Özgür ÖCAL
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Ahmet Eren SEÇEN
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
(Ankara Şehir Hastanesi, Biyokimya Kliniği, Ankara, Türkiye)
Özcan EREL
(Ankara Şehir Hastanesi, Biyokimya Kliniği, Ankara, Türkiye)
(Ankara Şehir Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)
Yıl: 2021Cilt: 32Sayı: 4ISSN: 2147-5903Sayfa Aralığı: 139 - 143İngilizce

0 0
Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802- 0.974). Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.
DergiAraştırma MakalesiErişime Açık
  • 1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis fort he global burden of disease study 2010. Lancet. 2012;380:2163-96.
  • 2. Jordan J, Konstantinou K, O’Dowd J. Herniated lumbar disc. BMJ Clin Evid. 2011;2011:1118.
  • 3. Cong L, Zhu Y and Tu G. A meta-analysis of endoscopic discectomy versus open discectomy for symptomatic lumbar disk herniation. Eur Spine J. 2016;25:134-43.
  • 4. Jha SC, Tonogai I, Takata Y, Sakai T, Higashino K, Matsuura T, et al. Percutaneous endoscopic lumbar discectomy for a huge herniated disc causing acute cauda equina syndrome: A case report. J Med Invest. 2015;62:100-2.
  • 5. Wang SJ, Chen BH, Wang P, Liu CS, Yu JM, Ma XX. The effect of percutaneous endoscopic lumbar discectomy under different anesthesia on pain and immunity of patients with prolapse of lumbar intervertebral disc. Eur Rev Med Pharmacol Sci. 2017;21:2793-9.
  • 6. Hou G, Lu H, Chen M, Yao H, Zhao H. Oxidative stress participates in age-related changes in rat lumbar intervertebral discs. Arch Gerontol Geriatr. 2014;59:665-9.
  • 7. Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: Implications for disc degeneration. Cell Physiol Biochem. 2014;34:1175-89.
  • 8. Wang H, Song Y, Cai L. Effect of percutaneous transforaminal lumbar spine endoscopic discectomy on lumbar disc herniation and its influence on indexes of oxidative stress. Biomed Res. 2017;28:9464-9.
  • 9. Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, et al. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17:316.
  • 10. Dimozi A, Mavrogonatou E, Sklirou A, Kletsas D. Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells. Eur Cell Mater. 2015;30:89-102; discussion 103.
  • 11. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47:326-32.
  • 12. Erol SA, Tanacan A, Altinboga O, Ozturk FH, Ozgu BS, Tasci Y, et al. Evaluation of fetal serum thiol/disulfide homeostasis and ıschemiamodified albumin levels in fetal Distress. Fetal Pediatr Pathol. 2020:1-10.
  • 13. Liu Y, Lin J, Wu X, Guo X, Sun H, Yu B, et al. Aspirin-mediated attenuation of ıntervertebral disc degeneration by ameliorating reactive oxygen species in vivo and in vitro. Oxid Med Cell Longev. 2019;2019:7189854.
  • 14. Siti HN, Kamisah Y, Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascul Pharmacol. 2015;71:40-56.
  • 15. Lakkur S, Judd S, Bostick RM, McClellan W, Flanders WD, Stevens VL, et al. Oxidative stress, inflammation, and markers of cardiovascular health. Atherosclerosis. 2015;243:38-43.
  • 16. Bossola M, Tazza L. Wishful thinking: the surprisingly sparse evidence for a relationship between oxidative stress and cardiovascular disease in hemodialysis patients. Semin Dial. 2015;28:224-30.
  • 17. Guner R, Tasyaran MA, Keske S, Hasanoglu I, Kalem AK, Yapar D, et al. Relationship between total thiol status and thrombocytopenia in patients with Crimean-Congo hemorrhagic fever. Southeast Asian J Trop Med Public Health. 2012;43:1411-8.
  • 18. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37:112-9.
  • 19. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37:277-85.
  • 20. Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW. Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration. Arthritis Res Ther. 2011;13:R215.
  • 21. Chen J, Hous C, Chen X, Wang D, Yang P, He X, et al. Protective effect of cannabidiol on hydrogen peroxide-induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells. Mol Med Rep. 2016;14:2321-7.
  • 22. Holguin N, Silva MJ. In-vivo nucleus pulposus-specific regulation of adult murine intervertebral disc degeneration via wnt/beta-catenin signaling. Sci Rep. 2018;8:11191.
  • 23. Wang Y, Shen J, Chen Y, Liu H, Zhou H, Bai Z, et al. PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun. 2018;504:406-14.
  • 24. Basaran R, Senol M, Ozkanli S, Efendioglu M, Kaner T. Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. J Clin Neurosci. 2017;41:46-49.
  • 25. Gündüztepe Y, Bukan N, Zorlu E, Karaman Y, Andaç Topkan T, Gurbuz N, et al. The evaluation of thiol-disulfite balance, ischemia albumin modification and seruloplazmine as a new oxidative stress in mild cognitive impairment and early stage alzheimer’s disease patients. J Clin Neurosci. 2020;75:188-94.
  • 26. Vural G, Gumusyayla S, Bektas H, Deniz O, Alisik M, Erel O. Impairment of dynamic thiol-disulphide homeostasis in patients with idiopathic Parkinson’s disease and its relationship with clinical stage of disease. Clin Neurol Neurosurg. 2017;153:50-5.
  • 27. Lepetsos P, Papavassiliou AG. ROS/oxidative stress signaling in osteoarthritis. Biochim Biophys Acta. 2016;1862:576-91.
  • 28. Poveda L, Hottiger M, Boos N, Wuertz K. Peroxynitrite induces gene expression in intervertebral disc cells. Spine (Phila Pa 1976). 2009;34:1127-33.
  • 29. Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest. 1997;99:457-68.
  • 30. Nerlich AG, Bachmeier BE, Schleicher E, Rohrbach H, Paesold G, Boos N. Immunomorphological analysis of RAGE receptor expression and NF-kappaB activation in tissue samples from normal and degenerated intervertebral discs of various ages. Ann N Y Acad Sci. 2007;1096:239-48.
  • 31. Nerlich AG, Schleicher ED, Boos N. 1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine (Phila Pa 1976). 1997;22:2781-95.
  • 32. Bahinipati J, Mohapatra PC. Ischemia Modified Albumin as a Marker of Oxidative Stress in Normal Pregnancy. J Clin Diagn Res. 2016;10:BC15-7.
  • 33. Gulpamuk B, Tekin K, Sonmez K, Inanc M, Neselioglu S, Erel O, et al. The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in patients with different stages of diabetes mellitus. Scand J Clin Lab Invest. 2018;78:136-42.
  • 34. Feng C, Yang M, Lan M, Liu C, Zhang Y, Huang B, et al. ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration. Oxid Med Cell Longev. 2017;2017:5601593.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.