Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey

Background/aim: The aim of this study is to assess the efficacy and safety of ruxolitinib in patients with myelofibrosis. Materials and methods: From 15 centers, 176 patients (53.4% male, 46.6% female) were retrospectively evaluated. Results: The median age at ruxolitinib initiation was 62 (28–87) and 100 (56.8%) of all were diagnosed as PMF. Constitutional symptoms were observed in 84.7%. The median initiation dose of ruxolitinib was 30 mg (10–40). Dose change was made in 69 (39.2%) patients. Forty seven (35.6%) and 20 (15.2%) of 132 patients had hematological and nonhematological adverse events, respectively. The mean spleen sizes before and after ruxolitinib treatment were 219.67 ± 46.79 mm versus 199.49 ± 40.95 mm, respectively (p < 0.001). There was no correlation between baseline features and subsequent spleen response. Overall survival at 1-year was 89.5% and the median follow up was 10 (1–55) months. We could not show any relationship between survival and reduction in spleen size (p = 0.73). Conclusion: We found ruxolitinib to be safe, well tolerated, and effective in real-life clinical practice in Turkey. Ruxolitinib dose titration can provide better responses in terms of not only clinical benefit but also for long term of ruxolitinib treatment.Key words: Myelofibrosis, treatment, survival, ruxolitinib, adverse events

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APA	Soyer N, Ali R, TURGUT M, Haznedaroglu I, yilmaz f, ILHAN G, Cömert M, ASLANER AK M, İNCE İ, yavasoglu İ, Gediz F, Sonmez M, Guvenc B, ozet g, Kaya E, vural f, Sahin F, TOBU M, Durusoy R, Saydam G (2021). Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. , 1033 - 1042. 10.3906/sag-1812-70
Chicago	Soyer Nur,Ali Rıdvan,TURGUT Mehmet,Haznedaroglu Ibrahim C.,yilmaz fergun,ILHAN GÜL,Cömert Melda,ASLANER AK Müzeyyen,İNCE İDRİS,yavasoglu İrfan,Gediz Fusun,Sonmez Mehmet,Guvenc Birol,ozet gulsum,Kaya Emin,vural filiz,Sahin Fahri,TOBU Mahmut,Durusoy Raika,Saydam Guray Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. (2021): 1033 - 1042. 10.3906/sag-1812-70
MLA	Soyer Nur,Ali Rıdvan,TURGUT Mehmet,Haznedaroglu Ibrahim C.,yilmaz fergun,ILHAN GÜL,Cömert Melda,ASLANER AK Müzeyyen,İNCE İDRİS,yavasoglu İrfan,Gediz Fusun,Sonmez Mehmet,Guvenc Birol,ozet gulsum,Kaya Emin,vural filiz,Sahin Fahri,TOBU Mahmut,Durusoy Raika,Saydam Guray Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. , 2021, ss.1033 - 1042. 10.3906/sag-1812-70
AMA	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. . 2021; 1033 - 1042. 10.3906/sag-1812-70
Vancouver	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. . 2021; 1033 - 1042. 10.3906/sag-1812-70
IEEE	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G "Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey." , ss.1033 - 1042, 2021. 10.3906/sag-1812-70
ISNAD	Soyer, Nur vd. "Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey". (2021), 1033-1042. https://doi.org/10.3906/sag-1812-70

APA	Soyer N, Ali R, TURGUT M, Haznedaroglu I, yilmaz f, ILHAN G, Cömert M, ASLANER AK M, İNCE İ, yavasoglu İ, Gediz F, Sonmez M, Guvenc B, ozet g, Kaya E, vural f, Sahin F, TOBU M, Durusoy R, Saydam G (2021). Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. Turkish Journal of Medical Sciences, 51(3), 1033 - 1042. 10.3906/sag-1812-70
Chicago	Soyer Nur,Ali Rıdvan,TURGUT Mehmet,Haznedaroglu Ibrahim C.,yilmaz fergun,ILHAN GÜL,Cömert Melda,ASLANER AK Müzeyyen,İNCE İDRİS,yavasoglu İrfan,Gediz Fusun,Sonmez Mehmet,Guvenc Birol,ozet gulsum,Kaya Emin,vural filiz,Sahin Fahri,TOBU Mahmut,Durusoy Raika,Saydam Guray Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. Turkish Journal of Medical Sciences 51, no.3 (2021): 1033 - 1042. 10.3906/sag-1812-70
MLA	Soyer Nur,Ali Rıdvan,TURGUT Mehmet,Haznedaroglu Ibrahim C.,yilmaz fergun,ILHAN GÜL,Cömert Melda,ASLANER AK Müzeyyen,İNCE İDRİS,yavasoglu İrfan,Gediz Fusun,Sonmez Mehmet,Guvenc Birol,ozet gulsum,Kaya Emin,vural filiz,Sahin Fahri,TOBU Mahmut,Durusoy Raika,Saydam Guray Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. Turkish Journal of Medical Sciences, vol.51, no.3, 2021, ss.1033 - 1042. 10.3906/sag-1812-70
AMA	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. Turkish Journal of Medical Sciences. 2021; 51(3): 1033 - 1042. 10.3906/sag-1812-70
Vancouver	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey. Turkish Journal of Medical Sciences. 2021; 51(3): 1033 - 1042. 10.3906/sag-1812-70
IEEE	Soyer N,Ali R,TURGUT M,Haznedaroglu I,yilmaz f,ILHAN G,Cömert M,ASLANER AK M,İNCE İ,yavasoglu İ,Gediz F,Sonmez M,Guvenc B,ozet g,Kaya E,vural f,Sahin F,TOBU M,Durusoy R,Saydam G "Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey." Turkish Journal of Medical Sciences, 51, ss.1033 - 1042, 2021. 10.3906/sag-1812-70
ISNAD	Soyer, Nur vd. "Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in Turkey". Turkish Journal of Medical Sciences 51/3 (2021), 1033-1042. https://doi.org/10.3906/sag-1812-70