Yıl: 2021 Cilt: 63 Sayı: 1 Sayfa Aralığı: 86 - 94 Metin Dili: İngilizce DOI: 10.24953/turkjped.2021.01.010 İndeks Tarihi: 20-05-2022

Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis

Öz:
Background. Catheter-related bloodstream infection (CRBSI) is one of the most common complications ofcentral lines. Data concerning the effectiveness and safety of antibiotic lock therapy (ALT), especially in pediatrichematology and oncology patients, have not yet reached sufficient levels of evidence. We aimed to share ourcenter’s experience on ALT in pediatric cancer and to investigate the causes of ALT failure. Methods. All cases with CRBSI and treated with ALT administiration in children with cancer between January2015 and May 2019 were reviewed. Patients characteristics, laboratory and clinical findings, treatments, outcomeof ALT, recurrences and reinfections were recorded. Patients with successful and unsuccessful ALT outcomeswere compared in order to identify the risk factors for ALT failure. Results. Sixteen eligible CRBSI treated with adjunctive ALT were identified. The most common pathogens werecoagulase negative staphylococci (8/16, 50%). Treatment failure was observed in 31.2% (5/16). Younger age alonewas an independent risk factor for treatment failure (0.9 vs 6.8 years, p = 0.038). Recurrence and reinfection rateswere 23.1% and 16.7%. Mild bleeding occured in two cases (12.5%) and occlusion causing catheter removal wasseen in one (6.3%).Conclusions. ALT was found to be a safe modality with a success rate of 68.8% in children with cancer at ourcenter and younger age was an independent risk factor for treatment failure. Future studies with larger samplesizes are needed to determine the factors affecting the ALT outcome, especially in childhood malignancies.
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APA Karaoglu Asrak H, Belet N, Tüfekçi Ö, Özlü C, Baysal B, INCE D (2021). Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. , 86 - 94. 10.24953/turkjped.2021.01.010
Chicago Karaoglu Asrak Hatice,Belet Nurşen,Tüfekçi Özlem,Özlü Canan,Baysal Birsen,INCE Dilek Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. (2021): 86 - 94. 10.24953/turkjped.2021.01.010
MLA Karaoglu Asrak Hatice,Belet Nurşen,Tüfekçi Özlem,Özlü Canan,Baysal Birsen,INCE Dilek Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. , 2021, ss.86 - 94. 10.24953/turkjped.2021.01.010
AMA Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. . 2021; 86 - 94. 10.24953/turkjped.2021.01.010
Vancouver Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. . 2021; 86 - 94. 10.24953/turkjped.2021.01.010
IEEE Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D "Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis." , ss.86 - 94, 2021. 10.24953/turkjped.2021.01.010
ISNAD Karaoglu Asrak, Hatice vd. "Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis". (2021), 86-94. https://doi.org/10.24953/turkjped.2021.01.010
APA Karaoglu Asrak H, Belet N, Tüfekçi Ö, Özlü C, Baysal B, INCE D (2021). Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. Turkish Journal of Pediatrics, 63(1), 86 - 94. 10.24953/turkjped.2021.01.010
Chicago Karaoglu Asrak Hatice,Belet Nurşen,Tüfekçi Özlem,Özlü Canan,Baysal Birsen,INCE Dilek Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. Turkish Journal of Pediatrics 63, no.1 (2021): 86 - 94. 10.24953/turkjped.2021.01.010
MLA Karaoglu Asrak Hatice,Belet Nurşen,Tüfekçi Özlem,Özlü Canan,Baysal Birsen,INCE Dilek Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. Turkish Journal of Pediatrics, vol.63, no.1, 2021, ss.86 - 94. 10.24953/turkjped.2021.01.010
AMA Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. Turkish Journal of Pediatrics. 2021; 63(1): 86 - 94. 10.24953/turkjped.2021.01.010
Vancouver Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis. Turkish Journal of Pediatrics. 2021; 63(1): 86 - 94. 10.24953/turkjped.2021.01.010
IEEE Karaoglu Asrak H,Belet N,Tüfekçi Ö,Özlü C,Baysal B,INCE D "Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis." Turkish Journal of Pediatrics, 63, ss.86 - 94, 2021. 10.24953/turkjped.2021.01.010
ISNAD Karaoglu Asrak, Hatice vd. "Investigating the risk factors for antibiotic lock therapyfailure in pediatric cancer: a single center retrospectiveanalysis". Turkish Journal of Pediatrics 63/1 (2021), 86-94. https://doi.org/10.24953/turkjped.2021.01.010