The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection

AYDIN, Cihan; ARPA, Medeni; emlek, nadir; Ergül, Elif; ÖZTÜRK, Muhammet; GÜNDOĞDU, Hasan; Yilmaz, Ahmet Seyda; KOÇ, Haldun

doi:10.30714/j-ebr.2021471926

The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection

Nadir EMLEK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Ahmet Seyda YILMAZ, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Elif ERGÜL, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Hasan GÜNDOĞDU, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Rize, Türkiye)

Medeni ARPA, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Türkiye)

Haldun KOÇ, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Muhammet ÖZTÜRK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Cihan AYDIN (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Experimental Biomedical Research

2 0

Yıl: 2021 Cilt: 4 Sayı: 4 Sayfa Aralığı: 314 - 321 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2021471926 İndeks Tarihi: 10-02-2022

The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection

Öz:

Aim: COVID-19 infections the tissue through angiotensin converting enzyme 2 receptor, which is alsoexpressed on endothelial cells. Endothelial dysfunction may be associated with lung involvement. Asymmetricdimethylarginine (ADMA) is an indirect marker of endothelial dysfunction. The aim of our study was toevaluate ADMA concentrations and to identify its association with lung involvement in patients with COVID 19 disease. Methods: We included 42 patients with COVID-19 infection and lung involvement (Group 1). Forty-two ageand sex matched patients without pneumonia acted as the control group (Group 2). All patients gave bloodsamples for ADMA at the 1st month control visit after discharge. We compared C-reactive protein (CRP) andADMA concentrations in addition to routine biochemical parameters between groups. Results: Patients with lung involvement had higher admission glucose, CRP, and ADMA concentrations, anddisplayed lower hemoglobin concentration and lymphocyte count compared to patients without lunginvolvement. Although patients with lung involvement had higher ADMA concentrations with respect to thosewithout; plasma ADMA levels were also higher than normal values in control group. Multivariate analysisidentified log CRP concentration (OR= 3.047, 95% CI=1.881-5.023, p<0.001) as the independent predictorfor lung involvement. And, there was a correlation between ADMA and CRP (r: 0.318, p: 0.003). Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction inCOVID-19 patients whether they have pneumonia or not.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	emlek n, Yilmaz A, Ergül E, GÜNDOĞDU H, ARPA M, KOÇ H, ÖZTÜRK M, AYDIN C (2021). The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. , 314 - 321. 10.30714/j-ebr.2021471926
Chicago	emlek nadir,Yilmaz Ahmet Seyda,Ergül Elif,GÜNDOĞDU Hasan,ARPA Medeni,KOÇ Haldun,ÖZTÜRK Muhammet,AYDIN Cihan The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. (2021): 314 - 321. 10.30714/j-ebr.2021471926
MLA	emlek nadir,Yilmaz Ahmet Seyda,Ergül Elif,GÜNDOĞDU Hasan,ARPA Medeni,KOÇ Haldun,ÖZTÜRK Muhammet,AYDIN Cihan The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. , 2021, ss.314 - 321. 10.30714/j-ebr.2021471926
AMA	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. . 2021; 314 - 321. 10.30714/j-ebr.2021471926
Vancouver	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. . 2021; 314 - 321. 10.30714/j-ebr.2021471926
IEEE	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C "The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection." , ss.314 - 321, 2021. 10.30714/j-ebr.2021471926
ISNAD	emlek, nadir vd. "The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection". (2021), 314-321. https://doi.org/10.30714/j-ebr.2021471926

APA	emlek n, Yilmaz A, Ergül E, GÜNDOĞDU H, ARPA M, KOÇ H, ÖZTÜRK M, AYDIN C (2021). The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research, 4(4), 314 - 321. 10.30714/j-ebr.2021471926
Chicago	emlek nadir,Yilmaz Ahmet Seyda,Ergül Elif,GÜNDOĞDU Hasan,ARPA Medeni,KOÇ Haldun,ÖZTÜRK Muhammet,AYDIN Cihan The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research 4, no.4 (2021): 314 - 321. 10.30714/j-ebr.2021471926
MLA	emlek nadir,Yilmaz Ahmet Seyda,Ergül Elif,GÜNDOĞDU Hasan,ARPA Medeni,KOÇ Haldun,ÖZTÜRK Muhammet,AYDIN Cihan The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research, vol.4, no.4, 2021, ss.314 - 321. 10.30714/j-ebr.2021471926
AMA	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research. 2021; 4(4): 314 - 321. 10.30714/j-ebr.2021471926
Vancouver	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection. Experimental Biomedical Research. 2021; 4(4): 314 - 321. 10.30714/j-ebr.2021471926
IEEE	emlek n,Yilmaz A,Ergül E,GÜNDOĞDU H,ARPA M,KOÇ H,ÖZTÜRK M,AYDIN C "The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection." Experimental Biomedical Research, 4, ss.314 - 321, 2021. 10.30714/j-ebr.2021471926
ISNAD	emlek, nadir vd. "The relationship of serum asymmetric dimethylarginine concentrations and lunginvolvement in patients with COVID-19 infection". Experimental Biomedical Research 4/4 (2021), 314-321. https://doi.org/10.30714/j-ebr.2021471926