Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure

ÇELIKKOL, ALIYE; TÜFEKCİ, SİNAN; KIZILCA, OZGUR; Topçu, Birol

doi:10.4274/BMB.galenos.2021.04.041

Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure

Sinan TÜFEKCİ, (Tekirdağ Namık Kemal Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Bölümü, Neonatoloji Anabilim Dalı, Tekirdağ, Türkiye)

Özgür KIZILCA, (Tekirdağ Namık Kemal Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Bölümü, Çocuk Kardiyolojisi Anabilim Dalı, Tekirdağ, Türkiye)

Aliye ÇELİKKOL, (Tekirdağ Namık Kemal Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Tekirdağ, Türkiye)

Birol TOPÇU (Tekirdağ Namık Kemal Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Tekirdağ, Türkiye)

Bağcılar Tıp Bülteni

3 0

Yıl: 2021 Cilt: 6 Sayı: 3 Sayfa Aralığı: 287 - 294 Metin Dili: İngilizce DOI: 10.4274/BMB.galenos.2021.04.041 İndeks Tarihi: 16-01-2022

Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure

Öz:

Objective: Data on the umbilical cord and postnatal physiological limits of the high sensitivity cardiac troponin T (hs cTnT) in newborns are scarce. This study aims to determine the normal values and upper limits of hs cTnT in healthy newborns. In addition, its clinical significance and usability in neonatal respiratory failure were analyzed. Method: In this non-invasive and retrospective, cross-sectional study, 113 healthy newborns and 93 newborns with non-cardiac respiratory failure, born between July 2018 and January 2020, were evaluated. Hs cTnT was measured in the umbilical cord and 24-96 h after birth in infants. Results: In the healthy group, the median umbilical cord hs cTnT was 38 (17-156) ng/L and 99th percentile hs cTnT was 122 ng/L, and in the respiratory failure group, the median umbilical cord hs cTnT was 72 (27- 326) ng/L. Postnatal day 2-4 median hs cTnT was 75 (10-194) ng/L and 99th percentile value was 194 ng/L in the healthy group, and the median hs cTnT was 145 (41-409) ng/L in the respiratory failure group. The calculated area under the ROC curve for umbilical cord hs cTnT was 0.848 [cut-off: 64, 95% confidence interval (CI): 0.79-0.90, sensitivity: 62.4%, specificity: 93.7%], suggesting that umbilical cord hs cTnT is a sensitive marker for the prediction of neonatal respiratory failure. The calculated area under the ROC curve for control hs cTnT was 0.851 (cut-off: 121.5, 95% CI: 0.79- 0.90, sensitivity: 71%, specificity: 86.8%), suggesting that control hs cTnT is a sensitive marker for the prediction of neonatal respiratory failure. Conclusion: The results show that the reference range of umbilical cord and postnatal hs cTnT in healthy newborns is higher than that in adults. Both hs cTnT values were higher in the neonatal respiratory failure group than those in the healthy group.

Anahtar Kelime:

Sağlıklı Yenidoğanlarda ve Solunum Yetmezliği Olan Yenidoğanlarda Ardışık İki Yüksek Duyarlılıklı Kardiyak Troponin T Ölçümünün Değerlendirilmesi

Öz:

Amaç: Yenidoğanlarda yüksek duyarlılıklı kardiyak Troponin T’nin (hs cTnT) göbek kordonu ve doğum sonrası fizyolojik sınırlarına ilişkin veriler azdır. Bu çalışma sağlıklı yenidoğanlarda hs cTnT’nin normal değerlerini ve üst sınırlarını belirlemeyi amaçlamaktadır. Ayrıca, yenidoğan solunum yetmezliğinde klinik önemi ve kullanılabilirliği analiz edilmiştir. Yöntem: Bu invazif olmayan ve retrospektif, kesitsel çalışmada, Temmuz 2018 ile Ocak 2020 tarihleri arasında doğan 113 sağlıklı yenidoğan ve kalp dışı kaynaklı solunum yetmezliği olan 93 yenidoğan değerlendirildi. Hs cTnT, bebeklerde göbek kordonunda ve doğumdan 24-96 saat sonra ölçüldü. Bulgular: Sağlıklı grupta umbilikal kord hs cTnT medyan 38 (17-156) ng/L; 99. persantil hs cTnT 122 ng/L, solunum yetmezliği grubunda umbilikal kord hs cTnT medyan 72 (27-326) ng/L bulundu. Sağlıklı grupta postnatal 2-4 gün hs cTnT medyan 75 (10-194) ng/L; 99. persantil 194 ng/L, solunum yetmezliği grubunda hs cTnT medyan 145 (41-409) idi. Göbek kordonu için hs cTnT ROC eğrisi eğrinin altındaki alan değeri 0,848 [cut-off 64: %95 güven aralığı (GA): 0,79-0,90, duyarlılık: %62,4, özgüllük: %93,7], göbek kordonu hs cTnT’nin yenidoğan solunum yetmezliğinin tahmini için duyarlı bir belirteç olduğunu düşündürmektedir. Kontrol hs cTnT ROC eğrisi eğrinin altındaki alan değeri 0,851 (cut-off: 121,5, %95 GA: 0,79-0,90, duyarlılık: %71, özgüllük: %86,8), kontrol hs cTnT’nin neonatal solunum yetmezliğinin tahmini için duyarlı bir belirteç olduğunu göstermektedir. Sonuç: Sağlıklı yenidoğanlarda umbilikal kord ve postnatal hs cTnT referans aralığının, erişkin değerlerine göre yüksek olduğu saptanmıştır. Her iki hs cTnT değeri, yenidoğan solunum yetmezliği grubunda sağlıklı gruba göre çok artmıştır

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TÜFEKCİ S, KIZILCA O, ÇELIKKOL A, Topçu B (2021). Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. , 287 - 294. 10.4274/BMB.galenos.2021.04.041
Chicago	TÜFEKCİ SİNAN,KIZILCA OZGUR,ÇELIKKOL ALIYE,Topçu Birol Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. (2021): 287 - 294. 10.4274/BMB.galenos.2021.04.041
MLA	TÜFEKCİ SİNAN,KIZILCA OZGUR,ÇELIKKOL ALIYE,Topçu Birol Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. , 2021, ss.287 - 294. 10.4274/BMB.galenos.2021.04.041
AMA	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. . 2021; 287 - 294. 10.4274/BMB.galenos.2021.04.041
Vancouver	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. . 2021; 287 - 294. 10.4274/BMB.galenos.2021.04.041
IEEE	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B "Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure." , ss.287 - 294, 2021. 10.4274/BMB.galenos.2021.04.041
ISNAD	TÜFEKCİ, SİNAN vd. "Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure". (2021), 287-294. https://doi.org/10.4274/BMB.galenos.2021.04.041

APA	TÜFEKCİ S, KIZILCA O, ÇELIKKOL A, Topçu B (2021). Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. Bağcılar Tıp Bülteni, 6(3), 287 - 294. 10.4274/BMB.galenos.2021.04.041
Chicago	TÜFEKCİ SİNAN,KIZILCA OZGUR,ÇELIKKOL ALIYE,Topçu Birol Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. Bağcılar Tıp Bülteni 6, no.3 (2021): 287 - 294. 10.4274/BMB.galenos.2021.04.041
MLA	TÜFEKCİ SİNAN,KIZILCA OZGUR,ÇELIKKOL ALIYE,Topçu Birol Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. Bağcılar Tıp Bülteni, vol.6, no.3, 2021, ss.287 - 294. 10.4274/BMB.galenos.2021.04.041
AMA	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. Bağcılar Tıp Bülteni. 2021; 6(3): 287 - 294. 10.4274/BMB.galenos.2021.04.041
Vancouver	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure. Bağcılar Tıp Bülteni. 2021; 6(3): 287 - 294. 10.4274/BMB.galenos.2021.04.041
IEEE	TÜFEKCİ S,KIZILCA O,ÇELIKKOL A,Topçu B "Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure." Bağcılar Tıp Bülteni, 6, ss.287 - 294, 2021. 10.4274/BMB.galenos.2021.04.041
ISNAD	TÜFEKCİ, SİNAN vd. "Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure". Bağcılar Tıp Bülteni 6/3 (2021), 287-294. https://doi.org/10.4274/BMB.galenos.2021.04.041