Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study

COGENDEZ, EBRU; Beydilli Nacak, Gulay; ÖZKAYA, ENIS; Tozkır, Elif; Kaya, Fatih

doi:10.21613/GORM.2020.1034

Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study

Gülay BEYDİLLİ NACAK, (Sağlık Bilimleri Üniversitesi, Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Elif TOZKIR, (Sağlık Bilimleri Üniversitesi, Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Enis ÖZKAYA, (Sağlık Bilimleri Üniversitesi, Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Ebru ÇÖĞENDEZ, (Sağlık Bilimleri Üniversitesi, Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Fatih KAYA (Sağlık Bilimleri Üniversitesi, Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

4 0

Yıl: 2021 Cilt: 27 Sayı: 2 Sayfa Aralığı: 143 - 149 Metin Dili: İngilizce DOI: 10.21613/GORM.2020.1034 İndeks Tarihi: 04-02-2022

Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study

Öz:

OBJECTIVE: To compare some cycle characteristics and outcomes using a protocol consisting of a GnRH agonist trigger or hCG trigger after cotreatment with GnRH antagonist. STUDY DESIGN: Thirty-three patients under 35 years of age with polycystic ovarian syndrome, polycystic ovarian morphology, or previous high response who underwent ovulation trigger by GnRH agonist trigger and 132 patients under 35 years of age with the polycystic ovarian syndrome, polycystic ovarian morphology, or previous high response who underwent ovulation trigger by hCG for IVF treatment. Patients were non-randomly assigned to an ovarian stimulation protocol consisting of either GnRH agonist trigger after cotreatment with GnRH antagonist (study group) or hCG trigger after antagonist protocol (control group). RESULTS: The positive pregnancy test was obtained in 70 women in the control group whereas in 13 cases in the study group (p=0.161). No case in the study group needed hospitalization whereas there were 15 cases in the control group who were required to be hospitalized due to ovarian hyperstimulation related symptoms (p=0.04). CONCLUSIONS: The use of a protocol consisting of a GnRH agonist trigger after GnRH antagonist cotreatment and freeze-all strategy reduces the risk of ovarian hyperstimulation syndrome in high-risk patients undergoing IVF without affecting pregnancy rates.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Delvigne A, Rozenberg S. Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS). Hum Reprod Update. 2003;9(1):77-96. doi: 10.1093/ humupd/dmg005.
2. Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum Reprod Update. 2002;8(6):559-77. doi: 10.1093/ humupd/8.6.559.
3. Wada I, Matson PL, Troup SA, Lieberman BA. Assisted conception using buserelin and human menopausal gonadotrophins in women with polycystic ovary syndrome. Br J Obstet Gynaecol. 1993;100(4):365-9. doi: 10.1111/j. 1471-0528.1993.tb12981.x.
4. Delvigne A, Demoulin A, Smitz J, Donnez J, Koninckx P, Dhont M, et al. The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicentric study. I. Clinical and biological features. Hum Reprod. 1993;8(9): 1353-60. doi: 10.1093/oxfordjournals.humrep.a138260.
5. Itskovitz-Eldor J, Kol S, Mannaerts B. Use of a single bolus of GnRH agonist triptorelin to trigger ovulation after GnRH antagonist ganirelix treatment in women undergoing ovarian stimulation for assisted reproduction, with special reference to the prevention of ovarian hyperstimulation syndrome: preliminary report: short communication. Hum Reprod. 2000;15(9):1965-8. doi: 10.1093/ humrep/15.9.1965.
6. De Jong D, Van Hooren EG, Macklon NS, Mannaerts BM, Fauser BC. Pregnancy and birth after GnRH agonist treatment for induction of final oocyte maturation in a woman undergoing ovarian stimulation for ICSI, using a GnRH antagonist (Orgalutran/Antagon) to prevent a premature LH surge: a case report. J Assist Reprod Genet. 2001;18(1):30-3. doi: 10.1023/a:1026498629324.
7. Kol S. Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. Fertil Steril. 2004;81(1):1-5. doi: 10.1016/j.fertnstert.2003.05.032.
8. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25. doi: 10. 1016/j.fertnstert.2003.10.004.
9. Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003;9(6):505-14. doi: 10.1093/humupd/dmg044.
10. Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J In Vitro Fert Embryo Transf. 1986;3(5): 284-95. doi: 10.1007/BF01133388.
11. Mackens S, Santos-Ribeiro S, van de Vijver A, Racca A, Van Landuyt L, Tournaye H, et al. Frozen embryo transfer: a review on the optimal endometrial preparation and timing. Hum Reprod. 2017;32(11):2234-42. doi: 10.1093/ humrep/dex285.
12. Golan A, Ron-el R, Herman A, Soffer Y, Weinraub Z, Caspi E. Ovarian hyperstimulation syndrome: an update review. Obstet Gynecol Surv. 1989;44(6):430-40. doi: 10. 1097/00006254-198906000-00004.
13. Babayof R, Margalioth EJ, Huleihel M, Amash A, ZylberHaran E, Gal M, et al. Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial. Hum Reprod. 2006;21(5):1260-5. doi: 10.1093/humrep/dei475.
14. Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002;87(2):709-15. doi: 10.1210/jcem. 87.2.8197.
15. Beckers NG, Macklon NS, Eijkemans MJ, Ludwig M, Felberbaum RE, Diedrich K, et al. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab. 2003;88 (9):4186-92. doi: 10.1210/jc.2002-021953.
16. Lanzone A, Fulghesu AM, Apa R, Caruso A, Mancuso S. LH surge induction by GnRH agonist at the time of ovulation. Gynecol Endocrinol. 1989;3(3):213-20. doi: 10. 3109/09513598909152302.
17. Humaidan P, Bredkjaer HE, Bungum L, Grondahl ML, Westergaard L, Andersen CY. GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ ICSI cycles: a prospective randomized study. Hum Reprod. 2005;20(5):1213-20. doi: 10.1093/humrep/deh765.
18. Kolibianakis EM, Schultze-Mosgau A, Schroer A, van Steirteghem A, Devroey P, Diedrich K, et al. A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists. Hum Reprod. 2005;20(10):2887-92. doi: 10.1093/humrep/dei150.
19. Griesinger G, Diedrich K, Devroey P, Kolibianakis EM. GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysis. Hum Reprod Update. 2006;12(2):159-68. doi:10.1093/humupd/dmi045.
20. Le MT, Nguyen DN, Zolton J, Nguyen VQH, Truong QV, Cao NT, et al. GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial. Int J Endocrinol. 2019 Mar 13;2019:2487067. Doi: 10.1155/2019/2487067.eCollecti on 2019.
21. Zhu Q, Chen Q, Wang L, Lu X, Lyu Q, Wang Y, et al. Live birth rates in the first complete IVF cycle among 20 687 women using a freeze-all strategy. Hum Reprod. 2018;33(5):924-9. doi: 10.1093/humrep/dey044.
22. Ferraretti AP, Gianaroli L, Magli C, Fortini D, Selman HA, Feliciani E. Elective cryopreservation of all pronucleate embryos in women at risk of ovarian hyperstimulation syndrome: efficiency and safety. Hum Reprod. 1999;14 (6):1457-60. doi: 10.1093/humrep/14.6.1457.
23. Roque M, Lattes K, Serra S, Solà I, Geber S, Carreras R, et al. Fresh embryo transfer versus frozen embryo transfer in vitro fertilization cycles: a systematic review and metaanalysis. Fertil Steril. 2013;99(1):156-62. doi: 10.1016/j. fertnstert.2012.09.003.
24. Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, et al. Transfer of Fresh versus Frozen embryos in Ovulatory Women. N Engl J Med. 2018;378(2):126-36. doi: 10.10 56/NEJMoa1705334.
25. Vuong LN, Dang VQ, Ho TM, Huynh BG, Ha T, Pham TD, et al. IVF transfer of fresh or frozen embryos in women without polycystic ovaries. N Engl J Med. 2018; 378(2):137-47. doi: 10.1056/NEJMoa1703768.
26. Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375(6):523-33. doi: 10.1056/NEJMoa1513873.
27. Tomás C, Alsbjerg B, Martikainen H, Humaidan P. Pregnancy loss after frozen-embryo transfer-a comparison of three protocols. Fertil Steril. 2012;98(5):1165-9. doi: 10.1016/j.fertnstert.2012.07.1058.
28. Wennerholm UB, Henningsen AK, Romundstad LB, Bergh C, Pinborg A, Skjaerven R, et al. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod. 2013;28(9):2545-53. doi: 10.1093/humrep/ det272.
29. Krishna D, Dhoble S, Praneesh G, Rathore S, Upadhaya A, Rao K. Gonadotropin-releasing hormone agonist trigger is a better alternative than human chorionic gonadotropin in PCOS undergoing IVF cycles for an OHSS Free clinic: a randomized control trial. J Hum Reprod Sci. 2016;9(3):164-72. doi: 10.4103/0974-1208.192056.
30. Deepika K, Sindhuma D, Kiran B, Ravishankar N, Gautham P, Kamini R. Empty Follicle Syndrome Following GnRHa Trigger in PCOS Patients Undergoing IVF Cycles. J Reprod Infertil. 2018;19(1):16-25. PMID: 29850443. PMID: 29850443.
31. Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S. Ovarian hyperstimulation syndrome preven-tion by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a "freeze-all" strategy: a prospective multicentric study. Fertil Steril. 2011;95(6):2029-33. doi: 10.1016/j.fertnstert. 2011.01.163.
32. Fatemi HM, Popovic-Todorovic B, Humaidan P, Kol S, Banker M, Devroey P. Severe ovarian hyperstimulation syndrome after gonadotropin-releasing hormone (GnRH) agonist trigger and "freeze-all" approach in GnRH antagonist protocol. Fertil Steril. 2014;101(4):1008-11. doi: 10. 1016/j.fertnstert.2014.01.019.
33. Rahav Koren R, Gonen O, Hershko Klement A, Haikin Herzberger E, Ghetler Y, Shulman A, et al. Number of oocytes retrieved as a criterion for "freeze-all" strategy versus a single "rescue" bolus of low-dose human chorionic gonadotropin following GnRH agonist for ovulation triggering: a pilot study. Gynecol Obstet Invest. 2018; 83(5):471-76. doi: 10.1159/000479557.
34. Hwang JL, Chen SU, Chen HJ, Chen HF, Yang YS, Chang CH, et al. Feasibility of corifollitropin alfa/GnRH antagonist protocol combined with GnRH agonist triggering and freeze-all strategy in polycystic ovary syndrome patients. J Formos Med Assoc. 2018;117(6):535-40. doi: 10.1016/ j.jfma.2017.05.009.
35. Stormlund S, Løssl K, Zedeler A, Bogstad J, Prætorius L, Nielsen HS, et al. Comparison of a 'freeze-all' strategy including GnRH agonist trigger versus a 'fresh transfer' strategy including hCG trigger in assisted reproductive technology (ART): a study protocol for a randomised controlled trial. BMJ Open. 2017;7(7):e016106. doi: 10. 1136/bmjopen-2017-016106.

APA	Beydilli Nacak G, Tozkır E, ÖZKAYA E, COGENDEZ E, Kaya F (2021). Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. , 143 - 149. 10.21613/GORM.2020.1034
Chicago	Beydilli Nacak Gulay,Tozkır Elif,ÖZKAYA ENIS,COGENDEZ EBRU,Kaya Fatih Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. (2021): 143 - 149. 10.21613/GORM.2020.1034
MLA	Beydilli Nacak Gulay,Tozkır Elif,ÖZKAYA ENIS,COGENDEZ EBRU,Kaya Fatih Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. , 2021, ss.143 - 149. 10.21613/GORM.2020.1034
AMA	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. . 2021; 143 - 149. 10.21613/GORM.2020.1034
Vancouver	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. . 2021; 143 - 149. 10.21613/GORM.2020.1034
IEEE	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F "Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study." , ss.143 - 149, 2021. 10.21613/GORM.2020.1034
ISNAD	Beydilli Nacak, Gulay vd. "Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study". (2021), 143-149. https://doi.org/10.21613/GORM.2020.1034

APA	Beydilli Nacak G, Tozkır E, ÖZKAYA E, COGENDEZ E, Kaya F (2021). Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. GORM:Gynecology Obstetrics & Reproductive Medicine, 27(2), 143 - 149. 10.21613/GORM.2020.1034
Chicago	Beydilli Nacak Gulay,Tozkır Elif,ÖZKAYA ENIS,COGENDEZ EBRU,Kaya Fatih Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. GORM:Gynecology Obstetrics & Reproductive Medicine 27, no.2 (2021): 143 - 149. 10.21613/GORM.2020.1034
MLA	Beydilli Nacak Gulay,Tozkır Elif,ÖZKAYA ENIS,COGENDEZ EBRU,Kaya Fatih Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.27, no.2, 2021, ss.143 - 149. 10.21613/GORM.2020.1034
AMA	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(2): 143 - 149. 10.21613/GORM.2020.1034
Vancouver	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study. GORM:Gynecology Obstetrics & Reproductive Medicine. 2021; 27(2): 143 - 149. 10.21613/GORM.2020.1034
IEEE	Beydilli Nacak G,Tozkır E,ÖZKAYA E,COGENDEZ E,Kaya F "Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study." GORM:Gynecology Obstetrics & Reproductive Medicine, 27, ss.143 - 149, 2021. 10.21613/GORM.2020.1034
ISNAD	Beydilli Nacak, Gulay vd. "Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce Oocyte Maturation in Assisted Reproductive Technology Cycles: A Retrospective Cohort Study". GORM:Gynecology Obstetrics & Reproductive Medicine 27/2 (2021), 143-149. https://doi.org/10.21613/GORM.2020.1034