Yıl: 2022 Cilt: 23 Sayı: 2 Sayfa Aralığı: 85 - 89 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2022.47542 İndeks Tarihi: 17-06-2022

The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease

Öz:
Introduction: Pregnancy is considered a low-grade inflammatory state presented with increased levels of pro-inflammatory markers. Despite the well-recognized association between inflammation and kidney injury, there is still a lack of available data concerning the role of thyroid hormone alterations in inflammation and acute kidney injury (AKI). We examined the relationship of kidney injury molecule-1 (KIM-1) and interleukin-1 beta (IL-1β) with renal and hepatic injury in hypothyroid, normothyroid (euthyroid), or hyperthyroid pregnant women. Methods: A total of 77 pregnant women with no additional health problems were enrolled in the study. Serum KIM-1 and IL-1β levels were analyzed by ELISA. Results: There were significant differences between normothyroid, hyperthyroid, and hypothyroid pregnants regarding creatinine, aspartate aminotransferase (AST), free T4, anti-thyroglobulin (anti-TG), anti-thyroperoxidase (anti-TPO), and plateletcrit (PCT) levels (p=0.018, p=0.032, p=0.011, p=0.001, p=0.003, and p=0.016, respectively). The mean creatinine levels of the hypothyroid group were significantly higher than those of the hyperthyroid group (p=0.015). The mean AST and PCT levels of the hypothyroid group were considerably higher than those of the normothyroid group (p=0.024 and p=0.014, respectively). In the correlation analysis, age was the single parameter that was significantly correlated with KIM-1 and IL-1β in all pregnant women (p=-0.024 and p=-0.018, respectively). In the hypothyroid pregnant women group, KIM-1 was correlated with creatinine levels and age (p=0.037 and p=0.022, respectively). Conclusion: KIM-1 level in pregnant women with hypothyroidism can serve as a useful biomarker to show AKI.
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APA SAGLAM E, Esen B, pilten güzel s, gözütok v, Atay A (2022). The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. , 85 - 89. 10.4274/imj.galenos.2022.47542
Chicago SAGLAM EMEL,Esen Bennur,pilten güzel saadet,gözütok vüsale,Atay Ahmet Engin The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. (2022): 85 - 89. 10.4274/imj.galenos.2022.47542
MLA SAGLAM EMEL,Esen Bennur,pilten güzel saadet,gözütok vüsale,Atay Ahmet Engin The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. , 2022, ss.85 - 89. 10.4274/imj.galenos.2022.47542
AMA SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. . 2022; 85 - 89. 10.4274/imj.galenos.2022.47542
Vancouver SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. . 2022; 85 - 89. 10.4274/imj.galenos.2022.47542
IEEE SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A "The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease." , ss.85 - 89, 2022. 10.4274/imj.galenos.2022.47542
ISNAD SAGLAM, EMEL vd. "The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease". (2022), 85-89. https://doi.org/10.4274/imj.galenos.2022.47542
APA SAGLAM E, Esen B, pilten güzel s, gözütok v, Atay A (2022). The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. İstanbul Medical Journal, 23(2), 85 - 89. 10.4274/imj.galenos.2022.47542
Chicago SAGLAM EMEL,Esen Bennur,pilten güzel saadet,gözütok vüsale,Atay Ahmet Engin The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. İstanbul Medical Journal 23, no.2 (2022): 85 - 89. 10.4274/imj.galenos.2022.47542
MLA SAGLAM EMEL,Esen Bennur,pilten güzel saadet,gözütok vüsale,Atay Ahmet Engin The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. İstanbul Medical Journal, vol.23, no.2, 2022, ss.85 - 89. 10.4274/imj.galenos.2022.47542
AMA SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. İstanbul Medical Journal. 2022; 23(2): 85 - 89. 10.4274/imj.galenos.2022.47542
Vancouver SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease. İstanbul Medical Journal. 2022; 23(2): 85 - 89. 10.4274/imj.galenos.2022.47542
IEEE SAGLAM E,Esen B,pilten güzel s,gözütok v,Atay A "The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease." İstanbul Medical Journal, 23, ss.85 - 89, 2022. 10.4274/imj.galenos.2022.47542
ISNAD SAGLAM, EMEL vd. "The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease". İstanbul Medical Journal 23/2 (2022), 85-89. https://doi.org/10.4274/imj.galenos.2022.47542