Yıl: 2022 Cilt: 50 Sayı: 1 Sayfa Aralığı: 31 - 36 Metin Dili: İngilizce DOI: 10.15671/hjbc.817435 İndeks Tarihi: 29-07-2022

SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING

Öz:
In this study, the new benzimidazolium salt (1) containing ether functionalized alkyl group as the NHC ligand precursor was synthesized. Ag-NHC complex (2) was synthesized by interaction with Ag2O of this ligand precursor. The Au-NHC complex was synthesized by interaction the [AuCl(PPh3)] complex with the synthesized Ag-NHC complex. The structures of prepared all new compounds were characterized by different spectroscopic methods.
Anahtar Kelime: Benzimidazolium salt N-Heterocyclic carbene gold

Güçlü Metal-Karbon Bağı İçeren Gümüş- ve Altın-N-Heterosiklik Karben Komplekslerinin Sentezi

Öz:
Bu çalışmada, NHC ligand öncüsü olarak eter fonksiyonlu alkil grubu içeren yeni benzimidazol tuzu (1) sentezlendi. Ag− NHC kompleksi (2) bu ligand öncüsünün Ag2 O ile etkileştirilmesiyle sentezlendi. Au−NHC kompleksi (3) sentezlenmiş Ag−NHC kompleksi ile [AuCl(PPh3 )] kompleksinin etkileştirilmesiyle sentezlendi. Hazırlanan tüm yeni bileşiklerin yapısı farklı spektroskopik metodlar ile karakterize edildi.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. X. Hu, I. Castro-Rodriguez, K. Olsen, K. Meyer, Group 11 metal complexes of N-heterocyclic carbene ligands: Nature of the metal carbene bond, Organometallics, 23(4) (2004) 755-764.
  • 2. D. Nemcsok, K. Wichmann, G. Frenking, The significance of π interactions in group 11 complexes with N-heterocyclic carbenes, Organometallics, 23(15) (2004) 3640-3646.
  • 3. S. Patil, A. Deall, B. Gleeson, F. Hackenberg, H. Müller-Bunz, F. Paradisi, M. Tacke, Synthesis, cytotoxicity and antibacterial studies of novel symmetrically and non-symmetrically p-nitrobenzyl-substituted N-heterocyclic carbene silver(I) acetate complexes, Zeitschrift für Anorganische und Allgemeine Chemie, 637(3-4) (2011) 386-396.
  • 4. S.Y. Hussaini, R.A. Haque, M.R. Razali, Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives, Journal of Organometallic Chemistry, 882 (2019) 882:96-111.
  • 5. N.A. Johnson, M.R. Southerland, W.J. Youngs. Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts, Molecules, 22 (2017) 1263-1282.
  • 6. S. Medici, M. Peana, G. Crisponi, V.M. Nurch, JI. Lachowicz, M. Remelli, M.A. Zoroddu, Silver coordination compounds: A new horizon in medicine, Coordination Chemistry Reviews, 327-328 (2016) 349–359.
  • 7. L. Kaps, B. Biersack, H. Müller-Bunz, K. Mahal, J. Münzner, M. Tacke, T. Mueller, R. Schobert, Gold(I)–NHC complexes of antitumoral diarylimidazoles: Structures, cellular uptake routes and anticancer activities, Journal of Inorganic Biochemistry, 1(106) (2012) 52-58.
  • 8. A. Gautier, F. Cisnetti, Advances in metal–carbene complexes as potent anti-cancer agents, Metallomics, 4 (2012) 23-32.
  • 9. L. Oehninger, R. Rubbiani, I. Ott, N-Heterocyclic carbene metal complexes in medicinal chemistry, Dalton Transaction, 42 (2013) 3269-3284.
  • 10. M. Juntti, D. Russel, J. Turnpenny, Evidence, politics and power in public policy for the environment, 12 (2009) 207-215.
  • 11. A.B.G. Lansdown, A review of the use of silver in wound care: facts and fallacies, British Journal of Nursing, 13 (2004) S6.
  • 12. A. Melaiye, W. Youngs, Silver and its application as an antimicrobial agent, Expert Opinion on Therapeutic Patents, 15 (2005) 125-130.
  • 13. E.R. Jamieson, SJ. Lippard, Structure, recognition, and processing of cisplatin DNA adducts, Chemical Reviews. 99 (1999) 2467-2498.
  • 14. G. Chu, Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair, The Journal of Biological Chemistry, 269 (1994) 787-790.
  • 15. C.G. Hartinger, P.J. Dyson, Bioorganometallic chemistry from teaching paradigms to medicinal applications, Chemical Society Reviews, 38 (2009) 391-396. 16. S.P. Fricker, Medical uses of gold compounds: Past, present and future, Gold Bulletin, 29 (1996) 53-60.
  • 17. R.S. Melaiye, A. Simons, F. Milsted, C. Pingitore, C.A. Wesdwmiotis, Tessier, W.J. Youngs, Formation of Water-Soluble Pincer Silver(I)-Carbene Complexes: A Novel Antimicrobial Agent, Journal of Medicinal Chemistry, 47 (2004) 973-977.
APA Kaloğlu N, Özdemir İ (2022). SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. , 31 - 36. 10.15671/hjbc.817435
Chicago Kaloğlu Nazan,Özdemir İsmail SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. (2022): 31 - 36. 10.15671/hjbc.817435
MLA Kaloğlu Nazan,Özdemir İsmail SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. , 2022, ss.31 - 36. 10.15671/hjbc.817435
AMA Kaloğlu N,Özdemir İ SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. . 2022; 31 - 36. 10.15671/hjbc.817435
Vancouver Kaloğlu N,Özdemir İ SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. . 2022; 31 - 36. 10.15671/hjbc.817435
IEEE Kaloğlu N,Özdemir İ "SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING." , ss.31 - 36, 2022. 10.15671/hjbc.817435
ISNAD Kaloğlu, Nazan - Özdemir, İsmail. "SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING". (2022), 31-36. https://doi.org/10.15671/hjbc.817435
APA Kaloğlu N, Özdemir İ (2022). SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. Hacettepe Journal of Biology and Chemistry, 50(1), 31 - 36. 10.15671/hjbc.817435
Chicago Kaloğlu Nazan,Özdemir İsmail SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. Hacettepe Journal of Biology and Chemistry 50, no.1 (2022): 31 - 36. 10.15671/hjbc.817435
MLA Kaloğlu Nazan,Özdemir İsmail SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. Hacettepe Journal of Biology and Chemistry, vol.50, no.1, 2022, ss.31 - 36. 10.15671/hjbc.817435
AMA Kaloğlu N,Özdemir İ SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. Hacettepe Journal of Biology and Chemistry. 2022; 50(1): 31 - 36. 10.15671/hjbc.817435
Vancouver Kaloğlu N,Özdemir İ SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING. Hacettepe Journal of Biology and Chemistry. 2022; 50(1): 31 - 36. 10.15671/hjbc.817435
IEEE Kaloğlu N,Özdemir İ "SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING." Hacettepe Journal of Biology and Chemistry, 50, ss.31 - 36, 2022. 10.15671/hjbc.817435
ISNAD Kaloğlu, Nazan - Özdemir, İsmail. "SYNTHESIS OF SILVER- AND GOLD-N-HETEROCYCLIC CARBENE COMPLEXES INCLUDING STRONG METAL-CARBON BINDING". Hacettepe Journal of Biology and Chemistry 50/1 (2022), 31-36. https://doi.org/10.15671/hjbc.817435