Castleman Disease: A Multicenter Case Series from Turkey
Yıl: 2022 Cilt: 39 Sayı: 2 Sayfa Aralığı: 130 - 135 Metin Dili: İngilizce DOI: 10.4274/tjh.galenos.2022.2021.0670 İndeks Tarihi: 07-06-2022
Castleman Disease: A Multicenter Case Series from Turkey
Öz: Objective: Castleman disease (CD) is a rare disease also known as
angiofollicular lymph node hyperplasia. The two main histological
subtypes are the hyaline vascular and plasma cell variants. It is further
classified as unicentric CD (UCD) or multicentric CD (MCD) according
to the anatomical distribution of the disease and the number of lymph
nodes involved. The aim of this multicenter study was to evaluate all
cases of CD identified to date in Turkey to set up a national registry to
improve the early recognition, treatment, and follow-up of CD.
Materials and Methods: Both adult (n=130) and pediatric (n=10)
patients with lymph node or involved field biopsy results reported as
CD were included in the study. Patients’ demographic information,
clinical and laboratory characteristics, imaging study results, treatment
strategies, and clinical outcomes were evaluated retrospectively.
Results: A total of 140 patients (69 male and 71 female) with a
diagnosis of UCD (n=73) or MCD (n=67) were included. The mean
age was 39 years in the UCD group and 47 years in the MCD group.
Female patients were more common in the UCD group. The most
common histological subtype was hyaline vascular for both UCD
and MCD patients. Asymptomatic patients were more common in
the UCD group. Anemia, elevations of acute phase reactants, and
hypoalbuminemia were more common in the MCD group. The most
commonly used treatment strategies for UCD were surgical excision,
rituximab, and radiotherapy, respectively. All UCD patients were alive
at a median of 19.5 months of follow-up. The most commonly used
treatment strategies for MCD were methyl prednisolone, R-CHOP,
R-CVP, and rituximab. Thirteen MCD patients had died at a median of
34 months of follow-up.
Conclusion: This study is important in presenting the patient
characteristics and treatment strategies for CD from Turkey, with the
potential of increasing awareness about CD. Treatment data may help
in making decisions, particularly in countries that do not have access
to siltuximab. However, larger prospective studies are needed to make
definitive conclusions.
Anahtar Kelime: Castleman Hastalığı: Türkiye’den Çok Merkezli Bir Olgu Serisi
Öz: Amaç: Anjiyofolliküler lenf nodu hiperplazisi olarak da bilinen
Castleman hastalığı (CH), nadir bir hastalık olup başlıca hiyalin vasküler
ve plazma hücreli olmak üzere 2 histolojik alt tipi vardır. Hastalığın
anatomik yayılımı ve tutulan lenf nodu bölgelerinin sayısına göre
unisentrik (UCH) ya da multisentrik (MCH) olarak sınıflandırılır. Bu
çok merkezli çalışmanın amacı bugüne kadar Türkiye’de tanımlanan
tüm CH olgularını tanımlamak, ulusal bir veri tabanı oluşturarak CH’de
erken tanı, tedavi ve takip sürecine katkı sağlamaktır.
Gereç ve Yöntemler: Çalışmaya lenf nodu ya da tutulan alandan
yapılmış biyopsi sonucu CH olarak rapor edilen hem erişkin
(n=130) hem de pediyatrik (n=10) hastalar dahil edildi. Hastaların
demografik bilgileri, klinik ve laboratuvar özellikleri, görüntüleme
bulguları, aldıkları tedaviler ve tedavi sonuçları geriye dönük olarak
değerlendirildi.
Bulgular: Dahil edilen 140 hastanın 69’u kadın, 71’i erkekti. Yetmiş
üç hasta UCH, 67 hasta MCH olarak sınıflandırılmıştı. Yaş ortalaması
UCH’de 39, MCH’de 47 yıl idi. Kadın hastalar UCH’de daha fazlaydı.
Hem UCH hem de MCH için en sık histolojik alt tip hiyalin vaskülerdi.
Asemptomatik hastalar UCH’de daha fazlaydı. Anemi, akut faz
reaktanı yüksekliği ve hipoalbuminemi MCH’de daha sıktı. UCH’de
en sık uygulanan tedaviler sırasıyla cerrahi eksizyon, rituksimab
ve radyoterapiydi. Median 19,5 aylık takipte tüm UCH’li hastalar
hayattaydı. MCH’de 1. basamak tedaviler metil prednizolon, R-CHOP,
R-CVP ve rituksimab idi. Median 34 aylık takipte 13 MCH’li hasta
kaybedilmişti.
Sonuç: Çalışmamız Türkiye’deki CH hastalarının özellikleri ve tedavi
yaklaşımlarını yansıtması açısından önemli olup hastalıkla ilgili
farkındalığın arttırılması potansiyeline sahiptir. Tedavi verileri özellikle
ülkemizde olduğu gibi siltuksimaba ulaşımı zor olan ülkelerde tedavi
seçimi konusunda fikir verebilir. Kesin sonuçlar çıkarmak için büyük
ölçekli prospektif çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Gündüz E, Kirkizlar H, ÜMİT E, karaman gülsaran s, Ozkocaman V, Özkalemkaş F, candar ö, ELVERDİ T, Kucukyurt S, Paydas S, Ceneli O, KARAKUŞ S, MARAL S, Ekinci O, İpek Y, Kis C, Guven Z, AKDENİZ A, CELKAN T, Eroğlu küçükdiler A, Akgun Cagliyan G, ÖZÇELİK ŞENGÖZ C, Karatas A, BULDUK T, ÖZCAN A, belen f, CANBOLAT A, Kartal I, Ören H, Toret E, Özdemir N, Bakanay S (2022). Castleman Disease: A Multicenter Case Series from Turkey. , 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
Chicago | Gündüz Eren,Kirkizlar Hakki Onur,ÜMİT Elif Gülsüm,karaman gülsaran sedanur,Ozkocaman Vildan,Özkalemkaş Fahir,candar ömer,ELVERDİ TUĞRUL,Kucukyurt Selin,Paydas Semra,Ceneli Ozcan,KARAKUŞ Sema,MARAL SENEM,Ekinci Omer,İpek Yıldız,Kis Cem,Guven Zeynep Tugba,AKDENİZ Aydan,CELKAN TÜLIN TIRAJE,Eroğlu küçükdiler Ayşe hilal,Akgun Cagliyan Gulsum,ÖZÇELİK ŞENGÖZ CEYDA,Karatas Ayse,BULDUK TUBA,ÖZCAN Alper,belen fatma burcu,CANBOLAT Aylin,Kartal Ibrahim,Ören Hale,Toret Ersin,Özdemir Nihal,Bakanay Sule Mine Castleman Disease: A Multicenter Case Series from Turkey. (2022): 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
MLA | Gündüz Eren,Kirkizlar Hakki Onur,ÜMİT Elif Gülsüm,karaman gülsaran sedanur,Ozkocaman Vildan,Özkalemkaş Fahir,candar ömer,ELVERDİ TUĞRUL,Kucukyurt Selin,Paydas Semra,Ceneli Ozcan,KARAKUŞ Sema,MARAL SENEM,Ekinci Omer,İpek Yıldız,Kis Cem,Guven Zeynep Tugba,AKDENİZ Aydan,CELKAN TÜLIN TIRAJE,Eroğlu küçükdiler Ayşe hilal,Akgun Cagliyan Gulsum,ÖZÇELİK ŞENGÖZ CEYDA,Karatas Ayse,BULDUK TUBA,ÖZCAN Alper,belen fatma burcu,CANBOLAT Aylin,Kartal Ibrahim,Ören Hale,Toret Ersin,Özdemir Nihal,Bakanay Sule Mine Castleman Disease: A Multicenter Case Series from Turkey. , 2022, ss.130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
AMA | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S Castleman Disease: A Multicenter Case Series from Turkey. . 2022; 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
Vancouver | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S Castleman Disease: A Multicenter Case Series from Turkey. . 2022; 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
IEEE | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S "Castleman Disease: A Multicenter Case Series from Turkey." , ss.130 - 135, 2022. 10.4274/tjh.galenos.2022.2021.0670 |
ISNAD | Gündüz, Eren vd. "Castleman Disease: A Multicenter Case Series from Turkey". (2022), 130-135. https://doi.org/10.4274/tjh.galenos.2022.2021.0670 |
APA | Gündüz E, Kirkizlar H, ÜMİT E, karaman gülsaran s, Ozkocaman V, Özkalemkaş F, candar ö, ELVERDİ T, Kucukyurt S, Paydas S, Ceneli O, KARAKUŞ S, MARAL S, Ekinci O, İpek Y, Kis C, Guven Z, AKDENİZ A, CELKAN T, Eroğlu küçükdiler A, Akgun Cagliyan G, ÖZÇELİK ŞENGÖZ C, Karatas A, BULDUK T, ÖZCAN A, belen f, CANBOLAT A, Kartal I, Ören H, Toret E, Özdemir N, Bakanay S (2022). Castleman Disease: A Multicenter Case Series from Turkey. Turkish Journal of Hematology, 39(2), 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
Chicago | Gündüz Eren,Kirkizlar Hakki Onur,ÜMİT Elif Gülsüm,karaman gülsaran sedanur,Ozkocaman Vildan,Özkalemkaş Fahir,candar ömer,ELVERDİ TUĞRUL,Kucukyurt Selin,Paydas Semra,Ceneli Ozcan,KARAKUŞ Sema,MARAL SENEM,Ekinci Omer,İpek Yıldız,Kis Cem,Guven Zeynep Tugba,AKDENİZ Aydan,CELKAN TÜLIN TIRAJE,Eroğlu küçükdiler Ayşe hilal,Akgun Cagliyan Gulsum,ÖZÇELİK ŞENGÖZ CEYDA,Karatas Ayse,BULDUK TUBA,ÖZCAN Alper,belen fatma burcu,CANBOLAT Aylin,Kartal Ibrahim,Ören Hale,Toret Ersin,Özdemir Nihal,Bakanay Sule Mine Castleman Disease: A Multicenter Case Series from Turkey. Turkish Journal of Hematology 39, no.2 (2022): 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
MLA | Gündüz Eren,Kirkizlar Hakki Onur,ÜMİT Elif Gülsüm,karaman gülsaran sedanur,Ozkocaman Vildan,Özkalemkaş Fahir,candar ömer,ELVERDİ TUĞRUL,Kucukyurt Selin,Paydas Semra,Ceneli Ozcan,KARAKUŞ Sema,MARAL SENEM,Ekinci Omer,İpek Yıldız,Kis Cem,Guven Zeynep Tugba,AKDENİZ Aydan,CELKAN TÜLIN TIRAJE,Eroğlu küçükdiler Ayşe hilal,Akgun Cagliyan Gulsum,ÖZÇELİK ŞENGÖZ CEYDA,Karatas Ayse,BULDUK TUBA,ÖZCAN Alper,belen fatma burcu,CANBOLAT Aylin,Kartal Ibrahim,Ören Hale,Toret Ersin,Özdemir Nihal,Bakanay Sule Mine Castleman Disease: A Multicenter Case Series from Turkey. Turkish Journal of Hematology, vol.39, no.2, 2022, ss.130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
AMA | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S Castleman Disease: A Multicenter Case Series from Turkey. Turkish Journal of Hematology. 2022; 39(2): 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
Vancouver | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S Castleman Disease: A Multicenter Case Series from Turkey. Turkish Journal of Hematology. 2022; 39(2): 130 - 135. 10.4274/tjh.galenos.2022.2021.0670 |
IEEE | Gündüz E,Kirkizlar H,ÜMİT E,karaman gülsaran s,Ozkocaman V,Özkalemkaş F,candar ö,ELVERDİ T,Kucukyurt S,Paydas S,Ceneli O,KARAKUŞ S,MARAL S,Ekinci O,İpek Y,Kis C,Guven Z,AKDENİZ A,CELKAN T,Eroğlu küçükdiler A,Akgun Cagliyan G,ÖZÇELİK ŞENGÖZ C,Karatas A,BULDUK T,ÖZCAN A,belen f,CANBOLAT A,Kartal I,Ören H,Toret E,Özdemir N,Bakanay S "Castleman Disease: A Multicenter Case Series from Turkey." Turkish Journal of Hematology, 39, ss.130 - 135, 2022. 10.4274/tjh.galenos.2022.2021.0670 |
ISNAD | Gündüz, Eren vd. "Castleman Disease: A Multicenter Case Series from Turkey". Turkish Journal of Hematology 39/2 (2022), 130-135. https://doi.org/10.4274/tjh.galenos.2022.2021.0670 |