Özgür ÖCAL
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Ahmet Eren SEÇEN
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Denizhan DİVANLIOĞLU
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Zeynep DAĞLAR
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Göksal GÜNERHAN
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Esra FIRAT OĞUZ
(Ankara Şehir Hastanesi, Biyokimya Kliniği, Ankara, Türkiye)
Özcan EREL
(Ankara Şehir Hastanesi, Biyokimya Kliniği, Ankara, Türkiye)
Ali DALGIÇ
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Yıl: 2021Cilt: 32Sayı: 4ISSN: 2147-5903Sayfa Aralığı: 139 - 143İngilizce

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EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION
Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802- 0.974). Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.
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