Objective: Condyloma Akuminata (CA) is most common sexually transmitted viral disease caused by Human Papiloma Virus (HPV). Although there are various methods for the treatment of Condyloma Acuminata, none of them can reach 100% response rate. İn this study, for better response rate and low recurrence, efficacy of ablative liquid nitrogen cryotherapy and electrocautery with surgical excision and recurrence rates were tried to be evaluated. Aim: This studies purpose to evaluate the synergistic effect of surgery with cryotherapy in the treatment of condyloma acuminata. Method: In this retrospective study, patients with a diagnosis of Condyloma Acuminata (localized or spread) who applied to the dermatology clinic and whose lesions extend to the anal denta with the perianal region are evaluated. In addition to small lesions treated with cryotherapy, surgical excisional methods were used in patients larger than 4 cm in size. Result: This study included 57 patients, 33 were female and 24 were male. The average age was 27.2 years. 51 of the patients continued treatment. Cryotherapy was applied to all patients, additional topical imiquimod was applied in 14 patients, and 10 patients underwent surgical electrocauterization, as the lesions extended to the anal dentate and their dimensions were over 4 cm. While recurrence was 24.3% in patients undergoing cryotherapy, this rate was 21.4% in patients undergoing cryotherapy and imiquimod. Five of the patients who underwent surgery developed recurrence at the 3rd month and these patients were taken into surgical treatment again. Recurrence was detected in one patient during follow-up. No serious complications developed in the treatments applied. Conclusion: As a result of our study, it was found that anatomical localization and the size of the lesion were determinant in the treatment of CA and surgery performed in addition to cryotherapy reduced recurrence rates.