Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial

KAYA, Yeşim; KÖMÜROGLU, Ahmet Ufuk; ALKAN, Özer; YÜKSEK, Esra

doi:10.5152/TurkJOrthod.2021.20049

Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial

Özer Alkan, (Ortodonti Anabilim Dalı, Ankara Yıldırım Beyazıt Üniversitesi Diş Hekimliği Fakültesi, Ankara, Türkiye)

Yeşim Kaya, (Yüzuncu Yıl Üniversitesi Diş Hekimliği Fakültesi Ortodonti Anabilim Dalı, Van, Türkiye)

Esra Yüksek, (Yüzuncu Yıl Üniversitesi Diş Hekimliği Fakültesi Ortodonti Anabilim Dalı, Van, Türkiye)

Ahmet Ufuk Kömüroglu (Sağlık Hizmetleri Meslek Yüksekokulu, Van, Türkiye)

Turkish Journal of Orthodontics

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Yıl: 2021 Cilt: 34 Sayı: 1 Sayfa Aralığı: 26 - 30 Metin Dili: İngilizce DOI: 10.5152/TurkJOrthod.2021.20049 İndeks Tarihi: 23-05-2022

Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial

Öz:

Objective: This study aims to evaluate the effect of low-level laser therapy on peri-miniscrew fluid prostaglandin E2 (PGE2) and sub- stance P (SP) levels during orthodontic treatment. Methods: A total of 15 individuals were included in this study. Miniscrews were inserted to the inter-radicular region of the maxillary right and left second premolar and the first molar teeth, and diode lasers were randomly applied to the right or left side. Irradiation was performed at 940 nm wavelength using a gallium-aluminum-arsenide diode laser with 100 mW power output, 0.125 cm2 spectral area, 8 J/cm2 energy density, and 10 seconds of exposure time. Peri-miniscrew fluid samples were collected on the 1st, 3rd, and 7th days, and PGE2 and SP levels were assessed. For statistical comparison, two-way (factors) analysis of variance with repeated measure- ments on one-factor levels was used at statistical significance (p) of <0.05. Results: PGE2 levels on the 1st, 3rd, and 7th days were 160.64±10.05, 135.17±37.18, and 98.57±22.94, respectively, in the control group and 150.75±9.08, 87.17±40.67, and 78.10±16.50, respectively, in the laser group. SP levels on the 1st, 3rd, and 7th days were 79.90±12.05, 64.61±10.05, and 70.05±9.10, respectively, in the control group and 76.32±11.39, 60.25±9.08, and 65.71±5.59, respec- tively, in the laser group. The differences in PGE2 and SP levels between the laser and control groups were not statistically significant at all time intervals. Conclusion: Low-level laser therapy cannot be recommended as a clinical adjunct therapy to reduce inflammation and pain around the miniscrews

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Schnelle MA, Beck FM, Jaynes RM, Huja SS. A Radiographic evalua- tion of the availability of bone for placement of miniscrews. Angle Orthod 2004; 74: 832-7.
2. Kuroda S, Sugawara Y, Deguchi T, Kyung HM, Takano-Yamamoto T. Clinical use of miniscrew implants as orthodontic anchorage: Suc- cess rates and postoperative discomfort. Am J Orthod Dentofacial Orthop 2007; 131: 9-15. [Crossref]
3. Bittencourt LP, Raymundo MV, Mucha JN. The optimal position for insertion of orthodontic miniscrews. Revista Odonto Ciência 2011; 26: 133-8.
4. Poggio PM, Incorvati C, Velo S, Carano A. ‘’Safe Zones’’: a guide for miniscrew positioning in the maxillary and mandibular arch. Angle Orthod 2006; 76: 191-7.
5. Goymen M, Isman E, Taner L, Kurkcu M. Histomorphometric evalua- tion of the effects of various diode lasers and force levels on ortho- dontic mini screw stability. Photomed Laser Surg 2015; 33: 29-34. [Crossref]
6. Miyawaki S, Koyama I, Inoue M, Mishima K, Sugahara T, Takano-Ya- mamoto T. Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage. Am J Or- thod Dentofacial Orthop 2003; 124: 373-8. [Crossref]
7. Antoszewska J, Papadopoulos MA, Park HS, Ludwig B. Five-year experience with orthodontic miniscrew implants: a retrospective investigation of factors influencing success rates. Am J Orthod Den- tofacial Orthop 2009; 136: 158.E1-158.E10. [Crossref]
8. Osman A, Moneim AA, Harouni NE, Shokry M. Long-term evaluation of the effect of low-level laser therapy on orthodontic miniscrew stability and peri-implant gingival condition: A randomized clinical trial. J World Fed Orthod 2017; 6: 109-4. [Crossref]
9. Garcez AS, Suzuki SS, Martinez EF, Lemini MG, Suzuki H. Effects of low-intensity laser therapy over mini-implants success rate in pigs. Lasers Med Sci 2015; 30: 727-32. [Crossref]
10. Pinheiro AL. Advances and perspectives on tissue repair and heal - ing. Photomed Laser Surg 2009; 27: 833-6. [Crossref]
11. Flieger R, Gedrange T, Grzech Leśniak K, Dominiak M, Matys J. Low-level laser therapy with a 635 nm diodelaser affects orthodon- tic mini-implants stability. A randomized Clinical split-mouth trial. J Clin Med 2019; 9: 112-23. [Crossref]
12. Qamruddin I, Alam MK, Fida M, Khan AG. Effect of a single dose of low-level laser therapy on spontaneous and chewing pain caused by elastomeric separators. Am J Orthod Dentofacial Orthop 2016; 149: 62-6. [Crossref]
13. Almallah MME, Almahdi WH, Hajeer MY. Evaluation of low level la- ser therapy on pain perception following orthodontic elastomeric separation: A randomized conrolled trial. J Clin Diagn Res 2016; 10: 23-8. [Crossref]
14. Intachai I, Krisanaprakornkit S, Kongtawelert P, Ong-chai S, Bura- nastidporn B, Suzuki EY, et al. Chondroitin sulphate (WF6 epitope) levels in peri-miniscrew implant crevicular fluid during orthodontic loading. Eur J Orthod 2010; 32: 60-5. [Crossref]
15. Yanaguizawa MS, Suzuki SS, Martinez EF, Suzuki H, Pelegrin MCJ, Garcez AS. Effects of low-level laser therapy in orthodontic patients on immediate inflammatory response after mini-implants inser - tion: A preliminary report. Photomed Laser Surg 2017; 35: 57-63. [Crossref]
16. McGee JM, Tucci MA, Edmundson TP, Serio CL, Johnson RB. The re- lationship between concentrations of proinflammatory cytokines within gingiva and the adjacent sulcular depth. J Periodontol 1998; 69: 865-71. [Crossref]
17. Dongari-Bagtzoglou AI, Ebersole JL. Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge. J Periodontal Res 1996; 31: 90-8. [Crossref]
18. de Avila ED, de Molon RS, de Godoi Gonçalves DA, Camparis CM. Relationship between levels of neuropeptide Substance P in peri- odontal disease and chronic pain: a literature review. J Investig Clin Dent 2014; 5: 91-7. [Crossref]
19. Omasa S, Motoyoshi M, Arai Y, Ejima K, Shimizu N. Low- level laser therapy enhances the stability of orthodontic mini-implants via bone formation related to BMP-2 expression in a rat model. Pho- tomed Laser Surg 2012; 30: 255-61. [Crossref]
20. Sari E, Uçar C. Interleukin 1beta levels around microscrew implants during orthodontic tooth movement. Angle Orthod 2007; 77: 1073- 8. [Crossref]
21. Aoki A, Mizutani K, Schwarz F, Sculean A, Yukna RA, Takasaki AA, et al. Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000; 68: 217-69. [Crossref]
22. Akyol G, Baser U, Maden I, Kazak Z, Onan U, Tanrikulu-Kucuk S, et al. The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment. J Periodontol 2011; 82:481-88. [Crossref]
23. Cobb CM. Lasers in periodontics: A review of the literature. J Peri- odontol 2006; 77: 545-64. [Crossref]
24. Katsikanis F, Strakas D, Vouros I. The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive in the conventional cause-related treatment of chronic periodontal diseases: a randomized controlled split-mouth clinical trial. Clin Oral Investig 2020; 24: 1821-7. [Crossref]
25. Eslamian L, Borzabadi-Farahani A, Hassanzadeh-Azhiri A, Badiee MR, Fekrazad R. The effect of 810-nm low-level laser therapy on pain caused by elastomeric separators. Lasers Med Sci 2014; 29: 559-64. [Crossref]
26. Abohabib AM, Fayed MM, Labib AH. Effects of low-intensity laser therapy on the stability of orthodontic mini-implants: A randomised controlled clinical trial. J Orthod 2018; 45: 149-56. [Crossref]
27. Hamamcı N, Acun Kaya F, Uysal E, Yokuş B. Identification of interleu- kin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement. Eur J Orthod 2012; 34: 357-61. [Crossref]

APA	ALKAN Ö, KAYA Y, YÜKSEK E, KÖMÜROGLU A (2021). Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. , 26 - 30. 10.5152/TurkJOrthod.2021.20049
Chicago	ALKAN Özer,KAYA Yeşim,YÜKSEK Esra,KÖMÜROGLU Ahmet Ufuk Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. (2021): 26 - 30. 10.5152/TurkJOrthod.2021.20049
MLA	ALKAN Özer,KAYA Yeşim,YÜKSEK Esra,KÖMÜROGLU Ahmet Ufuk Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. , 2021, ss.26 - 30. 10.5152/TurkJOrthod.2021.20049
AMA	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. . 2021; 26 - 30. 10.5152/TurkJOrthod.2021.20049
Vancouver	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. . 2021; 26 - 30. 10.5152/TurkJOrthod.2021.20049
IEEE	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A "Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial." , ss.26 - 30, 2021. 10.5152/TurkJOrthod.2021.20049
ISNAD	ALKAN, Özer vd. "Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial". (2021), 26-30. https://doi.org/10.5152/TurkJOrthod.2021.20049

APA	ALKAN Ö, KAYA Y, YÜKSEK E, KÖMÜROGLU A (2021). Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turkish Journal of Orthodontics, 34(1), 26 - 30. 10.5152/TurkJOrthod.2021.20049
Chicago	ALKAN Özer,KAYA Yeşim,YÜKSEK Esra,KÖMÜROGLU Ahmet Ufuk Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turkish Journal of Orthodontics 34, no.1 (2021): 26 - 30. 10.5152/TurkJOrthod.2021.20049
MLA	ALKAN Özer,KAYA Yeşim,YÜKSEK Esra,KÖMÜROGLU Ahmet Ufuk Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turkish Journal of Orthodontics, vol.34, no.1, 2021, ss.26 - 30. 10.5152/TurkJOrthod.2021.20049
AMA	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turkish Journal of Orthodontics. 2021; 34(1): 26 - 30. 10.5152/TurkJOrthod.2021.20049
Vancouver	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial. Turkish Journal of Orthodontics. 2021; 34(1): 26 - 30. 10.5152/TurkJOrthod.2021.20049
IEEE	ALKAN Ö,KAYA Y,YÜKSEK E,KÖMÜROGLU A "Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial." Turkish Journal of Orthodontics, 34, ss.26 - 30, 2021. 10.5152/TurkJOrthod.2021.20049
ISNAD	ALKAN, Özer vd. "Effect of Low-Level Laser Therapy on Peri-Miniscrew Fluid Prostaglandin E2 and Substance P Levels: A Controlled Clinical Trial". Turkish Journal of Orthodontics 34/1 (2021), 26-30. https://doi.org/10.5152/TurkJOrthod.2021.20049