A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19

Dastgheib, Seyed Alireza; javaheri, atiyeh; Neamatzadeh, Hossein; Tabatabaiee, Razieh Sadat; Asadian, Fatemeh; Ferdosian, Farzad; karimi zarchi, mojgan; Schwartz, David; Bahrami, Reza

doi:10.4274/tjod.galenos.2021.66750

A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19

Mojgan Karimi-Zarchi, (Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran)

David A. Schwartz, (Department of Pathology, Medical College of Georgia, Augusta, GA, USA)

Reza Bahrami, (Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran)

Seyed Alireza Dastgheib, (Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran)

Atiyeh Javaheri, (Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran)

Razieh Sadat Tabatabaiee, (Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran)

Farzad Ferdosian, (Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran)

Fatemeh Asadian, (Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran)

Hossein Neamatzadeh (Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran)

Turkish Journal of Obstetrics and Gynecology

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Yıl: 2021 Cilt: 18 Sayı: 3 Sayfa Aralığı: 224 - 235 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2021.66750 İndeks Tarihi: 15-01-2022

A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19

Öz:

Preeclampsia and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are both life-threatening disorders when they occur during pregnancy. They are similarly characterized by systemic immune activation and have a deleterious effect on maternal endothelial cells. During the coronavirus disease-2019 (COVID-19) pandemic, there were reports of preeclampsia or a preeclampsia-like syndrome occurring in pregnant women with SARS-CoV-2 infection. We performed a meta-analysis to estimate the risk and prevalence of preeclampsia and SARS-CoV-2 infection in pregnant women. A comprehensive literature search was conducted in PubMed, Web of Science, Scopus, and China National Knowledge Infrastructure to identify all relevant studies published up to February 29, 2020. All studies that reported the prevalence of preeclampsia in pregnant women with SARS-CoV-2 infection were selected. A total of 10 case-control studies and 15 case series met our inclusion criteria. Pooled data revealed no significant difference between infected pregnant women and uninfected pregnant women for the risk of preeclampsia [odds ratio (OR)=1.676, 95% confidence interval (CI) 0.679-4.139, p=0.236]. The stratified analysis revealed significant risk in the infected Asian pregnant women (OR=2.637, 95% CI 1.030-6.747, p=0.043), but not Caucasian. The prevalence of preeclampsia was 8.2% (95% CI 0.057-0.117) in infected pregnant women with COVID-19 in the overall population. Its prevalence was highest in North America (10.7%), followed by Asian (7.9%), Caucasian (6.7%), European (4.9%), and West Asian (2.6%) infected pregnant women. Our pooled data showed that the prevalence of preeclampsia in pregnant women with SARS-CoV-2 infection was 8.2%. However, there was no increased risk of occurrence of preeclampsia among pregnant women with SARS-CoV-2 infection

Anahtar Kelime:

COVID-19’lu gebe kadınlarda preeklampsi riski ve prevalansı: Bir meta-analiz

Öz:

Preeklampsi ve şiddetli akut solunum yolu sendromu koronavirüsü-2 (SARS-CoV-2) enfeksiyonu, gebelikte ortaya çıktıklarında hayatı tehdit eden bozukluklardır. İkisi de benzer şekilde sistemik immün aktivasyon ile karakterizedir ve maternal endotel hücreleri üzerinde zararlı bir etkiye sahiptir. Koronavirüs hastalığı-2019 (COVID-19) pandemisi sırasında, SARS-CoV-2 enfeksiyonu olan hamile kadınlarda preeklampsi veya preeklampsi benzeri bir sendrom oluştuğuna dair raporlar mevcuttur. Burada, hamile kadınlarda preeklampsi ve SARS-CoV-2 enfeksiyonu riskini ve prevalansını tahmin etmek için bir meta-analiz gerçekleştirdik. 30 Şubat 2020’ye kadar yayınlanan tüm ilgili çalışmaları belirlemek için PubMed, Web of Sciences, Scopus ve Çin Ulusal Bilgi Altyapısı’nda kapsamlı bir literatür taraması yapıldı. SARS-CoV-2 enfeksiyonlu hamile kadınlarda preeklampsi prevalansıyla ilgili tüm çalışmalar seçildi. Toplam 10 olgu kontrol çalışması ve 15 olgu serisi dahil etme kriterlerimizi karşıladı. Toplanan veriler, enfekte hamile kadınlar ile enfekte olmayan hamile kadınlar arasında preeklampsi riski açısından anlamlı bir fark olmadığını ortaya koydu [risk oranı (RO=1,676, %95 güven aralığı (GA) 0,679-4,139, p=0,236]. Tabakalı analiz, enfekte Asyalı hamile kadınlarda (RO=2,637, %95 GA 1,030-6,747, p=0,043) anlamlı risk ortaya çıkardı, ancak Kafkasyalılarda bulunmadı. Genel popülasyonda COVID-19 ile enfekte hamile kadınlarda preeklampsi prevalansı %8,2 (%95 GA 0,057-0,117) idi. Prevalans en yüksek Kuzey Amerika’da (%10,7) olup, bunu Asya (%7,9), Kafkasya (%6,7), Avrupa (%4,9) ve Batı Asya (%2,6) izlemekteydi. Birleştirilmiş verilerimiz, SARSCoV-2 enfeksiyonlu gebe kadınlarda preeklampsi prevalansının %8,2 olduğunu gösterdi. Bununla birlikte, SARS-CoV-2 enfeksiyonu olan hamile kadınlar arasında preeklampsi oluşma riskinde artış görülmemiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	karimi zarchi m, Schwartz D, Bahrami R, Dastgheib S, javaheri a, Tabatabaiee R, Ferdosian F, Asadian F, Neamatzadeh H (2021). A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. , 224 - 235. 10.4274/tjod.galenos.2021.66750
Chicago	karimi zarchi mojgan,Schwartz David,Bahrami Reza,Dastgheib Seyed Alireza,javaheri atiyeh,Tabatabaiee Razieh Sadat,Ferdosian Farzad,Asadian Fatemeh,Neamatzadeh Hossein A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. (2021): 224 - 235. 10.4274/tjod.galenos.2021.66750
MLA	karimi zarchi mojgan,Schwartz David,Bahrami Reza,Dastgheib Seyed Alireza,javaheri atiyeh,Tabatabaiee Razieh Sadat,Ferdosian Farzad,Asadian Fatemeh,Neamatzadeh Hossein A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. , 2021, ss.224 - 235. 10.4274/tjod.galenos.2021.66750
AMA	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. . 2021; 224 - 235. 10.4274/tjod.galenos.2021.66750
Vancouver	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. . 2021; 224 - 235. 10.4274/tjod.galenos.2021.66750
IEEE	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H "A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19." , ss.224 - 235, 2021. 10.4274/tjod.galenos.2021.66750
ISNAD	karimi zarchi, mojgan vd. "A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19". (2021), 224-235. https://doi.org/10.4274/tjod.galenos.2021.66750

APA	karimi zarchi m, Schwartz D, Bahrami R, Dastgheib S, javaheri a, Tabatabaiee R, Ferdosian F, Asadian F, Neamatzadeh H (2021). A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. Turkish Journal of Obstetrics and Gynecology, 18(3), 224 - 235. 10.4274/tjod.galenos.2021.66750
Chicago	karimi zarchi mojgan,Schwartz David,Bahrami Reza,Dastgheib Seyed Alireza,javaheri atiyeh,Tabatabaiee Razieh Sadat,Ferdosian Farzad,Asadian Fatemeh,Neamatzadeh Hossein A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. Turkish Journal of Obstetrics and Gynecology 18, no.3 (2021): 224 - 235. 10.4274/tjod.galenos.2021.66750
MLA	karimi zarchi mojgan,Schwartz David,Bahrami Reza,Dastgheib Seyed Alireza,javaheri atiyeh,Tabatabaiee Razieh Sadat,Ferdosian Farzad,Asadian Fatemeh,Neamatzadeh Hossein A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. Turkish Journal of Obstetrics and Gynecology, vol.18, no.3, 2021, ss.224 - 235. 10.4274/tjod.galenos.2021.66750
AMA	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. Turkish Journal of Obstetrics and Gynecology. 2021; 18(3): 224 - 235. 10.4274/tjod.galenos.2021.66750
Vancouver	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19. Turkish Journal of Obstetrics and Gynecology. 2021; 18(3): 224 - 235. 10.4274/tjod.galenos.2021.66750
IEEE	karimi zarchi m,Schwartz D,Bahrami R,Dastgheib S,javaheri a,Tabatabaiee R,Ferdosian F,Asadian F,Neamatzadeh H "A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19." Turkish Journal of Obstetrics and Gynecology, 18, ss.224 - 235, 2021. 10.4274/tjod.galenos.2021.66750
ISNAD	karimi zarchi, mojgan vd. "A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19". Turkish Journal of Obstetrics and Gynecology 18/3 (2021), 224-235. https://doi.org/10.4274/tjod.galenos.2021.66750