Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units

Öz:

Background: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P < .001), lactate level >2 mmol/L (2.78 [1.93-4.01], P < .001), age ≥60 years (2.45 [1.48-4.06)], P < .001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P = .003), vasopressor treatment (1.94 [1.32-2.84], P = .001), positive fluid balance of ≥600 mL/day (1.68 [1.21-2.34], P = .002), PaO2/FiO2 ratio of ≤150 mmHg (1.66 [1.18-2.32], P = .003), and ECOG score ≥1 (1.42 [1.00-2.02], P = .050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Gündoğan K, Akbudak İ, Hancı P, Halacli B, Temel Ş, Gullu Z, İnci K, bilir y, Bozkurt F, yildirim f, ŞİMŞEK M, Yüksel R, Eryilmaz-Eren E, Altintas N, Ferlicolak L, Elay G, Guven G, kara i, AYDIN E, YILMAZ S, Mengi T, SARI S, Akbaş T, Acar Çinleti B, ATES AYHAN N, Ozbek D, Sahin T, açıkgöz a, Esbah A, FIRAT A, Demirer Aydemir F, GURKOK M, Zerman A, Gümüş A, Turkoglu M, AYDOĞDU M, Ulu R, Celik J, balci c, Kirakli C, Karakoc E, OZYILMAZ E, ortaç ersoy n, Öcal S, akın şen i, Tor I, COMERT B, ergan b, Saracoglu K, ergil j, YÜKSEL Ü, tutar n, Sungur M, Topeli A (2021). Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. , 296 - 303.
Chicago	Gündoğan Kürşat,Akbudak İsmail hakkı,Hancı Pervin,Halacli Burcin,Temel Şahin,Gullu Zuhal,İnci Kamil,bilir yeliz,Bozkurt Firdevs Tugba,yildirim fatma,ŞİMŞEK Meltem,Yüksel Recep Civan,Eryilmaz-Eren Esma,Altintas Neriman,Ferlicolak Leyla,Elay Gülseren,Guven Goksel,kara iskender,AYDIN EMRE,YILMAZ SEDA,Mengi Tuğçe,SARI SEMA,Akbaş Türkay,Acar Çinleti Burcu,ATES AYHAN Nazire,Ozbek Deniz Aral,Sahin Taha Koray,açıkgöz aslı,Esbah Ali umit,FIRAT Ahmet,Demirer Aydemir Ferhan,GURKOK MEHMET CAGATAY,Zerman Avşar,Gümüş Ayça,Turkoglu Melda,AYDOĞDU MÜGE,Ulu Ramazan,Celik Jale,balci canan,Kirakli Cenk,Karakoc Emre,OZYILMAZ EZGI,ortaç ersoy nazmiye ebru,Öcal Serpil,akın şen irem,Tor Ibrahim Hakki,COMERT BILGIN,ergan begum,Saracoglu Kemal,ergil julide,YÜKSEL Ümmü Gülsüm,tutar nuri,Sungur Murat,Topeli Arzu Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. (2021): 296 - 303.
MLA	Gündoğan Kürşat,Akbudak İsmail hakkı,Hancı Pervin,Halacli Burcin,Temel Şahin,Gullu Zuhal,İnci Kamil,bilir yeliz,Bozkurt Firdevs Tugba,yildirim fatma,ŞİMŞEK Meltem,Yüksel Recep Civan,Eryilmaz-Eren Esma,Altintas Neriman,Ferlicolak Leyla,Elay Gülseren,Guven Goksel,kara iskender,AYDIN EMRE,YILMAZ SEDA,Mengi Tuğçe,SARI SEMA,Akbaş Türkay,Acar Çinleti Burcu,ATES AYHAN Nazire,Ozbek Deniz Aral,Sahin Taha Koray,açıkgöz aslı,Esbah Ali umit,FIRAT Ahmet,Demirer Aydemir Ferhan,GURKOK MEHMET CAGATAY,Zerman Avşar,Gümüş Ayça,Turkoglu Melda,AYDOĞDU MÜGE,Ulu Ramazan,Celik Jale,balci canan,Kirakli Cenk,Karakoc Emre,OZYILMAZ EZGI,ortaç ersoy nazmiye ebru,Öcal Serpil,akın şen irem,Tor Ibrahim Hakki,COMERT BILGIN,ergan begum,Saracoglu Kemal,ergil julide,YÜKSEL Ümmü Gülsüm,tutar nuri,Sungur Murat,Topeli Arzu Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. , 2021, ss.296 - 303.
AMA	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. . 2021; 296 - 303.
Vancouver	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. . 2021; 296 - 303.
IEEE	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A "Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units." , ss.296 - 303, 2021.
ISNAD	Gündoğan, Kürşat vd. "Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units". (2021), 296-303.

APA	Gündoğan K, Akbudak İ, Hancı P, Halacli B, Temel Ş, Gullu Z, İnci K, bilir y, Bozkurt F, yildirim f, ŞİMŞEK M, Yüksel R, Eryilmaz-Eren E, Altintas N, Ferlicolak L, Elay G, Guven G, kara i, AYDIN E, YILMAZ S, Mengi T, SARI S, Akbaş T, Acar Çinleti B, ATES AYHAN N, Ozbek D, Sahin T, açıkgöz a, Esbah A, FIRAT A, Demirer Aydemir F, GURKOK M, Zerman A, Gümüş A, Turkoglu M, AYDOĞDU M, Ulu R, Celik J, balci c, Kirakli C, Karakoc E, OZYILMAZ E, ortaç ersoy n, Öcal S, akın şen i, Tor I, COMERT B, ergan b, Saracoglu K, ergil j, YÜKSEL Ü, tutar n, Sungur M, Topeli A (2021). Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. Balkan Medical Journal, 38(5), 296 - 303.
Chicago	Gündoğan Kürşat,Akbudak İsmail hakkı,Hancı Pervin,Halacli Burcin,Temel Şahin,Gullu Zuhal,İnci Kamil,bilir yeliz,Bozkurt Firdevs Tugba,yildirim fatma,ŞİMŞEK Meltem,Yüksel Recep Civan,Eryilmaz-Eren Esma,Altintas Neriman,Ferlicolak Leyla,Elay Gülseren,Guven Goksel,kara iskender,AYDIN EMRE,YILMAZ SEDA,Mengi Tuğçe,SARI SEMA,Akbaş Türkay,Acar Çinleti Burcu,ATES AYHAN Nazire,Ozbek Deniz Aral,Sahin Taha Koray,açıkgöz aslı,Esbah Ali umit,FIRAT Ahmet,Demirer Aydemir Ferhan,GURKOK MEHMET CAGATAY,Zerman Avşar,Gümüş Ayça,Turkoglu Melda,AYDOĞDU MÜGE,Ulu Ramazan,Celik Jale,balci canan,Kirakli Cenk,Karakoc Emre,OZYILMAZ EZGI,ortaç ersoy nazmiye ebru,Öcal Serpil,akın şen irem,Tor Ibrahim Hakki,COMERT BILGIN,ergan begum,Saracoglu Kemal,ergil julide,YÜKSEL Ümmü Gülsüm,tutar nuri,Sungur Murat,Topeli Arzu Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. Balkan Medical Journal 38, no.5 (2021): 296 - 303.
MLA	Gündoğan Kürşat,Akbudak İsmail hakkı,Hancı Pervin,Halacli Burcin,Temel Şahin,Gullu Zuhal,İnci Kamil,bilir yeliz,Bozkurt Firdevs Tugba,yildirim fatma,ŞİMŞEK Meltem,Yüksel Recep Civan,Eryilmaz-Eren Esma,Altintas Neriman,Ferlicolak Leyla,Elay Gülseren,Guven Goksel,kara iskender,AYDIN EMRE,YILMAZ SEDA,Mengi Tuğçe,SARI SEMA,Akbaş Türkay,Acar Çinleti Burcu,ATES AYHAN Nazire,Ozbek Deniz Aral,Sahin Taha Koray,açıkgöz aslı,Esbah Ali umit,FIRAT Ahmet,Demirer Aydemir Ferhan,GURKOK MEHMET CAGATAY,Zerman Avşar,Gümüş Ayça,Turkoglu Melda,AYDOĞDU MÜGE,Ulu Ramazan,Celik Jale,balci canan,Kirakli Cenk,Karakoc Emre,OZYILMAZ EZGI,ortaç ersoy nazmiye ebru,Öcal Serpil,akın şen irem,Tor Ibrahim Hakki,COMERT BILGIN,ergan begum,Saracoglu Kemal,ergil julide,YÜKSEL Ümmü Gülsüm,tutar nuri,Sungur Murat,Topeli Arzu Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. Balkan Medical Journal, vol.38, no.5, 2021, ss.296 - 303.
AMA	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. Balkan Medical Journal. 2021; 38(5): 296 - 303.
Vancouver	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units. Balkan Medical Journal. 2021; 38(5): 296 - 303.
IEEE	Gündoğan K,Akbudak İ,Hancı P,Halacli B,Temel Ş,Gullu Z,İnci K,bilir y,Bozkurt F,yildirim f,ŞİMŞEK M,Yüksel R,Eryilmaz-Eren E,Altintas N,Ferlicolak L,Elay G,Guven G,kara i,AYDIN E,YILMAZ S,Mengi T,SARI S,Akbaş T,Acar Çinleti B,ATES AYHAN N,Ozbek D,Sahin T,açıkgöz a,Esbah A,FIRAT A,Demirer Aydemir F,GURKOK M,Zerman A,Gümüş A,Turkoglu M,AYDOĞDU M,Ulu R,Celik J,balci c,Kirakli C,Karakoc E,OZYILMAZ E,ortaç ersoy n,Öcal S,akın şen i,Tor I,COMERT B,ergan b,Saracoglu K,ergil j,YÜKSEL Ü,tutar n,Sungur M,Topeli A "Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units." Balkan Medical Journal, 38, ss.296 - 303, 2021.
ISNAD	Gündoğan, Kürşat vd. "Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units". Balkan Medical Journal 38/5 (2021), 296-303.