OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING

ŞAHİN KAVAKLI, HAVVA; Kurtoglu Celık, Gulhan; Pamukçu Günaydın, Gül; YILMAZ, MEHMET; Ersen, Teoman; Demir, Bülent; Ergin Tuncay, Merve

doi:10.5505/amj.2021.68335

OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING

Gülhan ÇELİK, (Yıldırım Beyazıt Üniversitesi, Acil Tıp Kliniği, Ankara, Türkiye)

Gül GÜNAYDIN, (Yıldırım Beyazıt Üniversitesi, Acil Tıp Kliniği, Ankara, Türkiye)

Bülent DEMİR, (Manisa Celal Bayar Üniversitesi, Manisa, Türkiye)

Mehmet YILMAZ, (Etimesgut Devlet Hastanesi, Ankara, Türkiye)

Teoman ERSEN, (Sinop Atatürk Devlet Hastanesi, Sinop, Türkiye)

Merve ERGİN, (Yıldırım Beyazıt Üniversitesi, Acil Tıp Kliniği, Ankara, Türkiye)

Havva ŞAHİN KAVAKLI (Yıldırım Beyazıt Üniversitesi, Acil Tıp Kliniği, Ankara, Türkiye)

Ankara Medical Journal

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Yıl: 2021 Cilt: 21 Sayı: 3 Sayfa Aralığı: 428 - 440 Metin Dili: İngilizce DOI: 10.5505/amj.2021.68335 İndeks Tarihi: 18-02-2022

OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING

Öz:

Objectives: Oxidative stress refers to formation of more reactive oxygen species (ROS) than that are eliminated by cellular defense mechanisms (antioxidants). The aim of this study is to determine oxidative stress developed in CO poisoning, to measure oxidant and antioxidant parameters and to study the effects of the NBO and HBO treatments on these parameters. Materials and Methods: On admission to emergency department and at the end of 24th hour after the oxygen therapy, total oxidant status (TOS) was measured as an oxidative stress parameter, total antioxidant status (TAS), paraoxonase (PON), serum paraoxonase (SPON), arylesterase (ARES), and thiol (TTL) levels were measured as indicators of antioxidant capacity. Results: TAS, TTL and ARES levels were found to be significantly lower in the patient group when compared to control group. There were no differences in both inital and 24th hour levels of oxidative stress parameters between the patients who received hyperbaric therapy and normobaric therapy. Conclusion: Continuing decrease of TAS, PON, SPON, ARES, and TTL may be because the antioxidant capacity has not yet been replaced or reperfusion ischemia is caused by treatment. The results of our study support that oxidative balance turns against antioxidants in cases of CO poisoning.

Anahtar Kelime:

KARBON MONOKSİT ZEHİRLENMESİ OLAN HASTALARDA OKSİDATİF STRES

Öz:

Amaç: Oksidatif stres, hücresel savunma mekanizmalarıyla (antioksidanlar) elimine edilenden daha fazla reaktif oksijen türü (ROS) oluşumunu ifade eder. Bu çalışmanın amacı, CO zehirlenmesinde gelişen oksidatif stresi belirlemek, oksidan ve antioksidan parametreleri ölçmek ve normobarik oksijen (NBO9 ve hiperbarik oksijen (HBO) tedavilerinin bu parametreler üzerindeki etkilerini incelemektir. Materyal ve Metot: Acil servise başvuruda ve oksijen tedavisi sonrası 24. saatin sonunda toplam oksidan durum (TOS) oksidatif stres parametresi, total antioksidan durum (TAS), paraoksonaz (PON), serum paraoksonaz (SPON), arilesteraz (ARES) ve tiol (TTL) seviyeleri, antioksidan kapasite göstergesi olarak ölçüldü. Bulgular: Hasta grubunda kontrol grubuna göre TAS, TTL ve ARES düzeyleri anlamlı olarak düşük bulundu. Hiperbarik tedavi ve normobarik tedavi alan hastalar arasında oksidatif stres parametrelerinin hem başlangıç hem de 24. saat düzeylerinde farklılık yoktu. Sonuç: TAS, PON, SPON, ARES ve TTL'de devam eden düşüş, antioksidan kapasitenin henüz değiştirilmemiş olmasından veya reperfüzyon iskemisinin tedaviden kaynaklanmasından kaynaklanıyor olabilir. Çalışmamızın sonuçları CO zehirlenmesi vakalarında oksidatif dengenin antioksidanlara ters döndüğünü desteklemektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kurtoglu Celık G, Pamukçu Günaydın G, Demir B, YILMAZ M, Ersen T, Ergin Tuncay M, ŞAHİN KAVAKLI H (2021). OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. , 428 - 440. 10.5505/amj.2021.68335
Chicago	Kurtoglu Celık Gulhan,Pamukçu Günaydın Gül,Demir Bülent,YILMAZ MEHMET,Ersen Teoman,Ergin Tuncay Merve,ŞAHİN KAVAKLI HAVVA OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. (2021): 428 - 440. 10.5505/amj.2021.68335
MLA	Kurtoglu Celık Gulhan,Pamukçu Günaydın Gül,Demir Bülent,YILMAZ MEHMET,Ersen Teoman,Ergin Tuncay Merve,ŞAHİN KAVAKLI HAVVA OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. , 2021, ss.428 - 440. 10.5505/amj.2021.68335
AMA	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. . 2021; 428 - 440. 10.5505/amj.2021.68335
Vancouver	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. . 2021; 428 - 440. 10.5505/amj.2021.68335
IEEE	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H "OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING." , ss.428 - 440, 2021. 10.5505/amj.2021.68335
ISNAD	Kurtoglu Celık, Gulhan vd. "OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING". (2021), 428-440. https://doi.org/10.5505/amj.2021.68335

APA	Kurtoglu Celık G, Pamukçu Günaydın G, Demir B, YILMAZ M, Ersen T, Ergin Tuncay M, ŞAHİN KAVAKLI H (2021). OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. Ankara Medical Journal, 21(3), 428 - 440. 10.5505/amj.2021.68335
Chicago	Kurtoglu Celık Gulhan,Pamukçu Günaydın Gül,Demir Bülent,YILMAZ MEHMET,Ersen Teoman,Ergin Tuncay Merve,ŞAHİN KAVAKLI HAVVA OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. Ankara Medical Journal 21, no.3 (2021): 428 - 440. 10.5505/amj.2021.68335
MLA	Kurtoglu Celık Gulhan,Pamukçu Günaydın Gül,Demir Bülent,YILMAZ MEHMET,Ersen Teoman,Ergin Tuncay Merve,ŞAHİN KAVAKLI HAVVA OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. Ankara Medical Journal, vol.21, no.3, 2021, ss.428 - 440. 10.5505/amj.2021.68335
AMA	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. Ankara Medical Journal. 2021; 21(3): 428 - 440. 10.5505/amj.2021.68335
Vancouver	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING. Ankara Medical Journal. 2021; 21(3): 428 - 440. 10.5505/amj.2021.68335
IEEE	Kurtoglu Celık G,Pamukçu Günaydın G,Demir B,YILMAZ M,Ersen T,Ergin Tuncay M,ŞAHİN KAVAKLI H "OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING." Ankara Medical Journal, 21, ss.428 - 440, 2021. 10.5505/amj.2021.68335
ISNAD	Kurtoglu Celık, Gulhan vd. "OXIDATIVE STRESS IN PATIENTS WITH CARBON MONOXIDE POISONING". Ankara Medical Journal 21/3 (2021), 428-440. https://doi.org/10.5505/amj.2021.68335