The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

TEKIN, GORKEM; Dereci, Ömür; KOŞAR, Yasin Çağlar

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

Ömür Dereci, (Eskişehir Osmangazi Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı, Eskişehir, Türkiye)

Görkem Tekin, (Eskişehir Osmangazi Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı, Eskişehir, Türkiye)

Yasin Çağlar Koşar (Özel Muayenehane, Ağız, Diş ve Çene Cerrahı, Eskişehir, Türkiye)

International Dental Research

10 1

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 6 - 11 Metin Dili: İngilizce İndeks Tarihi: 17-01-2022

The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

Öz:

Aim: The aim of this study was to compare the efficacy of Alveogyl, 0.8% hyaluronic acid (HA), and 0.2% chlorhexidine digluconate (CHX) gel in reducing pain and improving clinical signs and symptoms of alveolar osteitis. Methodology: The clinical data of patients treated for alveolar osteitis between 01/01/2015 and 01/01/2019 were retrieved for this study. All patients were initially treated by curettage and physiological saline irrigation. Patients were then divided into 4 groups. Group 1 was considered the control group; no other biomaterials were administered after curettage and physiological saline irrigation. All other groups were administered an additional treatment in the socket after curettage and physiological saline irrigation (Group 1 – Alveogyl; Group 2 - 0.8% HA; Group 3 - 0.2% CHX). Patients were evaluated before surgery as well as days 3 and 7 after surgery. The postoperative evaluations included: Visual analog scale (VAS) pain scores, the presence of clinical signs and symptoms of exposed alveolar bone, disorganized blood clots, inflammation around the socket, and bad odor and taste. Results: Sixty-seven patients were included in the study. There was no statistically significant difference between groups in all control evaluations (p>0.05). There was significantly reduced inflammation around the extraction socket on postoperative day 7 in the CHX group compared to that in the control group (p<0.05). No other significant changes in clinical signs and symptoms were observed among groups. Conclusion: There was no significant difference between curettage with physiological saline irrigation alone and the addition of Alveogyl, 0.8% HA, or 0.2% CHX in the reduction of pain in alveolar osteitis. Nonetheless, CHX may reduce inflammation around the extraction sockets.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

1. Daly B, Sharif MO, Newton T, Jones K, Worthington HV: Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev 2012;12:CD006968. (Crossref)
2. Blum IR: Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg 2002;31:309-17. (Crossref)
3. Kolokythas A, Olech E, Miloro M: Alveolar osteitis: a comprehensive review of concepts and controversies. Int J Dent 2010;2010:249073. (Crossref)
4. Field EA, Speechley JA, Rotter E, Scott J: Dry socket incidence compared after a 12 year interval. Br J Oral Maxillofac Surg 1985;23:419-27. (Crossref)
5. Nusair YM, Younis MH: Prevalence, clinical picture, and risk factors of dry socket in a Jordanian dental teaching center. J Contemp Dent Pract 2007;8:53-63. (Crossref)
6. Kaya GŞ, Yapici G, Savaş Z, Güngörmüş M: Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis J Oral Maxillofac Surg 2011;69:1571-7. (Crossref)
7. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA: Intraalveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal 2006;11:E179-84.
8. Trieger N, Schlagel GD: Preventing dry socket. A simple procedure that works. J Am Dent Assoc 1991;122:67-8. (Crossref)
9. Alissa R, Esposito M, Horner K, Oliver R: The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol 2010;3:121-34.
10. Burgoyne CC, Giglio JA, Reese SE, Sima AP, Laskin DM: The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac Surg 2010;68:144-8. (Crossref)
11. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, MagallanesAbad N, Basallote-Gonzalez M, Gutierrez-Perez JL: Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg 2008;66:441-5. (Crossref)
12. Caso A, Hung LK, Beirne OR: Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):155-9. (Crossref)
13. Chen WY, Abatangelo G: Functions of hyaluronan in wound repair. Wound Repair Regen 1999;7:79-89. (Crossref)
14. Soldati D, Rahm F, Pasche P: Mucosal wound healing after nasal surgery. A controlled clinical trial on the efficacy of hyaluronic acid containing cream. Drugs Exp Clin Res 1999;25:253-61.
15. Bergeret-Galley C, Latouche X, Illouz YG: The value of a new filler material in corrective and cosmetic surgery: DermaLive and DermaDeep. Aesthetic Plast Surg 2001;25:249-55. (Crossref)
16. Liguori V, Guillemin C, Pesce GF, Mirimanoff RO, Bernier J: Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 1997;42:155-61. (Crossref)
17. Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA: The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med 2006;35:461- 5. (Crossref)
18. Dubovina D, Mihailović B, Bukumirić Z, Vlahović Z, Miladinović M, Miković N, Lazić Z: The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis. Vojnosanit Pregl 2016;73:1010-5. (Crossref)
19. Afat IM, Akdoğan ET, Gönül O: Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on early soft tissue healing after surgical extraction of impacted mandibular third molars: A prospective clinical study. J Craniomaxillofac Surg 2019;47:280-286. (Crossref)
20. Bayoumi AM, Jan A, Amoudi WA, Shakir M: The Effects of Using Hyaluronic Acid on the Extraction Sockets. Int J Dent Oral Health 2015;2:1-5(Crossref)
21. Guazzo R, Perissinotto E, Mazzoleni S, Ricci S, Peñarrocha-Oltra D, Sivolella S: Effect on wound healing of a topical gel containing amino acid and sodium hyaluronate applied to the alveolar socket after mandibular third molar extraction: A double-blind randomized controlled trial. Quintessence Int 2018;49:831-840.
22. Birn H: Fibrinolytic activity of alveolar bone in "dry socket". Acta Odontol Scand 1972;30:23-32. (Crossref)
23. Faizel S, Thomas S, Yuvaraj V, Prabhu S, Tripathi G: Comparison between neocone, alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. J Maxillofac Oral Surg 2015;14:312- 20. (Crossref)
24. Dutt M: Comparison of efficacy of chlorhexidine digluconate gel and combination of iodoform & butyl paraaminobenzoate in management of dry socket- a clinical study. J Adv Med Dent Scie Res 2018;6:20-22.
25. Chaurasia NK, Upadhyaya C, Dixit S: Comparative Study to Determine the efficacy of Zinc Oxide Eugenol and Alveogyl in Treatment of Dry Socket. Kathmandu Univ Med J (KUMJ) 2017;15:203-206.

APA	Dereci Ö, TEKIN G, KOŞAR Y (2021). The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. , 6 - 11.
Chicago	Dereci Ömür,TEKIN GORKEM,KOŞAR Yasin Çağlar The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. (2021): 6 - 11.
MLA	Dereci Ömür,TEKIN GORKEM,KOŞAR Yasin Çağlar The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. , 2021, ss.6 - 11.
AMA	Dereci Ö,TEKIN G,KOŞAR Y The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. . 2021; 6 - 11.
Vancouver	Dereci Ö,TEKIN G,KOŞAR Y The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. . 2021; 6 - 11.
IEEE	Dereci Ö,TEKIN G,KOŞAR Y "The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis." , ss.6 - 11, 2021.
ISNAD	Dereci, Ömür vd. "The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis". (2021), 6-11.

APA	Dereci Ö, TEKIN G, KOŞAR Y (2021). The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. International Dental Research, 11(1), 6 - 11.
Chicago	Dereci Ömür,TEKIN GORKEM,KOŞAR Yasin Çağlar The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. International Dental Research 11, no.1 (2021): 6 - 11.
MLA	Dereci Ömür,TEKIN GORKEM,KOŞAR Yasin Çağlar The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. International Dental Research, vol.11, no.1, 2021, ss.6 - 11.
AMA	Dereci Ö,TEKIN G,KOŞAR Y The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. International Dental Research. 2021; 11(1): 6 - 11.
Vancouver	Dereci Ö,TEKIN G,KOŞAR Y The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. International Dental Research. 2021; 11(1): 6 - 11.
IEEE	Dereci Ö,TEKIN G,KOŞAR Y "The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis." International Dental Research, 11, ss.6 - 11, 2021.
ISNAD	Dereci, Ömür vd. "The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis". International Dental Research 11/1 (2021), 6-11.