This study aimed to determine the relationship between some demographic characteristics and fear of disease and hygiene behaviour that could affect COVID-19 vaccine hesitancy. The study was performed in 2021 using convenience sampling method. The researchers from the Departments of Public Health of Çukurova and İnönü Universities e-mailed an online questionnaire to medicine and health sciences students who were asked to forward it to people they communicate with through online platforms like e-mail, WhatsApp, instagram, facebook. The data collected by sociodemographic questionnaire, COVID-19 Fear Scale and COVID-19 Hygiene Scale with Cronbach’s alpha coefficient of 88 and 91, respectively, were analysed by binary logistic regression. The mean age of 1,753 participants of the online survey was 31.60±14.79 (min=18-max=95) among them 1,753 (15.8%) reported to have had COVID-19 disease and 18.3% who were healthcare professionals were vaccinated against COVID-19. The dependent variable of the logistic regression model established for unvaccinated individuals was attitude for vaccination. Those who refused or were hesitant for vaccination consisted the risk group in the model. Among the independent variables included in the model, gender, educational level, age, changing hygiene behaviours, social distance and use of masks, shopping hygiene, and attention to hygienic behaviours when coming home from outside were found to be associated with dependent variable. The risk of vaccine hesitancy was found to be 1.4 times higher in women, 1.4 times higher in those with an education level below high school, and 2.2 times higher in people younger than 65 years of age (p<0.001). In this study, it was determined that the fear of COVID-19 disease was not effective in estimating vaccine hesitancy, whereas social distance and the use of masks and compliance to some hygiene behaviours were effective in estimating the risk of vaccine hesitancy.