THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL
TACROLIMUS CREAM IN PEDIATRIC VITILIGO

Tas, Betul; ALPER, FATMA SİBEL; Eris, Zahide; Taskin, Banu

THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO

Banu TAŞKIN, (Girilmemişş)

Zahide ERIŞ EKEN, (Gayrettepe Florence Nightingale, Dermatoloji Anabilim Dalı, İstanbul, Türkiye)

Betül TAŞ, (İstanbul Bağcılar Eğitim ve Araştırma Hastanesi, Dermatoloji Anabilim Dalı, İstanbul, Türkiye)

Sibel ALPER (Koç Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, İstanbul, Türkiye)

İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi

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Yıl: 2021 Cilt: 25 Sayı: 4 Sayfa Aralığı: 297 - 302 Metin Dili: İngilizce İndeks Tarihi: 26-05-2022

THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO

Öz:

Introduction: To investigate the clinical efficacy and safety of acombination of monochromatic 308-nm excimer lamp therapy and topical tacrolimus for the treatment of pediatric vitiligo. Materials and Method: A total of 37 vitiligo patches from 20 pediatric patients were included in the study. Treatment consisted of 308-nm excimer light therapy administered twice weekly for a total of 20 sessions with twice daily application of 0.03% tacrolimus cream. Demographic data, past medical history, treated areas, and responses were recorded and evaluated, retrospectively. The treatment areas were grouped as follows: head and neck, trunk, and upper and lower extremities. Treatment responses were clinically rated between 0 and 4 as follows: 0, no pigmentation; 1, 1 to 25% pigmentation; 2, 26 to 50% pigmentation; 3, 51 to 75% pigmentation; and 4, >75% pigmentation. Results:After 20 treatments, ≥ 75%, 51-75%, 26-50%, and 1-25% pigmentation was observed in 24%, 14%, 16%, and 27% of the 37 vitiligo patches, respectively. Tr ansient erythema lasting for less than 24 hours was observed in 19% of the cases. Conclusion: The tacrolimus and 308-nm excimer light therapy combination represent a safe and effective alternative for the treatment of patients with pediatric vitiligo.

Anahtar Kelime:

PEDİATRİK VİTİLİGO HASTALARINDA 308-NM EXCİMER LAMBA VE TOPİKAL TAKROLİMUS KOMBİNASYONUNUN ETKİNLİĞİ

Öz:

Giriş:Çalışmanın amacı pediyatrik vitiligo hastalarında monokromatik 308-nm Excimer lamba ve topical takrolimus kombinasyonunun klinik etkinliğini ve güvenliğini araştırmaktır. Gereç ve Yöntem:Çalışmaya 20 pediatrik hastaya ait 37 vitiligo patch dahil edildi. Lezyonlara günde iki kez takrolimus % 0.03 krem ile haftada iki kez, toplam 20 seans 308 nm excimer ışık tedavisi uygulandı. Hastaların demografik verileri, özgeçmişleri, tedavi yanıtları retrospektif olarak değerlendirildi. Tedavi alanları; baş ve boyun, gövde ve üst ve alt ekstremite olarak gruplandı. Tedavi yanıtları klinik olarak 0 ve 4 arasında; 0, pigmentasyon yok; % 1, 1 ila % 25 pigmentasyon; % 2, 26 ila% 50 pigmentasyon; 3, 51 ila 75% pigmentasyon; ve 4,>% 75 pigmentasyon şeklinde derecelendirildi. Bulgular:37 vitiligo yamasının topical tedavive 20 seans mikrofototerapi sonrasında sırasıyla% 24’ünde ≥% 75,% 14’ünde % 51-75,% 16’sında % 26-50 ve% 27'sinde % 1-25 oranında repigmentasyon gözlendi. Vakaların % 19'unda 24 saatten kısa süren geçici eritem görüldü. Sonuç:Takrolimus krem ve 308-nm excimer ışık tedavisi kombinasyonu, pediyatrik vitiligo hastalarının tedavisi için güvenli ve etkili bir alternatiftir

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Taskin B, Eris Z, Tas B, ALPER F (2021). THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. , 297 - 302.
Chicago	Taskin Banu,Eris Zahide,Tas Betul,ALPER FATMA SİBEL THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. (2021): 297 - 302.
MLA	Taskin Banu,Eris Zahide,Tas Betul,ALPER FATMA SİBEL THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. , 2021, ss.297 - 302.
AMA	Taskin B,Eris Z,Tas B,ALPER F THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. . 2021; 297 - 302.
Vancouver	Taskin B,Eris Z,Tas B,ALPER F THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. . 2021; 297 - 302.
IEEE	Taskin B,Eris Z,Tas B,ALPER F "THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO." , ss.297 - 302, 2021.
ISNAD	Taskin, Banu vd. "THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO". (2021), 297-302.

APA	Taskin B, Eris Z, Tas B, ALPER F (2021). THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, 25(4), 297 - 302.
Chicago	Taskin Banu,Eris Zahide,Tas Betul,ALPER FATMA SİBEL THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 25, no.4 (2021): 297 - 302.
MLA	Taskin Banu,Eris Zahide,Tas Betul,ALPER FATMA SİBEL THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, vol.25, no.4, 2021, ss.297 - 302.
AMA	Taskin B,Eris Z,Tas B,ALPER F THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2021; 25(4): 297 - 302.
Vancouver	Taskin B,Eris Z,Tas B,ALPER F THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2021; 25(4): 297 - 302.
IEEE	Taskin B,Eris Z,Tas B,ALPER F "THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO." İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, 25, ss.297 - 302, 2021.
ISNAD	Taskin, Banu vd. "THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO". İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 25/4 (2021), 297-302.