic disorders associated with high-carbohydrate, ani mal-based-protein diets, and excessive fat consumption. However, the molecular mechanisms of nutrition-mediatedoxidative stress are complex and not fully understood. Dynamic thiol-disulfide homeostasis (DTDH) is the regulationof a balance between thiols and their oxidized forms, and includes the reversal of thiol oxidation in proteins. This studywas an evaluation of DTDH and postprandial oxidative stress. Methods: A total of 86 participants (43 males and 43 females), were included in the study. Fasting and non-fastingblood samples were collected and the native thiol, total thiol, and disulfide parameters were analyzed. Statistical anal yses were performed using IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA). Results: The findings indicated that while the native thiol values were significantly lower in the postprandial samples,the disulfide values were significantly higher. There was no significant difference in the total thiol values. Conclusion: Examination of the DTDH revealed that the oxidative stress level increased following food intake. Proteinthiols involved in antioxidant defense were oxidized and transformed into disulfides.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BALIK A, Özbek B, Yilmaz G, EREL O, KOCA C, Ersoy R (2021). Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. , 185 - 191. 10.14744/ijmb.2021.53825
Chicago	BALIK Ahmet Rıfat,Özbek Betül,Yilmaz Gulsen,EREL Ozcan,KOCA CEMILE,Ersoy Reyhan Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. (2021): 185 - 191. 10.14744/ijmb.2021.53825
MLA	BALIK Ahmet Rıfat,Özbek Betül,Yilmaz Gulsen,EREL Ozcan,KOCA CEMILE,Ersoy Reyhan Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. , 2021, ss.185 - 191. 10.14744/ijmb.2021.53825
AMA	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. . 2021; 185 - 191. 10.14744/ijmb.2021.53825
Vancouver	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. . 2021; 185 - 191. 10.14744/ijmb.2021.53825
IEEE	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R "Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress." , ss.185 - 191, 2021. 10.14744/ijmb.2021.53825
ISNAD	BALIK, Ahmet Rıfat vd. "Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress". (2021), 185-191. https://doi.org/10.14744/ijmb.2021.53825

APA	BALIK A, Özbek B, Yilmaz G, EREL O, KOCA C, Ersoy R (2021). Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry, 4(3), 185 - 191. 10.14744/ijmb.2021.53825
Chicago	BALIK Ahmet Rıfat,Özbek Betül,Yilmaz Gulsen,EREL Ozcan,KOCA CEMILE,Ersoy Reyhan Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry 4, no.3 (2021): 185 - 191. 10.14744/ijmb.2021.53825
MLA	BALIK Ahmet Rıfat,Özbek Betül,Yilmaz Gulsen,EREL Ozcan,KOCA CEMILE,Ersoy Reyhan Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry, vol.4, no.3, 2021, ss.185 - 191. 10.14744/ijmb.2021.53825
AMA	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry. 2021; 4(3): 185 - 191. 10.14744/ijmb.2021.53825
Vancouver	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress. International Journal of Medical Biochemistry. 2021; 4(3): 185 - 191. 10.14744/ijmb.2021.53825
IEEE	BALIK A,Özbek B,Yilmaz G,EREL O,KOCA C,Ersoy R "Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress." International Journal of Medical Biochemistry, 4, ss.185 - 191, 2021. 10.14744/ijmb.2021.53825
ISNAD	BALIK, Ahmet Rıfat vd. "Examination of fasting and postprandial dynamic thioldisulfide homeostasis and oxidative stress". International Journal of Medical Biochemistry 4/3 (2021), 185-191. https://doi.org/10.14744/ijmb.2021.53825