Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center

Özboz, Ezgi Sezen; PEHLİVAN, Yavuz; Yağız, Burcu; Dalkılıç, Ediz; tufan, ayse nur; Coskun, Belkis Nihan; Ermurat, Selime

doi:10.18621/eurj.983279

Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center

Nihan COŞKUN, (Uludağ Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Bursa, Türkiye)

Burcu Yağız, (Afyonkarahisar Devlet Hastanesi, Romatoloji Anabilim Dalı, Afyonkarahisar, Türkiye)

Ezgi Sezen Özboz, (Bornova Türkan Özilhan Devlet Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye)

Ayşe Nur Tufan, (Haseki Eğitim ve Araştırma Hastanesi, Romatoloji Anabilim Dalı, İstanbul, Türkiye)

Selime Ermurat, (Sağlık Bilimleri Üniversitesi, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Romatoloji Anabilim Dalı, Bursa, Türkiye)

Yavuz Pehlivan, (Uludağ Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Bursa, Türkiye)

Ediz DALKILIÇ (Uludağ Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Bursa, Türkiye)

The European Research Journal

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Yıl: 2022 Cilt: 8 Sayı: 2 Sayfa Aralığı: 162 - 168 Metin Dili: İngilizce DOI: 10.18621/eurj.983279 İndeks Tarihi: 29-07-2022

Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center

Öz:

Objectives: To find out the effects and prevalence of disease-modifying antirheumatic drugs (DMARDs) and anti-TNF agents on hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)-positive patients with rheumatic diseases (RD). Methods: This retrospective study was conducted on 1,548 RD patients. Patients’ medical records regarding immunological profiles, clinical courses, and outcomes, were obtained. In this research, the patient used conventional DMARDs (cDMARDs) and biological DMARDs (bDMARDs). A drug exposure was considered when a patient was administered GC, cDMARDs, or bDMARDs for > 4 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin were measured. HBsAg, HBV DNA assay, anti-HCV and HIV were identified. Results: HBsAg was positive in 19 (37.3%) patients. Anti-HBs in 5 (9.8%) patients and anti-HBc IgG in 35 (68.6%) patients were positive. All patients with HBsAg positivity were receiving antiviral prophylaxis. Anti-HCV was positive in 25.5% (n = 13) of individuals . There was not any reactivation among the patients. No HBV reactivation was observed. Conclusions: Screening before treatment and give prophylaxis to patients who have occult hepatitis or hepatitis B, may be an important factor in the absence of reactivation. Hepatitis screening should be performed in all patients prior to biological treatment is initiated.

Anahtar Kelime: Hepatitis reactivation rheumatic disease Disease-modifying antirheumatic drugs biologic treatment. occult Hepatitis.

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Coskun B, Yağız B, Özboz E, tufan a, Ermurat S, PEHLİVAN Y, Dalkılıç E (2022). Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. , 162 - 168. 10.18621/eurj.983279
Chicago	Coskun Belkis Nihan,Yağız Burcu,Özboz Ezgi Sezen,tufan ayse nur,Ermurat Selime,PEHLİVAN Yavuz,Dalkılıç Ediz Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. (2022): 162 - 168. 10.18621/eurj.983279
MLA	Coskun Belkis Nihan,Yağız Burcu,Özboz Ezgi Sezen,tufan ayse nur,Ermurat Selime,PEHLİVAN Yavuz,Dalkılıç Ediz Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. , 2022, ss.162 - 168. 10.18621/eurj.983279
AMA	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. . 2022; 162 - 168. 10.18621/eurj.983279
Vancouver	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. . 2022; 162 - 168. 10.18621/eurj.983279
IEEE	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E "Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center." , ss.162 - 168, 2022. 10.18621/eurj.983279
ISNAD	Coskun, Belkis Nihan vd. "Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center". (2022), 162-168. https://doi.org/10.18621/eurj.983279

APA	Coskun B, Yağız B, Özboz E, tufan a, Ermurat S, PEHLİVAN Y, Dalkılıç E (2022). Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. The European Research Journal, 8(2), 162 - 168. 10.18621/eurj.983279
Chicago	Coskun Belkis Nihan,Yağız Burcu,Özboz Ezgi Sezen,tufan ayse nur,Ermurat Selime,PEHLİVAN Yavuz,Dalkılıç Ediz Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. The European Research Journal 8, no.2 (2022): 162 - 168. 10.18621/eurj.983279
MLA	Coskun Belkis Nihan,Yağız Burcu,Özboz Ezgi Sezen,tufan ayse nur,Ermurat Selime,PEHLİVAN Yavuz,Dalkılıç Ediz Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. The European Research Journal, vol.8, no.2, 2022, ss.162 - 168. 10.18621/eurj.983279
AMA	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. The European Research Journal. 2022; 8(2): 162 - 168. 10.18621/eurj.983279
Vancouver	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center. The European Research Journal. 2022; 8(2): 162 - 168. 10.18621/eurj.983279
IEEE	Coskun B,Yağız B,Özboz E,tufan a,Ermurat S,PEHLİVAN Y,Dalkılıç E "Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center." The European Research Journal, 8, ss.162 - 168, 2022. 10.18621/eurj.983279
ISNAD	Coskun, Belkis Nihan vd. "Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center". The European Research Journal 8/2 (2022), 162-168. https://doi.org/10.18621/eurj.983279