Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice

kurtul, ekin; Bahtiyar, Bade Cevriye; SALTAN, HAYRIYE GÜLÇIN; Bahadır Acıkara, Özlem; özbek, hanefi; SAKUL, AYSE ARZU; Kirmizi Sonmez, N. Ipek

doi:10.33808/clinexphealthsci.797747

Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice

Ayse Arzu Sakul, (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Ekin Kurtul, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)

HANEFİ ÖZBEK, (İzmir Bakırçay Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, İzmir, Türkiye)

Neriman İpek KIRMIZI, (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Bade Cevriye Bahtiyar, (İstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksek Okulu, İstanbul, Türkiye)

Gülçin SALTAN İŞCAN, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)

Özlem BAHADIR ACIKARA (Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)

Clinical and Experimental Health Sciences

9 1

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 74 - 80 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.797747 İndeks Tarihi: 12-01-2022

Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice

Öz:

Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin is the primary component responsible of this activity. Methods: The extracts of aerial parts of Scorzonera tomentosa, S. mollis ssp. szowitsii, S. suberosa ssp. suberosa, S. eriophora, S. acuminata, S. sublanata and S. cana var. jacquiniana were used in the experiment. Additionally, rutin, which has been analysed and detected by using HPLC qualitatively and quantitatively in some Scorzonera species, was also tested for its antidiabetic activity in the same conditions. An alloxaninduced diabetic mice test model was used in order to verify antidiabetic activity. Antidiabetic activities of the 9 groups (n=5; each) were measured at four different times: before Scorzonera extracts and rutin treatment and after 1, 2 and 4 hours of treatments. Results: S. sublanata extract exhibited the highest antidiabetic activity and at 100 mg/kg dose, it significantly reduced blood glucose levels measured after 1, 2 and 4 hours of treatments when compared to isotonic saline solution group (diabetic control group). S. cana var. jacquiniana extract also displayed notable decrease after 4 hours of treatment. Significant lowering effect on blood glucose level was also observed by treatment with rutin in all tested times at 100 mg/kg i.p. injection. According to the HPLC analyses the highest rutin content was determined in the S. acuminata aerial parts. Conclusion: Rutin content and the antidiabetic activity of the plant extracts were not correlated as displayed in this present study. Further studies should be performed to reveal responsible compunds for antidiabetic activity.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SAKUL A, kurtul e, özbek h, Kirmizi Sonmez N, Bahtiyar B, SALTAN H, Bahadır Acıkara Ö (2021). Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. , 74 - 80. 10.33808/clinexphealthsci.797747
Chicago	SAKUL AYSE ARZU,kurtul ekin,özbek hanefi,Kirmizi Sonmez N. Ipek,Bahtiyar Bade Cevriye,SALTAN HAYRIYE GÜLÇIN,Bahadır Acıkara Özlem Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. (2021): 74 - 80. 10.33808/clinexphealthsci.797747
MLA	SAKUL AYSE ARZU,kurtul ekin,özbek hanefi,Kirmizi Sonmez N. Ipek,Bahtiyar Bade Cevriye,SALTAN HAYRIYE GÜLÇIN,Bahadır Acıkara Özlem Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. , 2021, ss.74 - 80. 10.33808/clinexphealthsci.797747
AMA	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. . 2021; 74 - 80. 10.33808/clinexphealthsci.797747
Vancouver	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. . 2021; 74 - 80. 10.33808/clinexphealthsci.797747
IEEE	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö "Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice." , ss.74 - 80, 2021. 10.33808/clinexphealthsci.797747
ISNAD	SAKUL, AYSE ARZU vd. "Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice". (2021), 74-80. https://doi.org/10.33808/clinexphealthsci.797747

APA	SAKUL A, kurtul e, özbek h, Kirmizi Sonmez N, Bahtiyar B, SALTAN H, Bahadır Acıkara Ö (2021). Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. Clinical and Experimental Health Sciences, 11(1), 74 - 80. 10.33808/clinexphealthsci.797747
Chicago	SAKUL AYSE ARZU,kurtul ekin,özbek hanefi,Kirmizi Sonmez N. Ipek,Bahtiyar Bade Cevriye,SALTAN HAYRIYE GÜLÇIN,Bahadır Acıkara Özlem Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. Clinical and Experimental Health Sciences 11, no.1 (2021): 74 - 80. 10.33808/clinexphealthsci.797747
MLA	SAKUL AYSE ARZU,kurtul ekin,özbek hanefi,Kirmizi Sonmez N. Ipek,Bahtiyar Bade Cevriye,SALTAN HAYRIYE GÜLÇIN,Bahadır Acıkara Özlem Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. Clinical and Experimental Health Sciences, vol.11, no.1, 2021, ss.74 - 80. 10.33808/clinexphealthsci.797747
AMA	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. Clinical and Experimental Health Sciences. 2021; 11(1): 74 - 80. 10.33808/clinexphealthsci.797747
Vancouver	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice. Clinical and Experimental Health Sciences. 2021; 11(1): 74 - 80. 10.33808/clinexphealthsci.797747
IEEE	SAKUL A,kurtul e,özbek h,Kirmizi Sonmez N,Bahtiyar B,SALTAN H,Bahadır Acıkara Ö "Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice." Clinical and Experimental Health Sciences, 11, ss.74 - 80, 2021. 10.33808/clinexphealthsci.797747
ISNAD	SAKUL, AYSE ARZU vd. "Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan-Induced Diabetic Mice". Clinical and Experimental Health Sciences 11/1 (2021), 74-80. https://doi.org/10.33808/clinexphealthsci.797747