Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia
Yıl: 2021 Cilt: 27 Sayı: 2 Sayfa Aralığı: 192 - 194 Metin Dili: İngilizce DOI: 10.4274/tnd.2021.28000 İndeks Tarihi: 19-01-2022
Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia
Öz: Pisa syndrome (PS) has been described for the first time as a side effect of neuroleptic treatment in patients with schizophrenia. After its first description, PS was reported in patients on dopamine receptor antagonists, cholinesterase inhibitors, and antidepressants. PS was also associated with neurodegenerative diseases such as Alzheimer’s disease, multiple system atrophy, and dementia of Lewy bodies (DLB). Dopaminergic treatment in Parkinson’s disease (PD) may also lead to PS in PD patients. Here, we report a patient with probable DLB who developed PS after the initiation of piribedil treatment. After cessation of piribedil, PS disappeared entirely. We want to highlight that PS related to dopaminergic treatment may be reversible, and like other dopamine agonists, piribedil has the potential to cause PS in patients with parkinsonism.
Anahtar Kelime: Lewy Cisimcikli Demans Tanılı Bir Hastada Piribedil ile Tetiklenen Geri Dönüşümlü Pisa Sendromu
Öz: Pisa sendromu (PS) ilk kez şizofrenili hastalarda nöroleptik tedavinin yan etkisi olarak tarif edilmiştir. Zamanla bu postural bozukluk, dopamin reseptör antagonistleri, kolinesteraz inhibitörleri ve antidepresan tedavi alan hastalarda; Alzheimer hastalığı, multi sistem atrofi, Lewy cisimcikli demans (LCD) gibi nörodejeneratif hastalıklarda ve son olarak da dopaminerjik tedavi verilen Parkinson hastalığı (PH) olan hastalarda gösterilmiştir. Bu olgu sunumunda; muhtemel LCD tanısı konan ve piribedil tedavisi başlandıktan sonra PS gelişen bir hasta sunulmuştur. Piribedil kesildikten sonra PS tamamen düzelmiştir. Bu yazıda; dopaminerjik tedavi ile ilişkili PS’nin geri dönüşümlü olabildiğinin ve piribedilin PH’de PS’ye yol açabileceğinin altını çizmek istedik.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Doherty KM, van de Warrenburg BP, Peralta MC, et al. Postural deformities in Parkinson’s disease. Lancet Neurol 2011;10:538-549.
- 2. Ekbom K, Lindholm H, Ljungberg L. New dystonic syndrome associated with butyrophenone therapy. Z Neurol 1972;202:94-103.
- 3. Suzuki T, Matsuzaka H. Drug-induced Pisa syndrome (pleurothotonus): epidemiology and management. CNS Drugs 2002;16:165-174.
- 4. Tinazzi M, Fasano A, Geroin C, et al. Pisa syndrome in Parkinson disease: an observational multicenter Italian study. Neurology 2015;85:1769-1779.
- 5. Tinazzi M, Geroin C, Gandolfi M, et al. Pisa syndrome in Parkinson’s disease: an integrated approach from pathophysiology to management. Mov Disord 2016;31:1785-1795.
- 6. McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology 2017;89:88-100.
- 7. Galati S, Moller JC, Stadler C. Ropinirole-induced Pisa syndrome in Parkinson disease. Clin Neuropharmacol 2014;37:58-59.
- 8. Cannas A, Solla P, Floris G, et al. Reversible Pisa syndrome in patients with Parkinson’s disease on dopaminergic therapy. J Neurol 2009;256:390-395.
- 9. Molloy S, McKeith IG, O’Brien JT, Burn DJ. The role of levodopa in the management of dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 2005;76:1200-1203.
- 10. Castrioto A, Piscicelli C, Perennou D, Krack P, Debu B. The pathogenesis of Pisa syndrome in Parkinson’s disease. Mov Disord 2014;29:1100-1107.
- 11. Vitale C, Marcelli V, Furia T, et al. Vestibular impairment and adaptive postural imbalance in parkinsonian patients with lateral trunk flexion. Mov Disord 2011;26:1458-1463.
- 12. Yokochi F. Lateral flexion in Parkinson’s disease and Pisa syndrome. J Neurol 2006;253(Suppl 7):VII17-VII20.
- 13. Barone P, Santangelo G, Amboni M, Pellecchia MT, Vitale C. Pisa syndrome in Parkinson’s disease and parkinsonism: clinical features, pathophysiology, and treatment. Lancet Neurol 2016;15:1063-1074.
- 14. Smania N, Corato E, Tinazzi M, et al. Effect of balance training on postural instability in patients with idiopathic Parkinson’s disease. Neurorehabil Neural Repair 2010;24:826-834.
- 15. Formaggio E, Masiero S, Volpe D, et al. Lack of inter-muscular coherence of axial muscles in Pisa syndrome. Neurol Sci 2019;40:1465-1468.
| APA | Atmaca M, bilgic b, Hanagasi H (2021). Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. , 192 - 194. 10.4274/tnd.2021.28000 |
| Chicago | Atmaca Murat Mert,bilgic basar,Hanagasi Hasmet Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. (2021): 192 - 194. 10.4274/tnd.2021.28000 |
| MLA | Atmaca Murat Mert,bilgic basar,Hanagasi Hasmet Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. , 2021, ss.192 - 194. 10.4274/tnd.2021.28000 |
| AMA | Atmaca M,bilgic b,Hanagasi H Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. . 2021; 192 - 194. 10.4274/tnd.2021.28000 |
| Vancouver | Atmaca M,bilgic b,Hanagasi H Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. . 2021; 192 - 194. 10.4274/tnd.2021.28000 |
| IEEE | Atmaca M,bilgic b,Hanagasi H "Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia." , ss.192 - 194, 2021. 10.4274/tnd.2021.28000 |
| ISNAD | Atmaca, Murat Mert vd. "Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia". (2021), 192-194. https://doi.org/10.4274/tnd.2021.28000 |
| APA | Atmaca M, bilgic b, Hanagasi H (2021). Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. Türk Nöroloji Dergisi, 27(2), 192 - 194. 10.4274/tnd.2021.28000 |
| Chicago | Atmaca Murat Mert,bilgic basar,Hanagasi Hasmet Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. Türk Nöroloji Dergisi 27, no.2 (2021): 192 - 194. 10.4274/tnd.2021.28000 |
| MLA | Atmaca Murat Mert,bilgic basar,Hanagasi Hasmet Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. Türk Nöroloji Dergisi, vol.27, no.2, 2021, ss.192 - 194. 10.4274/tnd.2021.28000 |
| AMA | Atmaca M,bilgic b,Hanagasi H Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. Türk Nöroloji Dergisi. 2021; 27(2): 192 - 194. 10.4274/tnd.2021.28000 |
| Vancouver | Atmaca M,bilgic b,Hanagasi H Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia. Türk Nöroloji Dergisi. 2021; 27(2): 192 - 194. 10.4274/tnd.2021.28000 |
| IEEE | Atmaca M,bilgic b,Hanagasi H "Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia." Türk Nöroloji Dergisi, 27, ss.192 - 194, 2021. 10.4274/tnd.2021.28000 |
| ISNAD | Atmaca, Murat Mert vd. "Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia". Türk Nöroloji Dergisi 27/2 (2021), 192-194. https://doi.org/10.4274/tnd.2021.28000 |
