Yıl: 2022 Cilt: 9 Sayı: 1 Sayfa Aralığı: 19 - 25 Metin Dili: İngilizce DOI: 10.17350/HJSE19030000251 İndeks Tarihi: 29-07-2022

An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group

Öz:
The tetra substituted Zn(II) phthalocyanine complex having the dicyanophenoxy)-3-methoxybenzoic acid group had been obtained from 4-(3, 4-dicyanophenoxy)-3-methoxybenzoic acid and analyzed with the application of FT-IR, NMR, UV/Vis techniques in compliance withreported literature. The interacting property of Pc4 by CT-DNA was examined with absorption bands, emission titrations, melting temperature, viscosity, and gel electrophoresis procedures. The obtained findings from these techniques demonstrated that the complex containing the dicyanophenoxy)-3-methoxybenzoic acid binds to the DNA by means of intercalation attachment mechanisms.
Anahtar Kelime: Gel electrophoresis CT-DNA Absorption specta Zinc phthalocyanine

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Yılmaz F, Ozer M, Kani I, Bekaroglu O. Catalytic activity of a thermoregulated, phase-separable Pd(II)-perfluoroalkylphthalocyanine complex in an organic/fluorous biphasic system: hydrogenation of olefins. Catalysis Letters 130 (2009) 642-647.
  • 2. Leznoff CC, Lever ABP. Phthalocyanines Properties and Applications. VCH Publisher, New York, Vol. 2, 1993.
  • 3. Leznoff CC, Lever ABP. Phthalocyanines Properties and Applications. VCH Publisher, New York, Vol. 1, 1989.
  • 4. Parra V, Bouvet M, Brunet J, Rodríguez-Mendez ML, Saja JA. On the effect of ammonia and wet atmospheres on the conducting properties of different lutetium bisphthalocyanine thin films. Thin Solid Films 516 (2008) 9012-9019.
  • 5. Bouvet M. Phthalocyanine-based field-effect transistors as gas sensor. Analytical and Bioanalytical Chemistry 384 (2006) 366-373.
  • 6. Rosenthal I. Phthalocyanines as photodynamic sensitizer. Photochemistry and hotobiology 53 (1991) 859-870.
  • 7. Leznoff CC, Lever ABP. Phthalocyanines, Properties and Applications. VCH Publisher, New York, 1996.
  • 8. Hadjiliadis ND, Sletten E. Metal complex–DNA interactions. Wiley-Blackwell, New York, 2009.
  • 9. Van Holst M, M.P. Grant MP, Aldrich-Wright J. Metallointercalators- Synthesis and Techniques to Probe Their Interactions with Biomolecules. Springer Wien, New York, 2011.
  • 10. Lukyanets EA. Phthalocyanines as photosensitizers in the photodynamic therapy of cancer. Journal of Porphyrins and Phthalocyanines 3 (1999) 424–432.
  • 11. Vummidi BR, Noreen F, Alzeer J, Moelling K, Luedtke NW. Photodynamic agents with anti-metastatic activities. ACS Chemical Biology 8 (2013) 1737–1746.
  • 12. Yildiz BT, Sezgin T, Cakar ZP, Uslan C, Sesalan BS. The use of novel photobleachable phthalocyanines to image DNA. Synthetic Metals 161 (2011) 1720–1724.
  • 13. Amitha GS, Vasudevan S. DNA/BSA binding studies of peripherally tetra substituted neutral azophenoxy zinc phthalocyanine. Polyhedron 175 (2020) 114208
  • 14. Ali A, Bhattacharya S. DNA binders in clinical trials and chemotherapy. Bioorganic Medicinal Chemistry 22 (2014) 4506–4521.
  • 15. Alam MDF, Varshney S, Khan MA, Laskar AA, Younus H. In vitro DNA binding studies of therapeutic and prophylactic drug citral. International Journal of Biological Macromolecules 113 (2018) 300–8.
  • 16. Palchaudhuri R, Hergenrother PJ. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Current. Opinion in biotechnology 18 (2007) 497–503.
  • 17. Bağda E, Yabaş E,Bağda E. Analytical approaches for clarification of DNA-double deckerphthalocyanine binding mechanism: As an alternative anticancer chemotherapeutic. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 172 (2017) 199–204
  • 18. Rescifina A, Zagni C, Varrica MG, Pistarà V, Corsaro A. Recent advances in small organic molecules as DNA intercalating agents: synthesis, activity, and modeling. European journal of medicinal chemistry 74 (2014) 95–115.
  • 19. Ozluer C, Satana Kara HE. In vitro DNA binding studies of anticancer drug idarubicin using spectroscopic techniques. Journal of photochemistry and photobiology. B, Biology 138 (2014) 36–42.
  • 20. Williams AK, Dasilva SC, Bhatta A, Rawal B, Liu M, Korobkova EA. Determination of the drug-DNA binding modes using fluorescence-based assays. Analytical Biochemistry 411 (2012) 66–73.
  • 21. Özkay Y, Işıkdağ İ, İncesu Z, Akalın G. Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl)phenyl]acetamide derivatives and evaluation of their anticancer activity. European Journal of Medicinal Chemistry 45 (2010) 3320–3328.
  • 22. Uslan C, Sesalan BŞ. The synthesis, photochemical and biological properties of new silicon phthalocyanines. Inorganica Chimica Acta 394 (2013) 353–362.
  • 23. Özgül G, Taştemel A, Özkaya AR, Bulut M. Synthesis, characterization and comparative electrochemistry of beta and alpha tetra-[4-oxy-3-methoxybenzoic acid]-substituted Zn(II), Co(II) and Cu(II) phthalocyanines. Polyhedron 85 (2015) 181-189.
  • 24. Wolfe A, Shimer GH, Meehan T. Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry 26 (1987) 6392–6396.
  • 25. Liu X-W, Shen Y-M, Li Z-X, Zhong X, Chen Y-D, Zhang S-B. Study on DNA binding behavior and light switch effect of new coumarin-derived Ru(II) complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 149 (2015) 150–156.
  • 26. Barton JK, Goldberg JM, Kumar CV, Turro NJ. Binding modes and base specificity of tris(phenanthroline)ruthenium(II) enantiomers with nucleic acids: tuning the stereoselectivity Journal of American Chemical 108 (1986) 2081–2088.
  • 27. Shoukry AA, Mohamed MS. DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,20 -bipyridine and 1-phenylpiperazine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 96 (2012) 586–593.
APA ARSLANTAS A, AGIRTAS M, Ballı Z (2022). An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. , 19 - 25. 10.17350/HJSE19030000251
Chicago ARSLANTAS Ali,AGIRTAS Mehmet Salih,Ballı Zekeriya An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. (2022): 19 - 25. 10.17350/HJSE19030000251
MLA ARSLANTAS Ali,AGIRTAS Mehmet Salih,Ballı Zekeriya An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. , 2022, ss.19 - 25. 10.17350/HJSE19030000251
AMA ARSLANTAS A,AGIRTAS M,Ballı Z An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. . 2022; 19 - 25. 10.17350/HJSE19030000251
Vancouver ARSLANTAS A,AGIRTAS M,Ballı Z An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. . 2022; 19 - 25. 10.17350/HJSE19030000251
IEEE ARSLANTAS A,AGIRTAS M,Ballı Z "An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group." , ss.19 - 25, 2022. 10.17350/HJSE19030000251
ISNAD ARSLANTAS, Ali vd. "An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group". (2022), 19-25. https://doi.org/10.17350/HJSE19030000251
APA ARSLANTAS A, AGIRTAS M, Ballı Z (2022). An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. Hittite Journal of Science and Engineering, 9(1), 19 - 25. 10.17350/HJSE19030000251
Chicago ARSLANTAS Ali,AGIRTAS Mehmet Salih,Ballı Zekeriya An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. Hittite Journal of Science and Engineering 9, no.1 (2022): 19 - 25. 10.17350/HJSE19030000251
MLA ARSLANTAS Ali,AGIRTAS Mehmet Salih,Ballı Zekeriya An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. Hittite Journal of Science and Engineering, vol.9, no.1, 2022, ss.19 - 25. 10.17350/HJSE19030000251
AMA ARSLANTAS A,AGIRTAS M,Ballı Z An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. Hittite Journal of Science and Engineering. 2022; 9(1): 19 - 25. 10.17350/HJSE19030000251
Vancouver ARSLANTAS A,AGIRTAS M,Ballı Z An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group. Hittite Journal of Science and Engineering. 2022; 9(1): 19 - 25. 10.17350/HJSE19030000251
IEEE ARSLANTAS A,AGIRTAS M,Ballı Z "An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group." Hittite Journal of Science and Engineering, 9, ss.19 - 25, 2022. 10.17350/HJSE19030000251
ISNAD ARSLANTAS, Ali vd. "An Investigating on DNA Binding Activity of Zn(II) Phthalocyanine Complex Having Tetra Substituted Phenoxy-3-methoxybenzoic Acid Group". Hittite Journal of Science and Engineering 9/1 (2022), 19-25. https://doi.org/10.17350/HJSE19030000251