The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity
Yıl: 2021 Cilt: 55 Sayı: 2 Sayfa Aralığı: 70 - 74 Metin Dili: İngilizce DOI: 10.4274/turkderm.galenos.2020.30503 İndeks Tarihi: 03-06-2022
The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity
Öz: Background and Design: In this study, we investigated the role of vitamin D deficiency and autoimmunity in chronic spontaneous urticaria
(CSU) etiopathogenesis and their impact on the disease severity.
Materials and Methods: Sixty patients with CSU aged between 18 and 65 years were enrolled to the study. The control group comprised
40 healthy individuals who had no episodes of urticaria or any other chronic diseases. An autologous serum skin test (ASST) was performed
in all patients. In addition, 25 hydroxyvitamin D, thyroid autoantibodies (TA), anti-nuclear antibody (ANA), and basophils were evaluated in all
groups. Urticaria activity score-7 (UAS7) and dermatological quality of life index (DLQI) of all patients were examined.
Results: Angioedema was more frequent and UAS7 was higher in ASST-positive patients than ASST-negative patients (p=0.035, p=0.018,
respectively). <10 ng/mL vitamin D levels were more fraquently seen in the patients with CU than in the control group (p=0.002). The
frequencies of TA and ANA positivity were higher, and basophil count was lower in all patients compared to the control group (p=0.001,
p=0.001, p=0.001, respectively). The quality of life was more impaired in patients with positive ASST (p=0.011). The duration of the disease
was longer, and UAS7 was higher in patients with positive-TA (p=0.012, p=0.028, respectively). UAS7 was significantly higher in ANA-positive
patients (p=0.042). A significant negative correlation was found between the DLQI and basophil counts (p=0.039).
Conclusion: Understanding the role of vitamin D deficiency, autoimmunity in CSU etiopathogenesis may help treat severe diseases.
Anahtar Kelime: Vitamin D eksikliğinin ve otoimmünitenin kronik spontan ürtikerşiddetine etkisi
Öz: Amaç: Bu çalışmada kronik spontan ürtiker (KSÜ) etiyopatogenezinde D vitamini eksikliği ve otoimmünitenin rolünü ve bunların hastalık
şiddetine etkisini araştırmayı amaçladık.
Gereç ve Yöntem: On sekiz-altmış beş yaşları arasındaki 60 KSÜ hastası çalışmaya dahil edildi. Kontrol grubu daha önce ürtiker atağı
geçirmemiş ve kronik hastalığı olmayan 40 sağlıklı bireyden oluşuyordu. Tüm hastalara otolog serum deri testi (ASST) yapıldı. Tüm gruplarda 25
hidroksivitamin D, tiroid otoantikorları (TA), antinükleer antikor (ANA) ve bazofiller değerlendirildi. Tüm hastaların ürtiker aktivite skoru-7 (UAS7)
ve dermatolojik yaşam kalitesi indeksi (DLQI) incelendi.
Bulgular: ASST pozitif olan hastalarda anjiyoödem, ASST negatif olanlara göre daha sık ve UAS7 daha yüksekti (sırasıyla; p=0,035, p=0,018).
<10 ng/mL D vitamini düzeyleri hastalarda sağlıklı kontrollere göre daha sıktı (p=0,002). Tüm hastalarda kontrol grubuna göre TA ve ANA daha
yüksekti ve bazofil sayısı daha düşüktü (sırasıyla; p=0,001, p=0,001, p=0,001). ASST-pozitif hastalarda yaşam kalitesi daha fazla bozulmuştu
(p=0,011). TA-pozitif olan hastalarda hastalık süresi daha uzundu ve UAS7 daha yüksekti (sırasıyla; p=0,012, p=0,028). ANA-pozitif olan
hastalarda UAS7 anlamlı olarak daha yüksekti (p=0,042). DLQI ve bazofil sayısı arasında anlamlı negatif korelasyon bulundu (p=0,039).
Sonuç: KSÜ etiyopatogenezinde D vitamini eksikliğinin ve otoimmünitenin rolünü anlamak, şiddetli hastalığı tedavi etmemize yardımcı
olmaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Metin N, Erdem M (2021). The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. , 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| Chicago | Metin Nurcan,Erdem Mustafa Teoman The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. (2021): 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| MLA | Metin Nurcan,Erdem Mustafa Teoman The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. , 2021, ss.70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| AMA | Metin N,Erdem M The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. . 2021; 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| Vancouver | Metin N,Erdem M The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. . 2021; 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| IEEE | Metin N,Erdem M "The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity." , ss.70 - 74, 2021. 10.4274/turkderm.galenos.2020.30503 |
| ISNAD | Metin, Nurcan - Erdem, Mustafa Teoman. "The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity". (2021), 70-74. https://doi.org/10.4274/turkderm.galenos.2020.30503 |
| APA | Metin N, Erdem M (2021). The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi, 55(2), 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| Chicago | Metin Nurcan,Erdem Mustafa Teoman The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi 55, no.2 (2021): 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| MLA | Metin Nurcan,Erdem Mustafa Teoman The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi, vol.55, no.2, 2021, ss.70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| AMA | Metin N,Erdem M The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi. 2021; 55(2): 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| Vancouver | Metin N,Erdem M The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi. 2021; 55(2): 70 - 74. 10.4274/turkderm.galenos.2020.30503 |
| IEEE | Metin N,Erdem M "The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity." Türkderm Türk deri hastalıkları ve frengi arşivi, 55, ss.70 - 74, 2021. 10.4274/turkderm.galenos.2020.30503 |
| ISNAD | Metin, Nurcan - Erdem, Mustafa Teoman. "The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity". Türkderm Türk deri hastalıkları ve frengi arşivi 55/2 (2021), 70-74. https://doi.org/10.4274/turkderm.galenos.2020.30503 |
