Yıl: 2021 Cilt: 59 Sayı: 2 Sayfa Aralığı: 170 - 174 Metin Dili: İngilizce İndeks Tarihi: 30-01-2022

Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome

Öz:
Introduction: While restless legs syndrome (RLS) pathophysiology is unclear, it is understood that inflammatory processes play a role. In this research, the role of red cell distribution width (RDW), plateletcrit, erythrocyte sedimentation rate (ESR), Creactive protein (CRP) as an inflammatory biomarker in the RLS was investigated. Methods: One hundred and eight patients diagnosed with RLS and one hundred and six healthy control group with similar demographic characteristics were included in this study. Total blood count (RDW, WBC, platelet, neutrophil, lymphocyte, plateletcrit, neutrophil lymphocyte ratio (NLR)), CRP, ESR, glucose, creatinine, ferritin, and vitamin B12 were compared in both groups. Demographic and laboratory values were recorded in SPSS. Results: RDW, plateletcrit, platelet and ESR results were statistically higher in the RLS group compared to the control group. Neutrophil, CRP and NLR were higher in the RLS group without significance. There was positive correlations between RDW and RLS group, CRP, ESR, platelet and NLR. In multivariate analysis, RDW was found as a significant independent predictor of RLS after adjusting for other risk factors (p=0.027). In a receiver operating characteristic curve analysis, an RDW value of 13.55% was identified as an effective cut-off RLS (area under curve=0.597, 95% CI=0.518–0.675, p=0.014). An RDW value of more than 13.55 % yielded a sensitivity of 60.2% and a specificity of 60.4%. Conclusion: Our study first investigated RDW and plateletcrit as an inflammatory biomarker in RLS patients and revealed that RDW is an independent predictor in RLS patients.
Anahtar Kelime:

Huzursuz Bacak Sendrom Hastalarında İnflamasyonun Plateletkrit, RDW, Sedimantasyon ve CRP ile Değerlendirilmesi

Öz:
Giris ve Amaç: Huzursuz bacak sendromu (HBS) patofizyolojisi tam olarak bilinmemekle birlikte inflamatuvar süreçlerin rol oynadığı anlaşılmaktadır. Bu araştırmada HBS'de kırmızı hücre dağılım genişliği (RDW), platelekrit, eritrosit sedimantasyon hızı (ESR), C-reaktif protein (CRP)'nin inflamatuar bir biyobelirteç olarak rolü araştırılmıştır. Yöntem ve Gereçler: Çalışmaya HBS tanısı almış 108 hasta ve benzer demografik özelliklere sahip 106 sağlıklı kontrol grubu dahil edildi. Toplam kan sayımı (RDW, WBC, trombosit, nötrofil, lenfosit, platelekrit, nötrofil lenfosit oranı (NLO)), CRP, ESR, glukoz, kreatinin, ferritin ve B12 vitamini her iki grupta karşılaştırıldı. Demografik ve laboratuvar değerleri SPSS'ye kaydedildi.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
  • 1. Moreira NCV, Damasceno RS, Medeiros CAM, et al. Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients. Braz J Med Biol Res 2008; 41(10):932-37.
  • 2. Ghorayeb I, Tison F. Epidemiology of restless legs syndrome. Rev Neurol 2009;165(8-9):641-49.
  • 3. Demir AU, Ardıc S, Fırat H, et al. M for the TAPES Investigation Committee. Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study. Sleep and Biological Rhytmes 2015;13:298-308.
  • 4. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.Sleep Med 2003; 4(2):101-19.
  • 5. Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 2016;87(24):2585-93.
  • 6. Weinstock LB, Walters AS, Paueksakon P. Restless legs syndrome e Theoretical roles of inflammatory and immunemechanisms. Sleep Medicine Reviews 2012;16(4):341-54.
  • 7. Gjevre JA, Taylor Gjevre RM. Restless legs syndrome as a comorbidity in rheumatoid arthritis. Autoimmune Dis 2013:352782
  • 8. Weinstock LB, Bosworth BP, Scherl EJ, Li E, Iroku U, Munsell MA, Mullen GE, Walters AS. Crohn’s disease is associated with restless legs syndrome. Inflamm Bowel Dis 2010;16(2):275-79.
  • 9. Weinstock LB, Walters AS, Mullin GE, Duntley SP. Celiac disease is associated with restless legs syndrome. Dig Dis Sci 2010; 55(6):1667- 73.
  • 10. Patton SM, Ponnuru P, Snyder AM, Podskalny GD, Connor JR. Hypoxiainducible factor pathway activation in restless legs syndrome patients. Eur J Neurol 2011; 18(11):1329-35.
  • 11. Hassan N, Pineau CA, Clarke AE, Vinet E, Ng R, Bernatsky S. Systemic lupus and risk of restless legs syndrome. J Rheumatol 2011;38(5):874-6.
  • 12. Imtiyaz HZ, Simon MC. Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol 2010;345:105-120.
  • 13. Tak AZA, Sengul Y.Evaluation of Inflammation with Neutrophil-tolymphocyte Ratio and Platelet-to-lymphocyte Ratio in Restless Legs Syndrome.Turk J Neurol 2018;24(3):259-63.
  • 14. Varım C, Acar BA, Uyanık MS, et al. Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome. Singapore Med J 2016;57(9):514-16.
  • 15. Gul M, Uyarel H, Ergelen M, et al. The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up. Coron Artery Dis 2012; 23(5):330-36.
  • 16. Gul M, Uyarel H, Akgul O, et al. Long-term prognostic significance of admission plateletcrit values in patients with non-ST elevation myocardial infarction. Blood Coagul Fibrinolysis 2016;27(6):696-01.
  • 17.Wang YQ, Zhi QJ, Wang XY, Yue DS, Li K, Jiang RC. Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncol Lett 2017;14(4):4331-38.
  • 18. Balta S, Demırkol S, Kucuk U.The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice. Hemodial Int 2013;17(4):668–69.
  • 19. Akkaya E, Gul M, Ugur M. Platelet to lymphocyte ratio: a simple and valuable prognostic marker for acute coronary syndrome. Int J Cardiol 2014;177(2):597–98.
  • 20. Ugur M, Ayhan E, Bozbay M, et al.The independent assocıatıon of plateletcrıt wıth long-term outcomes in patıents undergoıng prımary percutaneous coronary interventıon. J Crit Care 2014;29(6): 978-81.
  • 21. Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 2005;20(2):83–90.
  • 22. Kiefer CR, Snyder LM. Oxidation and erythrocyte senescence. Curr Opin Hematol 2000;7(2):113-16.
  • 23. Sonkaya AR, Ceylan M. Investigation of inflammation with neutrophil/lymphocyte ratio in restless legs syndrome. J Surg Med 2019;3(4):288-91.
  • 24. Higuchi T, Abe M, Mizuno M, et al.Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis.Sleep Med;16(8):941-48.
  • 25. Felker GM, Allen LA, S. J. Pocock SJ, et al. CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM program and the Duke databank. J Am Coll Cardiol 2007;50(1): 40-7.
  • 26. Kara H, Degirmenci S,Bayir A, et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatr Dis Treat 2015; 11: 733–739.
  • 27. Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol 2010;15(3):37-40.
  • 28. Arhan M, Onal İK, Tas A, et al. The role of red cell distribution width as a marker in inflammatory bowel disease. Turk J Med Sci 2011;41(2):227-34.
  • 29. Sarikaya S, Sahin S, Akyol L, Börekçi B, Yılmaz YK, Altunkaş F, Karaman K.Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient? Afr Health Sci2011;14(1):267-72.
APA Bastug Gul Z, Gozubatik-Celik R (2021). Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. , 170 - 174.
Chicago Bastug Gul Zeynep,Gozubatik-Celik Rabia Gokcen Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. (2021): 170 - 174.
MLA Bastug Gul Zeynep,Gozubatik-Celik Rabia Gokcen Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. , 2021, ss.170 - 174.
AMA Bastug Gul Z,Gozubatik-Celik R Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. . 2021; 170 - 174.
Vancouver Bastug Gul Z,Gozubatik-Celik R Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. . 2021; 170 - 174.
IEEE Bastug Gul Z,Gozubatik-Celik R "Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome." , ss.170 - 174, 2021.
ISNAD Bastug Gul, Zeynep - Gozubatik-Celik, Rabia Gokcen. "Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome". (2021), 170-174.
APA Bastug Gul Z, Gozubatik-Celik R (2021). Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. Ege Klinikleri Tıp Dergisi, 59(2), 170 - 174.
Chicago Bastug Gul Zeynep,Gozubatik-Celik Rabia Gokcen Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. Ege Klinikleri Tıp Dergisi 59, no.2 (2021): 170 - 174.
MLA Bastug Gul Zeynep,Gozubatik-Celik Rabia Gokcen Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. Ege Klinikleri Tıp Dergisi, vol.59, no.2, 2021, ss.170 - 174.
AMA Bastug Gul Z,Gozubatik-Celik R Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. Ege Klinikleri Tıp Dergisi. 2021; 59(2): 170 - 174.
Vancouver Bastug Gul Z,Gozubatik-Celik R Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome. Ege Klinikleri Tıp Dergisi. 2021; 59(2): 170 - 174.
IEEE Bastug Gul Z,Gozubatik-Celik R "Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome." Ege Klinikleri Tıp Dergisi, 59, ss.170 - 174, 2021.
ISNAD Bastug Gul, Zeynep - Gozubatik-Celik, Rabia Gokcen. "Evaluation of Inflammation With Plateletcrit, RDW, Sedimentation and CRP in Patients With Restless Legs Syndrome". Ege Klinikleri Tıp Dergisi 59/2 (2021), 170-174.