Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer
Yıl: 2021 Cilt: 36 Sayı: 4 Sayfa Aralığı: 489 - 496 Metin Dili: İngilizce DOI: 10.5505/tjo.2021.2830 İndeks Tarihi: 15-06-2022
Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer
Öz: OBJECTIVE
Prostate cancer is one of the most common cancers in male gender. Despite recent advances in the
diagnosis and the treatment methods, more reliable molecular biomarkers have been needed for the diagnosis and evaluation of response to treatments such as chemotherapy, anti-androgen therapy, and radiotherapy. The aim of this study is to investigate promoter methylation status of HOX3D and PCDH17
genes in prostate cancer in Turkish population.
METHODS
A total of 46 patients with prostate cancer were included in this study. Tissue samples obtained from
36 patients with benign prostate hyperplasia were used as controls. Methylation status of HOXD3 and
PCDH17 genes was determined by quantitative Methylation-Specific PCR with commercially available
primer sets.
RESULTS
Both HOXD3 and PCDH17 promoter methylation was determined significantly higher in patients
with compare to controls (p=0.0198 and p=0.0386, respectively). A significant but weak correlation
was found between methylation status and pre-operative PSA level for HOXD3 (Spearman’s rho=0.259,
p=0.02) and PCDH17 gene (Spearman’s rho=0.324, p=0.006).
CONCLUSION
Our results indicated that HOXD3 and PCDH17 promoter methylation levels are higher in patients with
prostate cancer. Further studies with large sample cohorts and clinicopathological data will enlighten
presumptive role of HOXD3 and PCDH17 methylation status.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | YÜCEL B, kaya i, Efiloğlu Ö, Karaman A, Bayrak A, İKİIŞIK H, Yildirim A, DEMİRCAN B (2021). Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. , 489 - 496. 10.5505/tjo.2021.2830 |
| Chicago | YÜCEL Burcu,kaya ibrahim alper,Efiloğlu Özgür,Karaman Aslı,Bayrak Ahsen Merve,İKİIŞIK Hatice,Yildirim Asif,DEMİRCAN Berna Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. (2021): 489 - 496. 10.5505/tjo.2021.2830 |
| MLA | YÜCEL Burcu,kaya ibrahim alper,Efiloğlu Özgür,Karaman Aslı,Bayrak Ahsen Merve,İKİIŞIK Hatice,Yildirim Asif,DEMİRCAN Berna Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. , 2021, ss.489 - 496. 10.5505/tjo.2021.2830 |
| AMA | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. . 2021; 489 - 496. 10.5505/tjo.2021.2830 |
| Vancouver | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. . 2021; 489 - 496. 10.5505/tjo.2021.2830 |
| IEEE | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B "Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer." , ss.489 - 496, 2021. 10.5505/tjo.2021.2830 |
| ISNAD | YÜCEL, Burcu vd. "Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer". (2021), 489-496. https://doi.org/10.5505/tjo.2021.2830 |
| APA | YÜCEL B, kaya i, Efiloğlu Ö, Karaman A, Bayrak A, İKİIŞIK H, Yildirim A, DEMİRCAN B (2021). Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. Türk Onkoloji Dergisi, 36(4), 489 - 496. 10.5505/tjo.2021.2830 |
| Chicago | YÜCEL Burcu,kaya ibrahim alper,Efiloğlu Özgür,Karaman Aslı,Bayrak Ahsen Merve,İKİIŞIK Hatice,Yildirim Asif,DEMİRCAN Berna Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. Türk Onkoloji Dergisi 36, no.4 (2021): 489 - 496. 10.5505/tjo.2021.2830 |
| MLA | YÜCEL Burcu,kaya ibrahim alper,Efiloğlu Özgür,Karaman Aslı,Bayrak Ahsen Merve,İKİIŞIK Hatice,Yildirim Asif,DEMİRCAN Berna Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. Türk Onkoloji Dergisi, vol.36, no.4, 2021, ss.489 - 496. 10.5505/tjo.2021.2830 |
| AMA | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. Türk Onkoloji Dergisi. 2021; 36(4): 489 - 496. 10.5505/tjo.2021.2830 |
| Vancouver | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer. Türk Onkoloji Dergisi. 2021; 36(4): 489 - 496. 10.5505/tjo.2021.2830 |
| IEEE | YÜCEL B,kaya i,Efiloğlu Ö,Karaman A,Bayrak A,İKİIŞIK H,Yildirim A,DEMİRCAN B "Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer." Türk Onkoloji Dergisi, 36, ss.489 - 496, 2021. 10.5505/tjo.2021.2830 |
| ISNAD | YÜCEL, Burcu vd. "Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer". Türk Onkoloji Dergisi 36/4 (2021), 489-496. https://doi.org/10.5505/tjo.2021.2830 |
