The alteration of lymphocyte subsets in idiopathic granulomatous mastitis

Kadoglou, Naim; ARTAC, HASIBE; Ceylan, Ayca; Ozdemir, Hulya; Köksal, Hande

doi:10.3906/sag-2012-192

The alteration of lymphocyte subsets in idiopathic granulomatous mastitis

Ayça EMSEN, (Selçuk Üniversitesi, Tıp Fakültesi, Pediatrik İmmünoloji ve Alerji Anabilim Dalı, Konya, Türkiye)

Hande KÖKSAL, (Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, Konya Şehir Hastanesi, Genel Cerrahi Anabilim Dalı, Konya, Türkiye)

Hulya UCARYILMAZ, (Selçuk Üniversitesi, Tıp Fakültesi, Pediatrik İmmünoloji ve Alerji Anabilim Dalı, Konya, Türkiye)

Naim KADOGLOU, (Department of General Surgery, London North West Healthcare NHS Trust, Northwick Park Hospital, London, UK)

Hasibe ARTAC (Selçuk Üniversitesi, Tıp Fakültesi, Pediatrik İmmünoloji ve Alerji Anabilim Dalı, Konya, Türkiye)

Turkish Journal of Medical Sciences

3 1

Yıl: 2021 Cilt: 51 Sayı: 4 Sayfa Aralığı: 1905 - 1911 Metin Dili: İngilizce DOI: 10.3906/sag-2012-192 İndeks Tarihi: 12-01-2022

The alteration of lymphocyte subsets in idiopathic granulomatous mastitis

Öz:

Background and aim: This study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM. Materials and methods: This study includes 51 pathologically proven IGM patients (active disease: 26 and in remission: 25) and 28 healthy volunteers. The analyses of lymphocyte subsets were performed by flow cytometric immunophenotyping. Results: The percentage of T helper lymphocyte of all IGM patients were lower than control groups (p = 0.001). Absolute cytotoxic T lymphocyte count (p = 0.03), both percentage (p = 0.035) and absolute count (p = 0.002) of the natural killer cells, and both percentage (p = 0.038) and absolute count (p = 0.008) of natural killer T cells, were higher than the control group. The T helper lymphocyte percentage of the patients with active disease was lower than the control group (p = 0.0003). The absolute cytotoxic T lymphocyte (p = 0.029) and natural killer T cells (p = 0.012) of the patients with active disease were higher than the control group. Conclusion: Idiopathic granulomatous mastitis is defined as a localized form of granulomatous disorders. However, the observed changes in T cells, NK, and NKT cells suggest that there is systemic immune dysregulation in patients with IGM.Key words: Idiopathic granulomatous mastitis, lymphocyte subsets, autoimmunity, etiopathogenesis

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Altintoprak F, Kivilcim T, Ozkan OV. Aetiology of idiopathic granulomatous mastitis. World Journal of Clinical Cases 2014; 2 (12): 852-858. doi:10.12998/wjcc.v2.i12.852
2. Benson JR, Dumitru D. Idiopathic granulomatous mastitis: presentation, investigation and management. Future Oncology 2016; 12 (11): 1381-1394. doi:10.2217/fon-2015-0038
3. Altintoprak F, Karakece E, Kivilcim T, Dikicier E, Cakmak G et al. Idiopathic granulomatous mastitis: an autoimmune disease? The Scientific World Journal 2013; 148727. doi: 10.1155/2013/148727
4. Sheybani F, Naderi HR, Gharib M, Sarvghad M, Mirfeizi Z. Idiopathic granulomatous mastitis: long-discussed but yetto-be-known. Autoimmunity 2016; 49 (4): 236-239. doi: 10.3109/08916934.2016.1138221
5. Salesi M, Karimifar M, Salimi F, Mahzouni P. A case of granulomatous mastitis with erythema nodosum and arthritis. Rheumatology International 2011; 31 (8): 1093-1095. doi: 10.1007/s00296-009-1273-0
6. Binesh F, Shiryazdi M, Bagher Owlia M, Azimi S. Idiopathic granulomatous mastitis, erythema nodosum and bilateral ankle arthritis in an Iranian woman. BMJ Case Reports 2013; 2013: bcr2012007636. doi: 10.1136/bcr-2012-007636
7. Alungal J, Abdulla MC, Narayan R. Idiopathic granulomatous mastitis with erythema nodosum and polyarthritis. Reumatismo 2016; 68 (2): 97-99. doi:10.4081/reumatismo.2016.844
8. Zabetian S, Friedman BJ, McHargue C. A case of idiopathic granulomatous mastitis associated with erythema nodosum, arthritis, and reactive cough. JAAD Case Reports 2016; 2 (2): 125-127. doi: 10.1016/j.jdcr.2016.01.011
9. Akın M, Karabacak H, Esendağlı G, Yavuz A, Gültekin S et al. Coexistence of idiopathic granulomatous mastitis and erythemanodosum: successful treatment with corticosteroids. Turkish Journal of Medical Sciences 2017; 47 (5): 1590-1592. doi: 10.3906/sag-1611-100
10. Fruchter R, Castilla C, Ng E, Pomeranz MK, Femia AN. Erythema nodosum in association with idiopathic granulomatous mastitis: a case series and review of the literature. Journal of the European Academy of Dermatology and Venereology 2017; 31 (9): e391-e393. doi: 10.1111/ jdv.14194
11. Letourneux C, Diemunsch P, Korganow AS, Akladios CY, Bellocq JP et al. First report of granulomatous mastitis associated with Sjögren’s syndrome. World Journal of Surgical Oncology 2013; 11: 268. doi:10.1186/1477-7819-11-268
12. Erhan Y, Veral A, Kara E, Ozdemir N, Kapkac M et al. A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis. The Breast 2000; 9 (1): 52-56. doi: 10.1054/brst.1999.0072
13. Chen L, Zhang XY, Wang YV, Zhao QF, Ding HY. Granulomatous lobular mastitis: a clinicopathological analysis of 300 cases. Zhonghua Bing Li Xue Za Zhi. 2019; 48 (3): 231-236 (in Chinese). doi: 10.3760/cma.j.is sn.0529-5807.2019.03.012
14. Koksal H. Human leukocyte antigens class I and II in patients with idiopathic granulomatous mastitis. American Journal of Surgery 2019; 218 (3): 605-608. doi: 10.1016/j. amjsurg.2019.01.038
15. Lee BW, Yap HK, Chew FT, Quah TC, Prabhakaran K et al. Age- and sex-related changes in lymphocyte subpopulations of healthy Asian subjects: from birth to adulthood. Cytometry 1996; 26 (1): 8-15. doi:10.1002/(SICI)1097- 0320(19960315)26:1<8::AID-CYTO2>3.0.CO;2-E
16. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. American Journal of Clinical Pathology 1972; 58: 642-646. doi:10.1093/ajcp/58.6.642
17. Cohen C. Granulomatous mastitis. A review of 5 cases. South African Medical Journal 1977; 52 (1): 14-16.
18. Ozel L, Unal A, Unal E, Kara M, Erdoğdu E et al. Granulomatous mastitis: is it an autoimmune disease? Diagnostic and therapeutic dilemmas. Surgery Today 2012; 42 (8): 729-733. doi: 10.1007/s00595-011-0046-z
19. Koksal H. The clinical utility of autoantibodies in patients with idiopathic granulomatous mastitis. Journal of Investigative Surgery 2020; 1-5. doi: 10.1080/08941939.2020.1861666
20. Koksal H, Vatansev H, Artac H, Kadoglou N. The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis. Clinical Rheumatology 2020; 39 (5): 1671-1677. doi:10.1007/s10067-020-04925-8
21. Co DO, Hogan LH, Il-Kim S, Sandor M. T cell contributions to the different phases of granuloma formation. Immunology Letters 2004; 92 (1-2): 135-142. doi: 10.1016/j.imlet.2003.11.023
22. Mannering SI, Zhong J, Cheers C. T-cell activation, proliferation and apoptosis in primary Listeria monocytogenes infection. Immunology 2002; 106 (1): 87-95. doi: 10.1046/j.1365- 2567.2002.01408.x
23. Mannering SI, Cheers C. Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection. Infection and Immunity 2002; 70 (1): 27-35. doi: 10.1128/iai.70.1.27-35.2002
24. Kobayashi T, Kawamura H, Kanda Y, Matsumoto H, Saito S et al. Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-γ and interleukin-10. Immunology 2012; 136 (1): 86-95. doi: 10.1111/j.1365-2567.2012.03562.x

APA	Ceylan A, Köksal H, Ozdemir H, Kadoglou N, ARTAC H (2021). The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. , 1905 - 1911. 10.3906/sag-2012-192
Chicago	Ceylan Ayca,Köksal Hande,Ozdemir Hulya,Kadoglou Naim,ARTAC HASIBE The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. (2021): 1905 - 1911. 10.3906/sag-2012-192
MLA	Ceylan Ayca,Köksal Hande,Ozdemir Hulya,Kadoglou Naim,ARTAC HASIBE The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. , 2021, ss.1905 - 1911. 10.3906/sag-2012-192
AMA	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. . 2021; 1905 - 1911. 10.3906/sag-2012-192
Vancouver	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. . 2021; 1905 - 1911. 10.3906/sag-2012-192
IEEE	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H "The alteration of lymphocyte subsets in idiopathic granulomatous mastitis." , ss.1905 - 1911, 2021. 10.3906/sag-2012-192
ISNAD	Ceylan, Ayca vd. "The alteration of lymphocyte subsets in idiopathic granulomatous mastitis". (2021), 1905-1911. https://doi.org/10.3906/sag-2012-192

APA	Ceylan A, Köksal H, Ozdemir H, Kadoglou N, ARTAC H (2021). The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. Turkish Journal of Medical Sciences, 51(4), 1905 - 1911. 10.3906/sag-2012-192
Chicago	Ceylan Ayca,Köksal Hande,Ozdemir Hulya,Kadoglou Naim,ARTAC HASIBE The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. Turkish Journal of Medical Sciences 51, no.4 (2021): 1905 - 1911. 10.3906/sag-2012-192
MLA	Ceylan Ayca,Köksal Hande,Ozdemir Hulya,Kadoglou Naim,ARTAC HASIBE The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. Turkish Journal of Medical Sciences, vol.51, no.4, 2021, ss.1905 - 1911. 10.3906/sag-2012-192
AMA	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. Turkish Journal of Medical Sciences. 2021; 51(4): 1905 - 1911. 10.3906/sag-2012-192
Vancouver	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H The alteration of lymphocyte subsets in idiopathic granulomatous mastitis. Turkish Journal of Medical Sciences. 2021; 51(4): 1905 - 1911. 10.3906/sag-2012-192
IEEE	Ceylan A,Köksal H,Ozdemir H,Kadoglou N,ARTAC H "The alteration of lymphocyte subsets in idiopathic granulomatous mastitis." Turkish Journal of Medical Sciences, 51, ss.1905 - 1911, 2021. 10.3906/sag-2012-192
ISNAD	Ceylan, Ayca vd. "The alteration of lymphocyte subsets in idiopathic granulomatous mastitis". Turkish Journal of Medical Sciences 51/4 (2021), 1905-1911. https://doi.org/10.3906/sag-2012-192