Effect of Individualized Progesterone Supplementation for Luteal 
Support in Frozen-Thawed Cycles on Pregnancy Outcomes

Doğan Durdağ, Gülşen; Ozmen, Batuhan; Sonmezer, Meltem; Atabekoğlu, Cem Somer; bektas, gizem; Göktepe, Halime; Şükür, Yavuz Emre; türkyılmaz, esengül; Sönmezer, Murat

doi:10.21613/GORM.2020.1122

Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes

Gülşen Doğan DURDAĞ, (Başkent Üniversitesi, Tıp Fakültesi, Adana Uygulama ve Araştırma Hastane, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adana, Türkiye)

Gizem BEKTAŞ, (Gürgan Kliniği, Ankara, Türkiye)

Esengül TÜRKYILMAZ, (Ankara Şehir Hastanesi, Ankara, Türkiye)

Halime GÖKTEPE, (Konya Eğitim ve Araştırma Hastanesi, Konya, Türkiye)

Meltem SÖNMEZER, (Özel ofis, Ankara, Türkiye)

Yavuz Emre ŞÜKÜR, (Ankara Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Doğum, Ankara, Türkiye)

Batuhan ÖZMEN, (Ankara Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Doğum, Ankara, Türkiye)

Cem Somer ATABEKOĞLU, (Ankara Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Doğum, Ankara, Türkiye)

Murat SONMEZER (Ankara Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Doğum, Ankara, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

5 1

Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 50 - 55 Metin Dili: İngilizce DOI: 10.21613/GORM.2020.1122 İndeks Tarihi: 08-06-2022

Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes

Öz:

OBJECTIVE: In frozen-thawed embryo transfer cycles, preparing a synchronous endometrium for the embryo is essential. The aim of this study is to provide individualized luteal support in hormonally replaced frozen-thawed embryo transfer cycles and to evaluate mid-luteal serum progesterone levels and pregnancy outcomes. STUDY DESIGN: In this prospective cohort study, 30 patients were included in a university hospital in a six month period. Serum progesterone level on embryo transfer day was monitored, and if it was found to be below the lower limits defined by previous studies (10 ng/mL), additional 100 mg intramuscular micronized progesterone was administered once. Mid-luteal progesterone levels and pregnancy outcomes were recorded. RESULTS: There was no significant difference between mid-luteal progesterone levels of the patients whose transfer day progesterone was above and below 10 ng/mL (p=0.481). Although the clinical pregnancy rate tended to be higher in patients whose mid-luteal progesterone was above 10 ng/mL, it was also not statistically significant. CONCLUSION: This is the first study in which vaginal progesterone treatment was supported by intramuscular progesterone according to serum progesterone values for the purpose of individualized progesterone support. A significant difference was not found in pregnancy outcomes. However, further studies are required to optimize management and improve pregnancy rates in hormonally treated frozen-thawed embryo transfer cycles.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Doğan Durdağ G, bektas g, türkyılmaz e, Göktepe H, Sonmezer M, Şükür Y, Ozmen B, Atabekoğlu C, Sönmezer M (2022). Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. , 50 - 55. 10.21613/GORM.2020.1122
Chicago	Doğan Durdağ Gülşen,bektas gizem,türkyılmaz esengül,Göktepe Halime,Sonmezer Meltem,Şükür Yavuz Emre,Ozmen Batuhan,Atabekoğlu Cem Somer,Sönmezer Murat Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. (2022): 50 - 55. 10.21613/GORM.2020.1122
MLA	Doğan Durdağ Gülşen,bektas gizem,türkyılmaz esengül,Göktepe Halime,Sonmezer Meltem,Şükür Yavuz Emre,Ozmen Batuhan,Atabekoğlu Cem Somer,Sönmezer Murat Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. , 2022, ss.50 - 55. 10.21613/GORM.2020.1122
AMA	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. . 2022; 50 - 55. 10.21613/GORM.2020.1122
Vancouver	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. . 2022; 50 - 55. 10.21613/GORM.2020.1122
IEEE	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M "Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes." , ss.50 - 55, 2022. 10.21613/GORM.2020.1122
ISNAD	Doğan Durdağ, Gülşen vd. "Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes". (2022), 50-55. https://doi.org/10.21613/GORM.2020.1122

APA	Doğan Durdağ G, bektas g, türkyılmaz e, Göktepe H, Sonmezer M, Şükür Y, Ozmen B, Atabekoğlu C, Sönmezer M (2022). Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. GORM:Gynecology Obstetrics & Reproductive Medicine, 28(1), 50 - 55. 10.21613/GORM.2020.1122
Chicago	Doğan Durdağ Gülşen,bektas gizem,türkyılmaz esengül,Göktepe Halime,Sonmezer Meltem,Şükür Yavuz Emre,Ozmen Batuhan,Atabekoğlu Cem Somer,Sönmezer Murat Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. GORM:Gynecology Obstetrics & Reproductive Medicine 28, no.1 (2022): 50 - 55. 10.21613/GORM.2020.1122
MLA	Doğan Durdağ Gülşen,bektas gizem,türkyılmaz esengül,Göktepe Halime,Sonmezer Meltem,Şükür Yavuz Emre,Ozmen Batuhan,Atabekoğlu Cem Somer,Sönmezer Murat Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.28, no.1, 2022, ss.50 - 55. 10.21613/GORM.2020.1122
AMA	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. GORM:Gynecology Obstetrics & Reproductive Medicine. 2022; 28(1): 50 - 55. 10.21613/GORM.2020.1122
Vancouver	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes. GORM:Gynecology Obstetrics & Reproductive Medicine. 2022; 28(1): 50 - 55. 10.21613/GORM.2020.1122
IEEE	Doğan Durdağ G,bektas g,türkyılmaz e,Göktepe H,Sonmezer M,Şükür Y,Ozmen B,Atabekoğlu C,Sönmezer M "Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes." GORM:Gynecology Obstetrics & Reproductive Medicine, 28, ss.50 - 55, 2022. 10.21613/GORM.2020.1122
ISNAD	Doğan Durdağ, Gülşen vd. "Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes". GORM:Gynecology Obstetrics & Reproductive Medicine 28/1 (2022), 50-55. https://doi.org/10.21613/GORM.2020.1122