RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress

SÖNMEZER, Meliha Çağla; Unal, Serhat; Rudvan Al, Leyla Ipek

doi:10.3906/sag-2104-139

RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress

Leyla İpek RUDVAN AL, (Hacettepe Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Meliha Çağla SÖNMEZER, (Hacettepe Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Serhat ÜNAL (Hacettepe Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2021 Cilt: 51 Sayı: Özel Sayı 1 Sayfa Aralığı: 3246 - 3252 Metin Dili: İngilizce DOI: 10.3906/sag-2104-139 İndeks Tarihi: 26-01-2022

RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress

Öz:

Abstract: Due to the COVID-19 infection, which was recognized as a global pandemic by the WHO on March 11, 2020, the number of cases and disease-related deaths increases day by day globally. For this reason, antiviral agents used in treatment and vaccines, the most effective weapon in prevention, continue to be the most popular topic of the plan. Several situations are expected to affect the course of the pandemic. The loss of the ability of the virus to mutate and cause disease, the fact that those who become immunized by having the disease in the society reach a critical rate and create social immunity (herd immunity), and the provision of social immunity with effective vaccination can be counted as some of these situations. Candidate vaccines in the clinical phase among RNA-based vaccines: This review aimed to examine COVID-19 vaccine candidates using RNA technology and compile its current data. We used PubMed, Google Scholar, and World Health Organization (WHO) databases. Also, we followed up on the latest news and developments on vaccine companies’ websites. Conclusion: Vaccination trials, which started due to the seriousness and urgency of the situation that we are in, continue exceptionally quickly and effectively. As per the WHO›s data on July 9, 2021, there have been 291 vaccine trials, 107 of which are in the clinical phase, and 18 (16%) of the vaccine candidates in the clinical phase are RNA-based vaccines. Also, the number of RNA-based vaccines with ongoing preclinical trials is 2Key words: SARS-CoV2, COVID-19, vaccine trials, m-RNA

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Rudvan Al L, SÖNMEZER M, Unal S (2021). RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. , 3246 - 3252. 10.3906/sag-2104-139
Chicago	Rudvan Al Leyla Ipek,SÖNMEZER Meliha Çağla,Unal Serhat RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. (2021): 3246 - 3252. 10.3906/sag-2104-139
MLA	Rudvan Al Leyla Ipek,SÖNMEZER Meliha Çağla,Unal Serhat RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. , 2021, ss.3246 - 3252. 10.3906/sag-2104-139
AMA	Rudvan Al L,SÖNMEZER M,Unal S RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. . 2021; 3246 - 3252. 10.3906/sag-2104-139
Vancouver	Rudvan Al L,SÖNMEZER M,Unal S RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. . 2021; 3246 - 3252. 10.3906/sag-2104-139
IEEE	Rudvan Al L,SÖNMEZER M,Unal S "RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress." , ss.3246 - 3252, 2021. 10.3906/sag-2104-139
ISNAD	Rudvan Al, Leyla Ipek vd. "RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress". (2021), 3246-3252. https://doi.org/10.3906/sag-2104-139

APA	Rudvan Al L, SÖNMEZER M, Unal S (2021). RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. Turkish Journal of Medical Sciences, 51(Özel Sayı 1), 3246 - 3252. 10.3906/sag-2104-139
Chicago	Rudvan Al Leyla Ipek,SÖNMEZER Meliha Çağla,Unal Serhat RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. Turkish Journal of Medical Sciences 51, no.Özel Sayı 1 (2021): 3246 - 3252. 10.3906/sag-2104-139
MLA	Rudvan Al Leyla Ipek,SÖNMEZER Meliha Çağla,Unal Serhat RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. Turkish Journal of Medical Sciences, vol.51, no.Özel Sayı 1, 2021, ss.3246 - 3252. 10.3906/sag-2104-139
AMA	Rudvan Al L,SÖNMEZER M,Unal S RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. Turkish Journal of Medical Sciences. 2021; 51(Özel Sayı 1): 3246 - 3252. 10.3906/sag-2104-139
Vancouver	Rudvan Al L,SÖNMEZER M,Unal S RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress. Turkish Journal of Medical Sciences. 2021; 51(Özel Sayı 1): 3246 - 3252. 10.3906/sag-2104-139
IEEE	Rudvan Al L,SÖNMEZER M,Unal S "RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress." Turkish Journal of Medical Sciences, 51, ss.3246 - 3252, 2021. 10.3906/sag-2104-139
ISNAD	Rudvan Al, Leyla Ipek vd. "RNA-Based COVID-19 vaccine candidates with clinical phase trials in progress". Turkish Journal of Medical Sciences 51/Özel Sayı 1 (2021), 3246-3252. https://doi.org/10.3906/sag-2104-139