Correlation between serum uric acid, C-reactive protein, and
neutrophil-to-lymphocyte ratio in patients with psoriasis:
A case-control study

KADNUR, Manjunath; JARTARKAR, Shishira R.; KELOJİ, Hanumanthayya; MİSHRA, Swayamsidda; AGARWAL, Ritu; BABU, Spoorthy

doi:10.4274/turkderm.galenos.2021.69797

Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study

Swayamsidda Mishra, (Vaccicare Clinic, Department of Dermatology, Cuttack, India)

Manjunath Kadnur, (Vydehi Institute of Medical Sciences and Research Center, Department of Dermatology, Venereology and Leprosy, Bangalore, India)

Shishira R. Jartarkar, (Vydehi Institute of Medical Sciences and Research Center, Department of Dermatology, Venereology and Leprosy, Bangalore, India)

Hanumanthayya Keloji, (Sri Devaraj Urs Medical College, Department of Dermatology, Venereology and Leprosy, Kolar, India)

Ritu Agarwal, (Kaya Skin Clinic, Department of Dermatology, Mumbai, India)

Spoorthy Babu (Vydehi Institute of Medical Sciences and Research Center, Department of Dermatology, Venereology and Leprosy, Bangalore, olar, India)

Türkderm Türk deri hastalıkları ve frengi arşivi

12 4

Yıl: 2022 Cilt: 56 Sayı: 1 Sayfa Aralığı: 28 - 33 Metin Dili: İngilizce DOI: 10.4274/turkderm.galenos.2021.69797 İndeks Tarihi: 16-06-2022

Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study

Öz:

Background and Design: Although multiple investigations have been conducted to identify important serum biomarkers in patients with psoriasis, no simple, useful biomarker that could be specific for psoriasis has been identified. Objectives: 1) To determine the levels of serum uric acid (SUA), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) among individuals with psoriasis and controls, 2) to assess the correlation of SUA and CRP levels and NLR with disease severity calculated through the psoriasis area severity index (PASI) in patients with psoriasis. Materials and Methods: A hospital-based, case-control study included 45 patients clinically diagnosed with psoriasis and 45 age- and sex- matched controls attending the outpatient dermatology clinic of our hospital. After a complete history was taken, and general, systemic, and cutaneous examinations were performed, all the cases were subjected to the following investigations: Complete blood count (NLR), CRP, and SUA. Results: Mean SUA level was significantly higher in the patients with psoriasis compared to the controls (p<0.01). However, no difference in CRP levels and NLR was observed (p>0.05). A significant correlation of SUA level and NLR was found with disease severity in the patients with psoriasis as determined by the PASI. In multivariate analysis, only SUA was found to be independently associated with psoriasis severity (p<0.05). Conclusion: The results showed that only SUA to be independently associated with psoriasis severity. No association was found between CRP levels and NLR and disease severity, as well as no difference between the disease and controls groups.

Anahtar Kelime:

Serum ürik asit, C-reaktif protein ve nötrofil/lenfosit oranının psoriazis ile ilişkisi: Bir olgu kontrol çalışması

Öz:

Amaç: Psoriazisli hastaların periferik kan örneklerinde yararlı biyobelirteçler bulmak amacıyla çok sayıda araştırma yapılmış olmasına rağmen, psoriazise özgü olabilecek basit ve klinik olarak yararlı bir biyobelirteç tanımlanmamıştır. Hedefler: 1) Psoriazisli hastalar ve kontroller arasında serum ürik asit (SÜA), C-reaktif protein (CRP) ve nötrofil/lenfosit oranını (NLO) belirlemek, 2) psoriazisi olan hastalarda SÜA seviyeleri, CRP, nötrofil/lenfosit oranı ve psoriazis alan şiddet indeksi (PAŞİ) ile hesaplanan hastalık şiddeti arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: Hastane bazlı bir olgu kontrol çalışmasına, hastanemizin dermatoloji polikliniğine başvuran, klinik olarak teşhis edilmiş 45 psoriazis olgusu, 45 yaş ve cinsiyet uyumlu kontrol dahil edilmiştir. Tam öykü, genel, sistemik ve kutanöz muayeneleri yapıldıktan sonra tüm olgularda tam kan sayımı (NLO), CRP ve SÜA incelemeleri yapılmBulgular: Psoriazis olguları arasında ortalama SÜA düzeyi kontrollere göre anlamlı derecede yüksekti (p<0,01). Ancak CRP düzeyleri ve NLO arasında fark gözlenmedi (p>0,05). Psoriazisli hastalarda SÜA ve NLO ile, PAŞİ skoru ile belirlenen hastalık şiddeti arasında anlamlı bir korelasyon gözlendi. Çok değişkenli analizde, sadece SÜA’nın, psoriazis şiddeti ile bağımsız olarak bir ilişki gösterdiği belirlendi (p<0,05). Sonuç: Bu çalışmanın sonuçları, yalnızca SÜA’nın bağımsız olarak psoriazis şiddeti ile ilişkili olduğunu gösterdi. CRP seviyeleri ile NLO ve hastalık şiddeti arasında hiçbir ilişki gözlenmedi, hastalık ve kontrol grupları arasında da herhangi bir fark kaydedilme

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	MİSHRA S, KADNUR M, JARTARKAR S, KELOJİ H, AGARWAL R, BABU S (2022). Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. , 28 - 33. 10.4274/turkderm.galenos.2021.69797
Chicago	MİSHRA Swayamsidda,KADNUR Manjunath,JARTARKAR Shishira R.,KELOJİ Hanumanthayya,AGARWAL Ritu,BABU Spoorthy Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. (2022): 28 - 33. 10.4274/turkderm.galenos.2021.69797
MLA	MİSHRA Swayamsidda,KADNUR Manjunath,JARTARKAR Shishira R.,KELOJİ Hanumanthayya,AGARWAL Ritu,BABU Spoorthy Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. , 2022, ss.28 - 33. 10.4274/turkderm.galenos.2021.69797
AMA	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. . 2022; 28 - 33. 10.4274/turkderm.galenos.2021.69797
Vancouver	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. . 2022; 28 - 33. 10.4274/turkderm.galenos.2021.69797
IEEE	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S "Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study." , ss.28 - 33, 2022. 10.4274/turkderm.galenos.2021.69797
ISNAD	MİSHRA, Swayamsidda vd. "Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study". (2022), 28-33. https://doi.org/10.4274/turkderm.galenos.2021.69797

APA	MİSHRA S, KADNUR M, JARTARKAR S, KELOJİ H, AGARWAL R, BABU S (2022). Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. Türkderm Türk deri hastalıkları ve frengi arşivi, 56(1), 28 - 33. 10.4274/turkderm.galenos.2021.69797
Chicago	MİSHRA Swayamsidda,KADNUR Manjunath,JARTARKAR Shishira R.,KELOJİ Hanumanthayya,AGARWAL Ritu,BABU Spoorthy Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. Türkderm Türk deri hastalıkları ve frengi arşivi 56, no.1 (2022): 28 - 33. 10.4274/turkderm.galenos.2021.69797
MLA	MİSHRA Swayamsidda,KADNUR Manjunath,JARTARKAR Shishira R.,KELOJİ Hanumanthayya,AGARWAL Ritu,BABU Spoorthy Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. Türkderm Türk deri hastalıkları ve frengi arşivi, vol.56, no.1, 2022, ss.28 - 33. 10.4274/turkderm.galenos.2021.69797
AMA	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. Türkderm Türk deri hastalıkları ve frengi arşivi. 2022; 56(1): 28 - 33. 10.4274/turkderm.galenos.2021.69797
Vancouver	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study. Türkderm Türk deri hastalıkları ve frengi arşivi. 2022; 56(1): 28 - 33. 10.4274/turkderm.galenos.2021.69797
IEEE	MİSHRA S,KADNUR M,JARTARKAR S,KELOJİ H,AGARWAL R,BABU S "Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study." Türkderm Türk deri hastalıkları ve frengi arşivi, 56, ss.28 - 33, 2022. 10.4274/turkderm.galenos.2021.69797
ISNAD	MİSHRA, Swayamsidda vd. "Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study". Türkderm Türk deri hastalıkları ve frengi arşivi 56/1 (2022), 28-33. https://doi.org/10.4274/turkderm.galenos.2021.69797