The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies
Yıl: 2021 Cilt: 27 Sayı: 3 Sayfa Aralığı: 150 - 154 Metin Dili: İngilizce DOI: 10.14744/epilepsi.2021.77699 İndeks Tarihi: 17-02-2022
The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies
Öz: Objectives: What is expected from anti-epileptic treatment is low side effects and drug-drug interactions as well as high efficacy. In this study, the efficacy of lacosamide in polytherapy and its effect on prognosis were evaluated. Methods: Seventy-seven patients with focal epilepsy who were followed up for at least 1 year and using lacosamide were included in the study. The antiepileptic drugs they use, the side effects of the drugs, neuroimaging and electrophysiological examinations were evaluated. Results: A total of 77 patients, including 35 women (44.9%) and 42 men (55.1%), were included in the study. The mean age was 33.9±10.6 (min: 19 max: 67). Average age of seizure onset was 12.6±10.7, and none of the patients were using Lacosamide (LKS) as monotherapy. Although only 3 patients were receiving dual therapy, the remaining 74 patients were receiving 3 or more antiepileptic treatments. While 33 of the patients (42.9%) had a decrease in the frequency of seizures after LKS treatment. Conclusion: Although the percentage of efficacy was obtained as low according to literature information, lacosamide is effective in resistant focal epilepsies with an efficiency of 42.9%. Especially in patients who use drugs other than antiepileptic drugs due to comorbid diseases, the absence of drug-drug interaction and the absence of serious side effects that require termination of treatment may be an indication that it can be used safely.
Anahtar Kelime: Fokal Epilepsilerde Lakozamid Politerapisinin Nöbet Prognozuna Etkisi
Öz: Amaç: Anti epileptik tedaviden beklenenler düşük yan etki ve ilaç-ilaç etkileşimi yanı sıra yüksek etkinliktir. Yan etki ve ilaç-ilaç etkileşiminin düşük olduğu bilinen lakozamidin politerapide etkinliği, prognoz üzerine etkisi değerlendirildi. Gereç ve Yöntem: Çukurova Üniversitesi Tıp Fakültesi Epilepsi polikliniğinde ortalama 2 yıl (min: 1 maks: 3) süre ile takip edilen fokal epilepsi tanısı alan ve lakozamid kullanan 77 hasta çalışmaya dahil edilmiştir. Kullanmakta oldukları antiepileptik ilaçlar (AEİ), yan etkileri, nörogörüntüleme ve elektrofizyolojik incelemeleri değerlendirilmiştir. Bulgular: Otuz beş kadın (%44.9) 42 erkek (%55.1) olmak üzere toplam 77 hasta çalışmaya dahil edildi. Ortalama yaş 33.9±10.6 (min: 19 maks: 67) idi. Ortalama nöbet başlama yaşı 12.6±10.7 olup hastaların hiç biri Lakozamidi (LKS) monoterapi olarak kullanmamaktaydı. Sadece 3 hasta dual terapi almakta olmasına karşın geriye kalan 74 hasta 3’lü veya daha fazla antiepileptik tedavi almaktaydı. Hastaların 33’ünde (%42.9) LKS tedavisi sonrası nöbet sıklığında azalma görülürken 44’ünde nöbet sıklığında değişiklik olmamıştır. Sonuç: Her ne kadar literatür bilgilerine göre etkinlik yüzdesi düşük olarak elde edilmiş olsa da çalışmaya dahil edilen hastalar göz önüne alındığında, %42.9’luk bir etkinlik ile lakozamidin dirençli fokal epilepsilerde etkin olduğunu göstermektedir. Özellikle komorbid hastalığa bağlı AEİ dışında ilaç kullanan olgularda ilaç-ilaç etkileşiminin olmaması ve ciddi ya da tedaviyi sonlandırmayı gerektirecek bir yan etkinin gelişmemesi güvenle kullanılabileceği yönünde bir gösterge olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | peköz m, Bozdemir H, erturk a, Satılmış Ü, Aslan-Kara K (2021). The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. , 150 - 154. 10.14744/epilepsi.2021.77699 |
| Chicago | peköz mehmet taylan,Bozdemir Hacer,erturk ahmet yusuf,Satılmış Ümit,Aslan-Kara Kezban The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. (2021): 150 - 154. 10.14744/epilepsi.2021.77699 |
| MLA | peköz mehmet taylan,Bozdemir Hacer,erturk ahmet yusuf,Satılmış Ümit,Aslan-Kara Kezban The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. , 2021, ss.150 - 154. 10.14744/epilepsi.2021.77699 |
| AMA | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. . 2021; 150 - 154. 10.14744/epilepsi.2021.77699 |
| Vancouver | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. . 2021; 150 - 154. 10.14744/epilepsi.2021.77699 |
| IEEE | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K "The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies." , ss.150 - 154, 2021. 10.14744/epilepsi.2021.77699 |
| ISNAD | peköz, mehmet taylan vd. "The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies". (2021), 150-154. https://doi.org/10.14744/epilepsi.2021.77699 |
| APA | peköz m, Bozdemir H, erturk a, Satılmış Ü, Aslan-Kara K (2021). The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. Epilepsi, 27(3), 150 - 154. 10.14744/epilepsi.2021.77699 |
| Chicago | peköz mehmet taylan,Bozdemir Hacer,erturk ahmet yusuf,Satılmış Ümit,Aslan-Kara Kezban The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. Epilepsi 27, no.3 (2021): 150 - 154. 10.14744/epilepsi.2021.77699 |
| MLA | peköz mehmet taylan,Bozdemir Hacer,erturk ahmet yusuf,Satılmış Ümit,Aslan-Kara Kezban The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. Epilepsi, vol.27, no.3, 2021, ss.150 - 154. 10.14744/epilepsi.2021.77699 |
| AMA | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. Epilepsi. 2021; 27(3): 150 - 154. 10.14744/epilepsi.2021.77699 |
| Vancouver | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies. Epilepsi. 2021; 27(3): 150 - 154. 10.14744/epilepsi.2021.77699 |
| IEEE | peköz m,Bozdemir H,erturk a,Satılmış Ü,Aslan-Kara K "The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies." Epilepsi, 27, ss.150 - 154, 2021. 10.14744/epilepsi.2021.77699 |
| ISNAD | peköz, mehmet taylan vd. "The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies". Epilepsi 27/3 (2021), 150-154. https://doi.org/10.14744/epilepsi.2021.77699 |
