Yıl: 2021 Cilt: 51 Sayı: Özel Sayı 1 Sayfa Aralığı: 3312 - 3326 Metin Dili: İngilizce DOI: 10.3906/sag-2106-134 İndeks Tarihi: 26-01-2022

Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

Öz:
Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized by significant changes in cardiovascular, respiratory, endocrine, and immunological systems, there are concerns on issues like the course of disease in pregnant women, safety of medications, route of delivery and risk of obstetric complications. The aim of this review is to summarize the current literature in the management of pregnant women during the COVID-19 pandemic. Although more than 90% of pregnant women with COVID-19 recover without serious morbidity, rapid deterioration of disease and higher rates of obstetric complications may be observed. The risk of vertical transmission has not been clearly revealed yet. Decreasing the number of prenatal visits, shortening the time allocated for the examinations, active use of telemedicine services, limiting the number of persons in healthcare settings, combining prenatal tests in the same visit, restricting visitors during the visits, providing a safe environment in healthcare facilities, strict hygiene control, and providing personal protective equipment during the visits are the main strategies to control the spread of disease according to current guidelines. Although new medication alternatives are being proposed every day for the treatment of COVID-19, our knowledge about the use of most of these drugs in pregnancy is limited. Preliminary results are promising for the administration of SARS-CoV-2 vaccines in the pregnant population. Timing of delivery should be decided based on maternal health condition, accompanying obstetric complications and gestational age. Cesarean delivery should be performed for obstetric indications. Breast feeding should be encouraged as long as necessary precautions for viral transmission are taken. In conclusion, an individualized approach should be provided by a multidisciplinary team for the management of pregnant women with COVID-19 to achieve favorable outcomes.Key words: COVID-19, obstetric complications, pregnancy, SARS-CoV-2, vaccines
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Pollard CA, Morran MP, Nestor-Kalinoski AL. The COVID-19 pandemic: a global health crisis. Physiological Genomics. 2020;52(11):549-557.https://doi.org/10.1152/ physiolgenomics.00089.2020
  • 2. Hellewell J, Abbott S, Gimma A, Bosse NI, Jarvis CI et al. Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. The Lancet Global Health. 2020;8(4):e488-e496. https://doi.org/10.1016/S2214- 109X(20)30074-7
  • 3. Lancet T. COVID-19: protecting health-care workers. Lancet. 2020;395(10228):922. https://doi.org/10.1016/S0140- 6736(20)30644-9
  • 4. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. American journal of obstetrics and gynecology. 2020;222(5):415-426. https://doi.org/10.1016/j. ajog.2020.02.017
  • 5. Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review. The Journal of Maternal-Fetal & Neonatal Medicine. 2020:1-4. https://doi. org/10.1080/14767058.2020.1759541
  • 6. Platto S, Wang Y, Zhou J, Carafoli E. History of the COVID-19 pandemic: origin, explosion, worldwide spreading. Biochemical and biophysical research communications. 2021;538:14-23. https://doi.org/10.1016/j.bbrc.2020.10.087
  • 7. Shang J, Ye G, Shi K, Wan Y, Luo C et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020;581(7807):221-224. https://doi.org/10.1038/s41586-020- 2179-y
  • 8. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e278. https://doi. org/10.1016/j.cell.2020.02.052
  • 9. Wang P, Nair MS, Liu L, Iketani S, Luo Y et al. Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7. Nature. 2021:1-6. https://doi.org/10.1038/s41586-021-03398-2
  • 10. Fontanet A, Autran B, Lina B, Kieny MP, Karim SSA et al. SARS-CoV-2 variants and ending the COVID-19 pandemic. The Lancet. 2021;397(10278):952-954. https://doi.org/10.1016/ S0140-6736(21)00370-6
  • 11. Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Annals of Internal Medicine. 2021;174(1):69-79. https://doi.org/10.7326/M20-5008
  • 12. Prather KA, Wang CC, Schooley RT. Reducing transmission of SARS-CoV-2. Science. 2020;368(6498):1422-1424. DOI: 10.1126/ science.abc6197
  • 13. Cheng HY, Jian SW, Liu DP, Ng TC, Huang WT et al. Contact Tracing Assessment of COVID-19 Transmission Dynamics in Taiwan and Risk at Different Exposure Periods Before and After Symptom Onset. JAMA Internal Medicine. 2020;180(9):1156- 1163. doi:10.1001/jamainternmed.2020.2020
  • 14. Sun K, Wang W, Gao L, Wang Y, Luo K et al. Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2. Science. 2021;371(6526). DOI: 10.1126/science.abe2424
  • 15. Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clinica Chimica Acta. 2020. https://doi.org/10.1016/j.cca.2020.05.044
  • 16. Theorell T. COVID-19 and working conditions in health care. Psychotherapy and psychosomatics. 2020:1. https://doi.org/ 10.1159/000507765
  • 17. Lurie N, Saville M, Hatchett R, Halton J. Developing Covid-19 vaccines at pandemic speed. New England journal of medicine. 2020;382(21):1969-1973. DOI: 10.1056/NEJMp2005630
  • 18. Lee SH, Son H, Peck KR. Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in longterm care hospitals? International journal of antimicrobial agents. 2020;55(6): https://doi.org/10.1016/j.ijantimicag.2020.105988
  • 19. Norwood OT. Male pattern baldness: classification and incidence. Southern medical journal. 1975;68(11):1359-1365. https://doi. org/ 10.1097/00007611-197511000-00009
  • 20. Qiao J. What are the risks of COVID-19 infection in pregnant women? The Lancet. 2020;395(10226):760-762. https://doi. org/10.1016/S0140-6736(20)30365-2
  • 21. Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. Mortality and Morbidity Weekly Report. 2020;69(44):1641-1647. doi:10.15585/mmwr.mm6925a1
  • 22. Sahin D, Tanacan A, Erol SA, Anuk AT, Eyi EGY et al. A pandemic center’s experience of managing pregnant women with COVID-19 infection in Turkey: A prospective cohort study. International Journal of Gynaecology and Obstetrics. 2020;151(1):74-82. https://doi.org/10.1002/ijgo.13318
  • 23. Sahin D, Tanacan A, Erol SA, Anuk AT, Yetiskin FDY et al. Updated experience of a tertiary pandemic center on 533 pregnant women with COVID-19 infection: A prospective cohort study from Turkey. International Journal of Gynaecology and Obstetrics. 2021;152(3):328-334. https://doi.org/10.1002/ijgo.13460
  • 24. Tanacan A, Erol SA, Turgay B, Anuk AT, Secen EI et al. The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey. European Journal of Obstetrics Gynecology and Reproductive Biology. 2020;253:31-34. https://doi. org/10.1016/j.ejogrb.2020.07.051
  • 25. Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. British Medical Journal. 2020;370:m3320 https://doi.org/10.1136/bmj.m3320.
  • 26. Yanes-Lane M, Winters N, Fregonese F, Bastos M, Perlman-Arrow S et al. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis. PloS one. 2020;15(11):e0241536. https://doi.org/10.1371/journal.pone.0241536
  • 27. Oshay RR, Chen MYC, Fields BKK, Demirjian NL, Lee RS et al. COVID-19 in pregnancy: a systematic review of chest CT findings and associated clinical features in 427 patients. Clinical Imaging. 2021;75:75-82. https://doi.org/10.1016/j. clinimag.2021.01.004
  • 28. Brent RL. The effect of embryonic and fetal exposure to x-ray, microwaves, and ultrasound: counseling the pregnant and nonpregnant patient about these risks. Seminars in Oncology. PMID: 2678486 1989;16(5):347-368
  • 29. Peng Q-Y, Wang X-T, Zhang L-N, Group CCCUS. Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic. Intensive Care Medicine. 2020:1. https://doi.org/10.1007/s00134-020-05996-6
  • 30. Song, Y., Zhang, M., Yin, L., Wang, K., Zhou, Y., Zhou, M., & Lu, Y. (2020). COVID-19 treatment: close to a cure?–a rapid review of pharmacotherapies for the novel coronavirus. International journal of antimicrobial agents. https://doi.org/10.1016/j. ijantimicag.2020.106080
  • 31. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Jama. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648
  • 32. Badr DA, Mattern J, Carlin A, Cordier AG, Maillart E et al. Are clinical outcomes worse for pregnant women at ≥20 weeks’ gestation infected with coronavirus disease 2019? A multicenter case-control study with propensity score matching. American Journal of Obstetrics and Gynecology. 2020;223(5):764-768. https://doi.org/10.1016/j.ajog.2020.07.045
  • 33. DeBolt CA, Bianco A, Limaye MA, Silverstein J, Penfield CA et al. Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls. American Journal of Obstetrics and Gynecology. 2021;224(5):510.e511-510.e512. https://doi. org/10.1016/j.ajog.2020.11.022
  • 34. Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. American Journal of Obstetrics and Gynecology. 2021. https://doi.org/10.1016/j.ajog.2021.05.016
  • 35. Martinez-Portilla RJ, Sotiriadis A, Chatzakis C, Torres-Torres J, Espino YSS et al. Pregnant women with SARS-CoV-2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx). Ultrasound in Obstetrics and Gynecology. 2021;57(2):224-231. https://doi.org/10.1002/uog.23575
  • 36. Kotlyar A, Grechukhina O, Chen A, Popkhadze S, Grimshaw A et al. Vertical Transmission of COVID-19: A Systematic Review and Meta-analysis. American Journal of Obstetrics and Gynecology. 2020. https://doi.org/10.1016/j.ajog.2020.07.049
  • 37. Edlow AG, Li JZ, Collier AY, Atyeo C, James KE et al. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Network Open. 2020;3(12):e2030455. doi:10.1001/ jamanetworkopen.2020.30455
  • 38. Pique-Regi R, Romero R, Tarca AL, Luca F, Xu Y et al. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? Elife Sciences. 2020;9
  • 39. Hosier H, Farhadian SF, Morotti RA, Deshmukh U, LuCulligan A et al. SARS–CoV-2 infection of the placenta. The Journal of Clinical Investigation. 2020;130(9). doi: 10.1172/ JCI139569
  • 40. Halici-Ozturk F, Ocal FD, Aydin S, Tanacan A, Ayhan SG et al. Investigating the risk of maternal-fetal transmission of SARSCoV-2 in early pregnancy. Placenta. 2021;106:25-29. https:// doi.org/10.1016/j.placenta.2021.02.006
  • 41. Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A. Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstetrica Gynecologica Scandinavica. 2020;99(5):565-568. doi: 10.1111/aogs.13870
  • 42. Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, Abbasi H, Mirjalili SR et al. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: a review. Fetal and Pediatric Pathology. 2020;39(3):246-250. https://doi.org/10.1080/15513815.2020.1747120
  • 43. Huntley BJF, Mulder IA, Di Mascio D, Vintzileos WS, Vintzileos AM et al. Adverse Pregnancy Outcomes Among Individuals With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review and Metaanalysis. Obstetrics and Gynecology. 2021;137(4):585-596. doi: 10.1097/AOG.0000000000004320
  • 44. Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. Canadian Medical Association Journal. 2021;193(16):E540-e548. https://doi.org/10.1503/cmaj.202604
  • 45. Elsaddig M, Khalil A. Effects of the COVID pandemic on pregnancy outcomes. Best Practice & Research Clinical Obstetrics & Gynaecology.73:125-136 2021. https://doi. org/10.1016/j.bpobgyn.2021.03.004
  • 46. Norman M, Navér L, Söderling J, Ahlberg M, Hervius Askling H et al. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA.2021;325(20):2076-2086 doi:10.1001/jama.2021.5775
  • 47. Ko JY, DeSisto CL, Simeone RM, Ellington S, Galang RR et al. Adverse pregnancy outcomes, maternal complications, and severe illness among U.S. delivery hospitalizations with and without a COVID-19 diagnosis. Clinical Infectious Diseases. 2021. https://doi.org/10.1093/cid/ciab344
  • 48. Jering KS, Claggett BL, Cunningham JW, Rosenthal N, Vardeny O et al. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. 2021;181(5):714-717. doi:10.1001/jamainternmed.2020.9241
  • 49. Rotshenker-Olshinka K, Volodarsky-Perel A, Steiner N, Rubenfeld E, Dahan MH. COVID-19 pandemic effect on early pregnancy: are miscarriage rates altered, in asymptomatic women? Archives Gynecology and Obstetrics. 2021;303(3):839- 845. https://doi.org/10.1007/s00404-020-05848-0
  • 50. la Cour Freiesleben N, Egerup P, Hviid KVR, Severinsen ER, Kolte AM et al. SARS-CoV-2 in first trimester pregnancy: a cohort study. Human Reproduction. 2021;36(1):40-47. https:// doi.org/10.1093/humrep/deaa311
  • 51. Cosma S, Carosso AR, Cusato J, Borella F, Carosso M et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients. American Journal of Obstetrics and Gynecology. 2021;224(4):391.e391-391.e397. https://doi.org/10.1016/j. ajog.2020.10.005
  • 52. Woodworth KR, Olsen EO, Neelam V, Lewis EL, Galang RR et al. Birth and Infant Outcomes Following LaboratoryConfirmed SARS-CoV-2 Infection in Pregnancy - SET-NET, 16 Jurisdictions, March 29-October 14, 2020. Mortality and Morbidity Weekly Report. 2020;69(44):1635-1640. doi: 10.15585/mmwr.mm6944e2
  • 53. Li R, Yin T, Fang F, Li Q, Chen J et al. Potential risks of SARS-Cov-2 infection on reproductive health. Reproductive Biomedicine Online. 2020. https://doi.org/10.1016/j. rbmo.2020.04.018
  • 54. Narang K, Enninga EAL, Gunaratne MD, Ibirogba ER, Trad ATA et al., editors. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review. Mayo Clinic Proceedings; 95( 8);2020, 1559-1561. https://doi.org/10.1016/j. mayocp.2020.05.011
  • 55. Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P et al. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic. JAMA. 2020;324(7):705-706. doi:10.1001/jama.2020.12746
  • 56. Delahoy MJ, Whitaker M, O’Halloran A, Chai SJ, Kirley PD et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020. Mortality and Morbidity Weekly Report. 2020;69(38):1347- 1354. doi: 10.15585/mmwr.mm6938e1
  • 57. Walker KF, O’Donoghue K, Grace N, Dorling J, Comeau JL et al. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. British Journal of Obstetrics and Gynecology. 2020; 127 (11): 1324-1336. https://doi.org/10.1111/1471- 0528.16362
  • 58. Flaherman VJ, Afshar Y, Boscardin J, Keller RL, Mardy A et al. Infant Outcomes Following Maternal Infection with SARSCoV-2: First Report from the PRIORITY Study. Clinical Infectious Diseases. 2020. https://doi.org/10.1093/cid/ciaa1411
  • 59. Huntley BJ, Huntley ES, Di Mascio D, Chen T, Berghella V et al. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstetrics & Gynecology.136(2);303-312. doi10.1097/AOG.0000000000004010
  • 60. Kim DH. Clinical implications of coronavirus disease 2019 in neonates. Clinical and Experimental Pediatrics. 2021;64(4):157-164. doi: 10.3345/cep.2020.01795
  • 61. Erol SA, Polat N, Akdas S, Aribal Ayral P, Anuk AT et al. Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection. Journal of Medical Virology. 2021. https://doi.org/10.1002/ jmv.27064
  • 62. Tanacan A, Yazihan N, Erol SA, Anuk AT, Yucel Yetiskin FD et al. The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study. Cytokine. 2021;140:155431. https://doi.org/10.1016/j.cyto.2021.155431
  • 63. Erol SA, Tanacan A, Anuk AT, Tokalioglu EO, Biriken D et al. Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID-19 and its association with composite adverse perinatal outcomes. Journal of Medical Virology. 2021;93(4):2350-2358. https://doi.org/10.1002/ jmv.26725
  • 64. Anuk AT, Polat N, Akdas S, Erol SA, Tanacan A et al. The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy. Biological Trace Element Research. 199(1);3608–3617. https:// doi.org/10.1007/s12011-020-02496-y
  • 65. Anuk AT, Tanacan A, Yetiskin FDY, Buyuk GN, Senel SA et al. Doppler assessment of the fetus in pregnant women recovered from COVID-19. J Obstet Gynaecol Res. 2021;47(5):1757- 1762. https://doi.org/10.1111/jog.14726
  • 66. Ayhan SG, Tanacan A, Atalay A, Sinaci S, Tokalioglu EO et al. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study. Journal of Perinatal Medicine. 2021. https://doi.org/10.1515/ jpm-2020-0512
  • 67. Pierce-Williams RAM, Burd J, Felder L, Khoury R, Bernstein PS et al. Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study. American Journal of Obstetrics and Gynecolology MFM. 2020; 2 (3): 100134. https://doi.org/10.1016/j.ajogmf.2020.100134
  • 68. Metz TD, Clifton RG, Hughes BL, Sandoval G, Saade GR et al. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstetrics Gynecolology. 2021;137(4):571-580. doi: 10.1097/ AOG.0000000000004339
  • 69. Tanacan A, Anuk AT, Erol SA, Keskin HL, Altinboga O et al. The effect of real-time polymerase chain reaction cycle threshold values on perinatal outcomes of pregnant women with COVID-19. Journal of Maternal- Fetal and Neonatal Medicine. 2021:1-8. https://doi.org/10.1080/14767058.2021.1 900105
  • 70. Patel A, Jernigan DB. Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December 31, 2019-February 4, 2020. Mortality and Morbidity Weekly Report. 2020;69(5):140- 146. doi: 10.15585/mmwr.mm6905e1
  • 71. Weissleder R, Lee H, Ko J, Pittet MJ. COVID-19 diagnostics in context. Science Translational Medicine. 2020;12(546). doi: 10.1126/scitranslmed.abc1931
  • 72. Dinnes J, Deeks JJ, Berhane S, Taylor M, Adriano A et al. Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection. Cochrane Database Systemic Reviews. 2021; 3 (3): Cd013705. https://doi.org/10.1002/14651858. CD013705.pub2
  • 73. Cheng MP, Yansouni CP, Basta NE, Desjardins M, Kanjilal S et al. Serodiagnostics for Severe Acute Respiratory SyndromeRelated Coronavirus 2 : A Narrative Review. Annals of Internal Medicine. 2020; 173 (6): 450-460. https://doi.org/10.7326/ M20-2854
  • 74. Narang K, Ibirogba ER, Elrefaei A, Trad ATA, Theiler R et al. SARS-CoV-2 in Pregnancy: A Comprehensive Summary of Current Guidelines. Journal of Clinical Medicine. 2020; 9 (5). doi: 10.3390/jcm9051521
  • 75. ACOG Committee Opinion No. 743: Low-Dose Aspirin Use During Pregnancy. Obstetrics Gynecolology. 2018; 132 (1): e44-e52
  • 76. Conde-Agudelo A, Romero R. SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2021. https://doi.org/10.1016/j.ajog.2021.07.009
  • 77. Sinaci S, Ozden Tokalioglu E, Ocal D, Atalay A, Yilmaz G et al. Does having a high-risk pregnancy influence anxiety level during the COVID-19 pandemic? European Journal of Obstetrics Gynecology and Reproductive Biology. 2020;255:190-196. https://doi.org/10.1016/j.ejogrb.2020.10.055
  • 78. Savasi VM, Parisi F, Patanè L, Ferrazzi E, Frigerio L et al. Clinical findings and disease severity in hospitalized pregnant women with coronavirus disease 2019 (COVID-19). Obstetrics & Gynecology. 2020;136(2):252-258. doi: 10.1097/ AOG.0000000000003979
  • 79. Servante J, Swallow G, Thornton JG, Myers B, Munireddy S et al. Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis. BMC Pregnancy Childbirth. 2021;21(1):108. https://doi.org/10.1186/s12884-021-03568-0
  • 80. Saad AF, Chappell L, Saade GR, Pacheco LD. Corticosteroids in the Management of Pregnant Patients With Coronavirus Disease (COVID-19). Obstetrics and Gynecology. 2020;136(4):823-826.doi: 10.1097/AOG.0000000000004103
  • 81. D’Souza R, Ashraf R, Rowe H, Zipursky J, Clarfield L et al. Pregnancy and COVID-19: pharmacologic considerations. Ultrasound in Obstetrics & Gynecology. 2021;57(2):195-203. https://doi.org/10.1002/uog.23116
  • 82. Wong AY, MacKenna B, Morton CE, Schultze A, Walker AJ et al. Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts. Annals of Rheumatic Diseases. 80(7);1-10.. http://dx.doi.org/10.1136/annrheumdis-2020-219517
  • 83. Tripathy S, Dassarma B, Roy S, Chabalala H, Matsabisa MG. A review on possible modes of action of chloroquine/ hydroxychloroquine: repurposing against SAR-CoV-2 (COVID-19) pandemic. International journal of antimicrobial agents. 2020; 56 (2): 106028. https://doi.org/10.1016/j. ijantimicag.2020.106028
  • 84. Peterson EA, Lynton J, Bernard A, Santillan MK, Bettendorf B. Rheumatologic Medication Use During Pregnancy. Obstetrics & Gynecology. 2020;135(5):1161-1176. doi:10.1097/ AOG.0000000000003755
  • 85. Mangkuliguna G, Glenardi, Susanto N, Pramono LA. Efficacy and Safety of Azithromycin for the Treatment of COVID-19: A Systematic Review and Meta-analysis. Tuberculosis Respiratory Diseases (Seoul). 84(4);2021. doi: https://doi.org/10.4046/ trd.2021.0075
  • 86. Cao B, Wang Y, Wen D, Liu W, Wang J et al. A trial of lopinavir– ritonavir in adults hospitalized with severe Covid-19. New England journal of medicine. 382:1787-1799. doi:10.1056/ NEJMoa2001282
  • 87. Bérard A, Sheehy O, Zhao JP, Vinet E, Quach C et al. Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy. PloS one. 2021;16(5):e0251746. https://doi.org/10.1371/journal. pone.0251746
  • 88. Burwick RM, Yawetz S, Stephenson KE, Collier AY, Sen P et al. Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19. Clinical Infectious Diseases. 2020. doi: 10.1093/cid/ciaa1466
  • 89. Louchet M, Sibiude J, Peytavin G, Picone O, Tréluyer JM et al. Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019. American Journal of Obstetrics and Gynecology MFM. 2020;2(3):100159. https://doi.org/10.1016/j.ajogmf.2020.100159
  • 90. Yaqoub S, Ahmad S, Mansouri Z, Pallivalapila A, El Kassem W et al. Management of life-threatening acute respiratory syndrome and severe pneumonia secondary to COVID-19 in pregnancy: A case report and literature review. Clinical Case Reports. 2021;9(1):137-143. https://doi.org/10.1002/ccr3.3485
  • 91. Goncu Ayhan S, Oluklu D, Atalay A, Menekse Beser D, Tanacan A et al. COVID-19 vaccine acceptance in pregnant women. International Journal of Gynaecology and Obstetrics. 2021. https://doi.org/10.1002/ijgo.13713
  • 92. Creech CB, Walker SC, Samuels RJ. SARS-CoV-2 vaccines. JAMA. 2021;325(13):1318-1320. doi:10.1001/jama.2021.3199
  • 93. Male V. Are COVID-19 vaccines safe in pregnancy? Nature Reviews Immunology. 2021;21(4):200-201. https://doi. org/10.1038/s41577-021-00525-y
  • 94. Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. New England Journal of Medicine 384:2273- 2282. doi: 10.1056/NEJMoa2104983
  • 95. Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L et al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. Journal of Clinical Investigation. 2021.131(13); :e150319. doi: 10.1172/JCI150319
  • 96. Sahin D, Erol SA, Tanacan A, Ozcan N, Keskin HL et al. Protective equipment to use in the vaginal delivery of the pregnant woman with suspected or diagnosed coronavirus disease 2019: delivery table shield. American Journal of Obstetrics & Gynecology. 2020;223(4):599-601.doi: https://doi. org/10.1016/j.ajog.2020.06.021
  • 97. Martínez-Perez O, Vouga M, Cruz Melguizo S, Forcen Acebal L, Panchaud A et al. Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain. JAMA. 2020;324(3):296-299. doi:10.1001/jama.2020.10125
  • 98. Herman JA, Urits I, Kaye AD, Urman RD, Viswanath O. COVID-19: Obstetric anesthesia care considerations. Journal of clinical anesthesia. 2020;65:109860.doi: 10.1016/j. jclinane.2020.109860
  • 99. Salvatore CM, Han JY, Acker KP, Tiwari P, Jin J et al. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child and Adolescant Health. 2020.4(10);721-727. https://doi.org/10.1016/S2352- 4642(20)30235-2
APA şahin D, Tanacan A, Webster S, moraloglu tekin o (2021). Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. , 3312 - 3326. 10.3906/sag-2106-134
Chicago şahin Dilek,Tanacan Atakan,Webster Sophia,moraloglu tekin ozlem Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. (2021): 3312 - 3326. 10.3906/sag-2106-134
MLA şahin Dilek,Tanacan Atakan,Webster Sophia,moraloglu tekin ozlem Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. , 2021, ss.3312 - 3326. 10.3906/sag-2106-134
AMA şahin D,Tanacan A,Webster S,moraloglu tekin o Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. . 2021; 3312 - 3326. 10.3906/sag-2106-134
Vancouver şahin D,Tanacan A,Webster S,moraloglu tekin o Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. . 2021; 3312 - 3326. 10.3906/sag-2106-134
IEEE şahin D,Tanacan A,Webster S,moraloglu tekin o "Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond." , ss.3312 - 3326, 2021. 10.3906/sag-2106-134
ISNAD şahin, Dilek vd. "Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond". (2021), 3312-3326. https://doi.org/10.3906/sag-2106-134
APA şahin D, Tanacan A, Webster S, moraloglu tekin o (2021). Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turkish Journal of Medical Sciences, 51(Özel Sayı 1), 3312 - 3326. 10.3906/sag-2106-134
Chicago şahin Dilek,Tanacan Atakan,Webster Sophia,moraloglu tekin ozlem Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turkish Journal of Medical Sciences 51, no.Özel Sayı 1 (2021): 3312 - 3326. 10.3906/sag-2106-134
MLA şahin Dilek,Tanacan Atakan,Webster Sophia,moraloglu tekin ozlem Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turkish Journal of Medical Sciences, vol.51, no.Özel Sayı 1, 2021, ss.3312 - 3326. 10.3906/sag-2106-134
AMA şahin D,Tanacan A,Webster S,moraloglu tekin o Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turkish Journal of Medical Sciences. 2021; 51(Özel Sayı 1): 3312 - 3326. 10.3906/sag-2106-134
Vancouver şahin D,Tanacan A,Webster S,moraloglu tekin o Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turkish Journal of Medical Sciences. 2021; 51(Özel Sayı 1): 3312 - 3326. 10.3906/sag-2106-134
IEEE şahin D,Tanacan A,Webster S,moraloglu tekin o "Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond." Turkish Journal of Medical Sciences, 51, ss.3312 - 3326, 2021. 10.3906/sag-2106-134
ISNAD şahin, Dilek vd. "Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond". Turkish Journal of Medical Sciences 51/Özel Sayı 1 (2021), 3312-3326. https://doi.org/10.3906/sag-2106-134