Reproductive Functions in Male Patients with Epilepsy
Yıl: 2021 Cilt: 27 Sayı: 4 Sayfa Aralığı: 394 - 400 Metin Dili: İngilizce DOI: 10.4274/tnd.2021.04934 İndeks Tarihi: 18-05-2022
Reproductive Functions in Male Patients with Epilepsy
Öz: Objective: Hormonal changes and abnormalities in reproductive function may occur in patients with epilepsy. This study aimed to investigate the abnormalities in the reproductive functions in male patients with epilepsy under antiepileptic treatment and its negative impact on their children. Materials and Methods: A total of 104 participants were included in the study, wherein 52 were patients and 52 were healthy controls. Medical history and completed neurological examination were performed on all participants. Each participant filled out the International Index of Erectile Function (IIEF) and Beck depression scale. Serum hormones and biochemistry tests were also checked. Electroencephalography that was performed within the last 6 months and cerebral imaging anytime during the follow-up period were retrospectively evaluated. The Statistical Package for the Social Sciences 20.0 program was used for statistical evaluation. Results: The mean age of the male patients with epilepsy was 29.1±5.5 years. The prevalence of erectile dysfunction was 63.5% in male patients with epilepsy, and 40.4% of the patients developed erectile dysfunction after antiepileptic drug use. Patients on polytherapy were found to have a higher risk of depression. Furthermore, patients with intractable seizures were more depressed (p=0.044). Beck scale and IIEF scores negatively affected each other (rs: -0.568). Patients with polytherapy have higher estrogen levels, whereas the luteinizing hormone levels were lower. Congenital malformation percentage is defined by 4.2% in children of male patients with epilepsy. Two of them have atrial septal defects and 1 with foramen ovale. Conclusion: The possibility of congenital malformation and abnormalities in the children of male patients with epilepsy should not be overlooked. Patients and their relatives should be provided with the necessary support and information after careful risk assessment.
Anahtar Kelime: Epilepsi Tanılı Erkek Hastalarda Üreme Fonksiyonları
Öz: Amaç: Epilepsi hastalarında hormonal değişiklikler ve üreme fonksiyonunda anormallikler meydana gelebilmektedir. Bu çalışmanın amacı, antiepileptik tedavi alan epilepsi tanılı erkek hastaların üreme işlevlerindeki anormalliklerin ve bu hastaların çocuklarında olumsuz etkilerinin araştırılmasıdır. Gereç ve Yöntem: Çalışmaya 52 hasta ve 52 sağlıklı kontrol olmak üzere toplam 104 kişi dahil edilmiştir. Tüm katılımcıların tıbbi öyküleri alındı ve nörolojik muayeneleri yapıldı. Çalışmaya katılan her bir kişi Uluslararası Erektil İşlev Formu (IIEF) ve Beck depresyon ölçeğini doldurdu. Serum hormon ve biyokimyasal testleri yapıldı. Son altı ay içerisinde yapılan elektroensefalografi ve takibi süresince herhangi bir zamanda yapılan serebral görüntüleme bulguları retrospektif olarak değerlendirildi. Verilerin istatistiksel analizi için SPSS programı 20.0 sürüm kullanıldı. Bulgular: Erkek epilepsi hastalarının yaş ortalaması 29,1±5,5’ti. Epilepsi tanılı erkek hastalarda erektil disfonksiyon prevalansı %63,5 olarak değerlendirildi. Hastaların %40,4’ünde antiepileptik ilaç tedavisi sonrası erektil disfonksiyon geliştiği saptandı. Politerapi alan hastaların depresyon açısından daha yüksek risk altında olduğu saptandı. Ayrıca, kontrolsüz nöbetleri olan hastaların daha depresif olduğu görüldü (p=0,044). Beck depresyon ölçeği ve IIEF skorlarının ters orantılı olduğu belirlendi (rs: -0,568). Politerapi alan hastalarda östrojen seviyeleri daha yüksek, luteinize edici hormon seviyeleri daha düşüktü. Erkek epilepsi hastalarının çocuklarında konjenital malformasyon oranı %4,2 olarak saptandı. Konjenital malformasyonlardan iki tanesi atriyal septal defekt olup bir tanesi de patent foramen ovale olarak değerlendirildi. Sonuç: Epilepsi tanılı erkek hastaların çocuklarında konjenital malformasyon ve anormallik gelişme olasılığı göz ardı edilmemelidir. Dikkatli bir risk değerlendirmesi sonucunda hasta ve yakınlarına gerekli destek ve bilgi yol gösterici alacaktır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Çubuk C, peköz m, Bozdemir H, Aslan-Kara K (2021). Reproductive Functions in Male Patients with Epilepsy. , 394 - 400. 10.4274/tnd.2021.04934 |
| Chicago | Çubuk Can,peköz mehmet taylan,Bozdemir Hacer,Aslan-Kara Kezban Reproductive Functions in Male Patients with Epilepsy. (2021): 394 - 400. 10.4274/tnd.2021.04934 |
| MLA | Çubuk Can,peköz mehmet taylan,Bozdemir Hacer,Aslan-Kara Kezban Reproductive Functions in Male Patients with Epilepsy. , 2021, ss.394 - 400. 10.4274/tnd.2021.04934 |
| AMA | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K Reproductive Functions in Male Patients with Epilepsy. . 2021; 394 - 400. 10.4274/tnd.2021.04934 |
| Vancouver | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K Reproductive Functions in Male Patients with Epilepsy. . 2021; 394 - 400. 10.4274/tnd.2021.04934 |
| IEEE | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K "Reproductive Functions in Male Patients with Epilepsy." , ss.394 - 400, 2021. 10.4274/tnd.2021.04934 |
| ISNAD | Çubuk, Can vd. "Reproductive Functions in Male Patients with Epilepsy". (2021), 394-400. https://doi.org/10.4274/tnd.2021.04934 |
| APA | Çubuk C, peköz m, Bozdemir H, Aslan-Kara K (2021). Reproductive Functions in Male Patients with Epilepsy. Türk Nöroloji Dergisi, 27(4), 394 - 400. 10.4274/tnd.2021.04934 |
| Chicago | Çubuk Can,peköz mehmet taylan,Bozdemir Hacer,Aslan-Kara Kezban Reproductive Functions in Male Patients with Epilepsy. Türk Nöroloji Dergisi 27, no.4 (2021): 394 - 400. 10.4274/tnd.2021.04934 |
| MLA | Çubuk Can,peköz mehmet taylan,Bozdemir Hacer,Aslan-Kara Kezban Reproductive Functions in Male Patients with Epilepsy. Türk Nöroloji Dergisi, vol.27, no.4, 2021, ss.394 - 400. 10.4274/tnd.2021.04934 |
| AMA | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K Reproductive Functions in Male Patients with Epilepsy. Türk Nöroloji Dergisi. 2021; 27(4): 394 - 400. 10.4274/tnd.2021.04934 |
| Vancouver | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K Reproductive Functions in Male Patients with Epilepsy. Türk Nöroloji Dergisi. 2021; 27(4): 394 - 400. 10.4274/tnd.2021.04934 |
| IEEE | Çubuk C,peköz m,Bozdemir H,Aslan-Kara K "Reproductive Functions in Male Patients with Epilepsy." Türk Nöroloji Dergisi, 27, ss.394 - 400, 2021. 10.4274/tnd.2021.04934 |
| ISNAD | Çubuk, Can vd. "Reproductive Functions in Male Patients with Epilepsy". Türk Nöroloji Dergisi 27/4 (2021), 394-400. https://doi.org/10.4274/tnd.2021.04934 |
