Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats

Armağan, Metin; TOK, Olgu Enis; KARA, Mehmet; Ustunova, Savas; Esrefoglu, Mukaddes; Meral, Ismail; ergül erkeç, özlem

Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats

Özlem ERGÜL ERKEÇ, (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Van, Türkiye)

İsmail MERAL, (Bezmialem Vakıf Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, İstanbul. Türkiye)

Mehmet KARA, (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Van. Türkiye)

Mukaddes EŞREFOĞLU, (Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul. Türkiye)

Savaş ÜSTÜNOVA, (Bezmialem Vakıf Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, İstanbul. Türkiye)

Olgu Enis TOK, (İstanbul Medipol Üniversitesi, Histoloji ve Embriyoloji Anabilim Dalı, Rejeneratif ve Restoratif Tıp Araştırma Merkezi, İstanbul. Türkiye)

Metin ARMAĞAN (Aydın Adnan Menderes Üniversitesi Buharkent Meslek Yüksekokulu, Tıbbi ve Aromatik Bitkiler Programı, Aydın. Türkiye)

Epilepsi

5 0

Yıl: 2021 Cilt: 27 Sayı: 3 Sayfa Aralığı: 131 - 137 Metin Dili: İngilizce İndeks Tarihi: 17-02-2022

Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats

Öz:

Objectives: This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling. Methods: The rats were divided into three groups: Control group, pentylenetetrazol administered (PTZ) group, and PTZ+CI extract administered (PTZ+CI) group. Control group received only physiological saline (0.5 ml). PTZ (35 mg/kg) injected to the animals in the PTZ and PTZ+CI groups. The CI extract (200 mg/kg) was also administered to the PTZ+CI group. A 75 mg/kg challenge dose of PTZ was administrated to the PTZ treated groups, on the 12th injection. Results: A significant increase was found in the number of neurons expressing the GABAA receptor in the brain tissue (hippocampus and cerebral cortex) of the PTZ group when compared to the control. The density of GABAA receptor of the neurons in the cerebral cortex significantly increased in PTZ administered groups compared to the control. The number of apoptotic neurons was found non-significant between groups in the brain. Conclusion: CI treatment prolonged the onset of the first seizure activity and seizure latency at a convulsive dose, and kept the number of GABAA receptors close to that of the control in the hippocampus

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ergül erkeç ö, Meral I, KARA M, Esrefoglu M, Ustunova S, TOK O, Armağan M (2021). Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. , 131 - 137.
Chicago	ergül erkeç özlem,Meral Ismail,KARA Mehmet,Esrefoglu Mukaddes,Ustunova Savas,TOK Olgu Enis,Armağan Metin Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. (2021): 131 - 137.
MLA	ergül erkeç özlem,Meral Ismail,KARA Mehmet,Esrefoglu Mukaddes,Ustunova Savas,TOK Olgu Enis,Armağan Metin Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. , 2021, ss.131 - 137.
AMA	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. . 2021; 131 - 137.
Vancouver	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. . 2021; 131 - 137.
IEEE	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M "Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats." , ss.131 - 137, 2021.
ISNAD	ergül erkeç, özlem vd. "Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats". (2021), 131-137.

APA	ergül erkeç ö, Meral I, KARA M, Esrefoglu M, Ustunova S, TOK O, Armağan M (2021). Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. Epilepsi, 27(3), 131 - 137.
Chicago	ergül erkeç özlem,Meral Ismail,KARA Mehmet,Esrefoglu Mukaddes,Ustunova Savas,TOK Olgu Enis,Armağan Metin Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. Epilepsi 27, no.3 (2021): 131 - 137.
MLA	ergül erkeç özlem,Meral Ismail,KARA Mehmet,Esrefoglu Mukaddes,Ustunova Savas,TOK Olgu Enis,Armağan Metin Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. Epilepsi, vol.27, no.3, 2021, ss.131 - 137.
AMA	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. Epilepsi. 2021; 27(3): 131 - 137.
Vancouver	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats. Epilepsi. 2021; 27(3): 131 - 137.
IEEE	ergül erkeç ö,Meral I,KARA M,Esrefoglu M,Ustunova S,TOK O,Armağan M "Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats." Epilepsi, 27, ss.131 - 137, 2021.
ISNAD	ergül erkeç, özlem vd. "Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats". Epilepsi 27/3 (2021), 131-137.