Yıl: 2019 Cilt: 11 Sayı: Ek 1 Sayfa Aralığı: 276 - 292 Metin Dili: Türkçe DOI: 10.18863/pgy.628562 İndeks Tarihi: 24-01-2022

Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi

Öz:
Bu çalışmanın amacı çocuklarda astım şiddeti il”e depresyon, açık kaygı, yaşam kalitesi, somatizasyon gibi değişkenleri ve astımda bağışıklık sistemi belirleyicilerinden olan IgE düzeyi arasındaki olası ilişkiyi analiz etmektir. Toplamda 141 katılımcının bulunduğu bu çalışmanın örneklemini 6-12 yaş arası astımlı çocuklar oluşturmaktadır. Katılımcıların ruh sağlığı belirtilerini değerlendirmek adına Çocuk Depresyon Ölçeği, Çocuklar İçin Açık Kaygı Ölçeği, Pediatrik Astımda Yaşam Kalitesi Ölçeği ve Davranış Değerlendirme Ölçeğinin Somatik Yakınmalar Alt Ölçeği kullanılmıştır. Astım şiddeti, astım kontrol düzeyi üzerinden uzman hekimlerce değerlendirilirken, Serum IgE düzeyleri ELISA tekniği kullanılarak elde edilmiştir. Kontrolsüz astım grubunda bulunan katılımcıların açık kaygı puanlarıyla IgE düzeyleri arasında orta düzeyde anlamlı yüksek korelasyon olduğu görülmüştür. Araştırma verileri değerlendirildiğinde, ruh sağlığı değişkenlerinden açık kaygı ile astımda bağışıklık sistemi belirleyicilerinden olan IgE düzeyi arasındaki ilişkinin, astım hastalığının şiddeti üzerinde etkili olabileceği yönünde veriler elde edildiğinden, gelecek araştırmaların söz konusu ilişkiyi psikonöroimmunolojik açıdan derinlemesine incelemesi önerilmektedir.
Anahtar Kelime:

Relationship Between Serum IgE Level and Anxiety, Depression, Somatization and Quality of Life in Pediatric Asthma

Öz:
The main purpose of the current study is to explore the potential relationship of asthma with depression, somatic predisposition, quality of life, manifest anxiety and Serum levels of IgE level. 141 participants between 6 and 12 years old were recruited and the following scales were used: Child Depression Inventory, Revised Version of Child Manifest Anxiety Scale, Pediatric Asthma Quality of Life Questionnaire and the Somatic Complaints Subscale of Child Behavior Check List. Based on asthma control level, severity of asthma was assessed by the specialists and the serum levels of IgE were assessed by using ELISA technique. The results indicated that there was a highly correlated relationship between serum levels of IgE and manifest anxiety levels among uncontrolled asthma group. These results suggested that, since the strong correlational relationship between the serum levels of IgE and manifest anxiety would have an effect on asthma control, future research should focus on this relationship from the aspect of psychoneuroimmunology.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Achenbach TM, Dumenci L, Rescorla LA (2002) Ten-year comparisons of problems and competencies for national samples of youth: self, parent, and teacher reports. J Emot Behav Disord, 10:194-203.
  • Ader N, Kohen N, Felten D (1995) Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet, 345:99-103.
  • Adeyeye OO, Adewumi TA, Adewuya AO (2017) Effect of psychological and other factors on quality of life amongst asthma outpatients in Lagos, Nigeria. Respir Med, 122:67-70.
  • Akcakaya N, Aydogan M, Hassanzadeh A, Camcioglu Y, Cokugras H (2003) Psychological problems in Turkish asthmatic children and their families. Allergol Immunopathol, 31:282-287.
  • Aktan ZD (2016) Reliability and validity of pediatric asthma quality of life questionnaire for 6 children aged 6 years old- PAQLQ (2006) 7. Çocukluk Bizde Kalsın Kongresi, 5-7 Mayıs 2016 Çanakkale, Türkiye. Kongre Özet Kitabı sayfa:6.
  • Barnes PJ (1999) Novel approaches and targets for treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 160:72–79.
  • Barnett D, Walker B, Landay A, Denny TN (2008) CD4 immunophenotyping in HIV infection. Nat Rev Microbiol, 6(suppl 11):S7– S15.
  • Baron RB, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol, 51:1173-1182.
  • Blaiss MS (2005) Asthma disease management: a critical analysis. Ann Allergy Asthma Immunol, 95(suppl 1):S10-S16.
  • Boran P, Tokuç G, Pişgin B, Öktem S. (2008) Assessment of quality of life in asthmatic Turkish children. Turk J Pediatr, 50:18-22.
  • Borish L (2016) The immunology of asthma phenotypes and their implications for personalized treatment. Ann Allergy Asthma Immunol, 117:108-114.
  • Bozo Ö (2007). Psikonöroimmünoloji. Kriz Dergisi, 15(3):21-30.
  • Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med, 320:271–277.
  • Çevik Ü (2011). The effect on the self-efficacy and the prognosis of disease of the given training for the children and adolescents who have asthma. (Uzmanlık tezi). Erzurum, Atatürk Üniversitesi.
  • Chrousos GP, Gold PW (1992) the concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA, 267:1244-52.
  • Coban H, Ediger D (2018) Control of asthma, quality of life, anxiety and depression symptoms among Turkish patients with asthma. Electronic Journal of General Medicine,15(5):em71.
  • Cohen S, Herbert TB (1996) Health psychology: psychological factors and physical disease from the perspective of human psychoneuroimmunology. Annu Rev Psychol, 47:113-42.
  • Çölümlü GM (2014) The psychometric properties of the revised children’s manifest anxiety scale. (Uzmanlık tezi). İstanbul, Bahçeşehir Üniversitesi.
  • Crepaz N, Passin WF, Herbst JH, Rama SM, Malow RM, Purcell DW et al (2008) HIV/AIDS Prevention research synthesis (prs) team; meta-analysis of cognitive-behavioral interventions on HIV-positive persons' mental health and immune functioning. Health Psychol, 27:4-14.
  • Demirci E (2011). Astımlı çocuklarda yaşam kalitesi ve etkileyen bazı faktörler. (Uzmanlık tezi). Sivas, Cumhuriyet Üniversitesi.
  • Di Marco F, Verga M, Santus P, Giovannelli F, Busatto P, Neri M et al. (2010). Close correlation between anxiety, depression, and asthma control. Respir Med,104:22-28.
  • Erol N, Şimşek Z (2010) The Turkish version of child behavior check list manual (CBCL, YSR, TRF). Ankara, Metis.
  • Global Initiative for Asthma (GINA) (2006) http://www.ginasthma.org (10 Ocak 2016’da ulaşıldı)
  • Goodwin, RD, Robinson M, Sly PD, McKeague IW, Susser ES, Zubrick SR et al. (2013) Severity and persistence of asthma and mental health: a birth cohort study. Psychol Med, 43:1313-1322.
  • Gregory AM, Caspi A, Moffitt TE, Milne BJ, Poulton R, Sears MR (2009) Links between anxiety and allergies: psychobiological reality or possible methodological bias. J Pers, 77:347–362.
  • Hossny E, Caraballo L, Casale T, El-Gamal Y, Rosenwasser L (2017) Severe asthma and quality of life. World Allergy Organ J, 10:28.
  • Ironson G, O'Cleirigh C, Fletcher MA, Laurenceau J, Balbin E, Klimaset N al. (2005) Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med, 67:1013–1021.
  • Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M (1996) Measuring quality of life in children with asthma. Qual Life Res, 5:35-46.
  • Kapfhammer HP (2006) Somatic symptoms in depression. Dialogues Clin Neurosci, 8:227–239.
  • Kartaloğlu, Z (2011) Astım ve stres arasındaki ilişkiler. Gülhane Tıp Derg, 53:304-312.
  • Katon W, Kleinman A, Rosen G (1982) Depression and somatization: a review. Part I. Am J Med, 72:127-35.
  • Klinnert MD, Kaugars AS, Strand M, Silveira L (2008) Family psychological factors in relation to children's asthma status and behavioral adjustment at age 4. Fam Process, 47:41-61.
  • Kotrotsiou E, Krommydas G, Papathanasiou I, Kotrotsiou S, Paralikas T, Lahana Eet al. (2011) Anxiety and depression in teenagers and young adults with asthma. Health Science Journal, 5:229-236.
  • Kovacs M (1981) Rating scales to assess depression in schools age children. Acta Paedopsychiatr, 46:305-315.
  • Lama M, Chatterjee M, Chaudhuri TK (2013) Total serum immunoglobulin E in children with asthma. Indian J Clin Biochem,. 28:197–200.
  • Lambrecht BN, Hammad H (2015) The immunology of asthma. Nat Immunol, 16:45-56.
  • Lavoie KL, Cartier A, Labrecque M, Bacon SL, Lemière C, Malo JL et.al. (2005) Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? Respir Med, 99:1249-1257.
  • Leonard BE (2010) The concept of depression as a dysfunction of the immune system. Curr Immunol Rev, 6:205–212.
  • Lupinek C, Derfler K, Lee S, et al. (2017) Extracorporeal IgE immunoadsorption in allergic asthma: safety and efficacy. E Bio Medicine, 17:119–133.
  • Malone C, Wachholtz A (2018) The relationship of anxiety and depression to subjective well-being in a mainland Chinese sample. J Relig Health, 57:266–278.
  • Mancuso CA, Rincon M, Mcculloch CE and Charlson ME (2001) Self-efficacy, depressive symptoms, and patients’ expectation predict outcomes in asthma. Med Care, 39:1326-1338.
  • McDonald PG, O’Connell M, Lutgendorf SK (2013) Psychoneuroimmunology and cancer: A decade of discovery, paradigm shifts, and methodological innovations. Brain Behav Imm, 30(Suppl):S1-S9.
  • Murali R, Hanson MD, Chen E (2006) Psychological stress and its relationship to cytokines and inflammatory diseases. In Cytokines: Stress and Immunity. (Eds NP Plotnikoff, RE Faith, AJ Murgo, RA Good):29-51. Florida,CRC Press.
  • Olff M (1999) Stress, depression and immunity: the role of defense and coping styles. Psychiatry Res, 85:7-15.
  • Opolski M, Wilson I (2005) Asthma and depression: a pragmatic review of the literature and recommendations for future research. Clin Pract Epidemiol Ment Health, 1:18.
  • Öy B (1991) Child Depression Inventory: The Turkish reliability and validity study. TurkPsikiyatri Derg, 2:132-136.
  • Potoczek A, Nizankowska-Mogilnicka E, Bochenek G, Szczeklik A (2006) Links between panic disorder, depression, defense mechanisms, coherence and family functioning in patients suffering from severe asthma. Psychiatry Res, 85:7-15.
  • Revenson TA, and Hoyt MA (2016) Chronic illness and mental health. In Encyclopedia of Mental Health, 2nd ed. (Eds HS. Friedman):284-292. Boston, MA, Academic Press.
  • Reynolds CR, Richmond BO (1978) What I think and feel: A revised measure of children’s manifest anxiety. J Abnorm Child Psychol, 6:271-80.
  • Rimington LD, Davies DH, Lowe D, Pearson MG (2001) Relationship between anxiety, depression, and morbidity in adult asthma patients. Thorax, 56:266-271.
  • Rogala B, Bozek A, Gluck J, Jarzab J (2015) Prevalence of IgE-mediated allergy and evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial asthma. Postepy Dermatol Alergol, 32:274–280.
  • Rotsides DZ, Goldstein IF, Canfield SM, Perzanowski M, Mellins RB, Hoepner L et al. (2010) Asthma, allergy, and IgE levels in NYC head start children. Respir Med, 104:345–355.
  • Saggini A, Maccauro G, Tripodi D, De Lutiis MA, Conti F, Felaco P et al. (2011). Allergic inflammation: role of cytokines with special emphasis on IL-4. Int J Immunopathol Pharmacol, 24:305-311.
  • Sandeep T, Roopakala MR, Silvia CRWD, Chandrashekara S, Rao M (2010). Evaluation of serum immunoglobulin E levels in bronchial asthma. Lung India, 27:138–140.
  • Sears MR, Burrows B, Flannery EM et al. (1991). Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med, 325:1067–1071.
  • Segerstrom SC, Miller GE (2004) Psychological stress and the human immune system: a meta- analytic study of 30 years of inquiry. Psychol Bull, 130:601-630.
  • Steinke JW, Borish L (2001) Th2 cytokines and asthma - Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res, 2:66–70.
  • Tanaka A, Jinno M, Hirai K, Miyata Y, Mizuma H, Yamaguchi M et al. (2014) Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control. Respir Res, 15:144.
  • Thoren CT, Petermann F (2000) Reviewing asthma and anxiety, Respir Med, 94:409-415.
  • Thornton LM, Andersen BL (2006) Psychoneuroimmunology examined: The role of subjective stress. Cellscience, 2(4):66-91.
  • Yüksel H, Yilmaz O, Kirmaz C, Eser E (2009) Validity and reliability of the Turkish translation of the Pediatric Asthma Quality of Life Questionnaire.Turk J Pediatr, 51:154-160.
APA Aktan Z, Sertel Berk Ö, Erdoğan F, OKTEM S (2019). Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. , 276 - 292. 10.18863/pgy.628562
Chicago Aktan Z. Deniz,Sertel Berk Özlem,Erdoğan Fırat,OKTEM SEDAT Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. (2019): 276 - 292. 10.18863/pgy.628562
MLA Aktan Z. Deniz,Sertel Berk Özlem,Erdoğan Fırat,OKTEM SEDAT Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. , 2019, ss.276 - 292. 10.18863/pgy.628562
AMA Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. . 2019; 276 - 292. 10.18863/pgy.628562
Vancouver Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. . 2019; 276 - 292. 10.18863/pgy.628562
IEEE Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S "Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi." , ss.276 - 292, 2019. 10.18863/pgy.628562
ISNAD Aktan, Z. Deniz vd. "Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi". (2019), 276-292. https://doi.org/10.18863/pgy.628562
APA Aktan Z, Sertel Berk Ö, Erdoğan F, OKTEM S (2019). Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. Psikiyatride Güncel Yaklaşımlar, 11(Ek 1), 276 - 292. 10.18863/pgy.628562
Chicago Aktan Z. Deniz,Sertel Berk Özlem,Erdoğan Fırat,OKTEM SEDAT Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. Psikiyatride Güncel Yaklaşımlar 11, no.Ek 1 (2019): 276 - 292. 10.18863/pgy.628562
MLA Aktan Z. Deniz,Sertel Berk Özlem,Erdoğan Fırat,OKTEM SEDAT Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. Psikiyatride Güncel Yaklaşımlar, vol.11, no.Ek 1, 2019, ss.276 - 292. 10.18863/pgy.628562
AMA Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. Psikiyatride Güncel Yaklaşımlar. 2019; 11(Ek 1): 276 - 292. 10.18863/pgy.628562
Vancouver Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi. Psikiyatride Güncel Yaklaşımlar. 2019; 11(Ek 1): 276 - 292. 10.18863/pgy.628562
IEEE Aktan Z,Sertel Berk Ö,Erdoğan F,OKTEM S "Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi." Psikiyatride Güncel Yaklaşımlar, 11, ss.276 - 292, 2019. 10.18863/pgy.628562
ISNAD Aktan, Z. Deniz vd. "Pediatrik Astımda Kaygı, Depresyon, Somatizasyon veYaşam Kalitesi ile Serum IgE Düzeyi İlişkisi". Psikiyatride Güncel Yaklaşımlar 11/Ek 1 (2019), 276-292. https://doi.org/10.18863/pgy.628562